Assessing the Liverpool Respiratory Symptom Questionnaire in children with cystic fibrosis

Abstract

Monitoring respiratory status in cystic fibrosis (CF) is challenging, particularly in young children. We aimed to test whether the Liverpool Respiratory Symptom Questionnaire (LRSQ) could distinguish well, pre-school and older children with and without CF, whether it could distinguish well and unwell children with CF and, finally, whether LRSQ scores in older children with CF correlated with established measures of disease severity.20 stable pre-school children with CF had significantly higher total LRSQ scores than 51 preschool controls, and higher scores in two out of eight domains. Similarly, 21 stable 6-to 12-yr-old children with CF had higher total scores than 97 6-to 12-yr-old controls, and higher scores in seven out of eight domains.In older children with CF, LRSQ scores correlated negatively with Shwachman score and forced expiratory volume in 1 s (r5 -0.58, p,0.001, n531; and r5 -0.46, p,0.010, n534, respectively). Within the CF group, patients who cultured Pseudomonas aeruginosa, who used more ''back-up'' antibiotics or whose school attendance was lower also had higher LRSQ scores.The LRSQ differentiates well children from those with CF in both pre-school and the 6-to 12-yrold age group, even at a point of stability. It also differentiates stable from unwell children with CF, and scores correlate with other measures of respiratory disease, highlighting its potential as a clinical monitoring tool in paediatric CF.

Determinants of exercise capacity in school-aged esophageal atresia patients

“…Lastly, we did not perform standardized evaluations of respiratory symptoms, tracheomalacia, and gastroesophageal reflux disease (GERD) at the age of 8 for this cohort. A standardized and validated questionnaire for respiratory symptoms as the Liverpool respiratory symptom questionnaire, may be worthwhile to validate for EA patients in future research.…”

Management of Prematurity-Associated Wheeze and Its Association with Atopy

“…Children aged five years or less were sent the validated Liverpool Respiratory Symptom Questionnaire (LRSQ) [ 16 ] and a modified International Study of Asthma and Allergies in Children (ISAAC) questionnaire was mailed to children aged five years or older [ 9 , 17 ]. The ISAAC questionnaire was modified by including questions relating to respiratory symptoms and the LRSQ was a questionnaire designed to assess respiratory symptoms in young children, having been validated in patients with cystic fibrosis[ 18 ]. All returned questionnaires were scanned, validated, checked for accuracy and stored in a secure database (Remark Office OMR 8, Gravic, Philadelphia, USA).…”

An Observational Study Examining the Relationship between Respiratory Symptoms, Airway Inflammation and Bacteriology in Children with Severe Neurodisability

“…Parents of all participants provided information about their child’s recent respiratory symptoms by completing the Liverpool Respiratory Symptom Questionnaire (LRSQ), previously validated in preschool children with wheeze, and children with cystic fibrosis. [ 5 , 6 ] The questionnaire covers respiratory symptoms over the previous three months and is divided into eight domains; daytime, night-time, interval, activity and other respiratory symptoms, symptoms with colds, the effect of symptoms on the child, and the effect of symptoms on the family. As by definition, the ND study group were not independently mobile, we removed the ‘activity symptoms’ domain and a question regarding physical activity in the ‘effect on the child’ domain for the purposes of this study, thus creating a modified questionnaire (LRSQ-Neuro).…”