Determinants of exercise capacity in school-aged esophageal atresia patients

Toussaint-Duyster, Leontien C C; Zijp, Monique H M van der Cammen-van; Spoel, Marjolein; Lam, Mhanfei; Wijnen, René; Jongste, Johan C. de; Tibboel, Dick; Rosmalen, Joost van; IJsselstijn, Hanneke

doi:10.1002/ppul.23687

Cited by 15 publications

(31 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, most common complaints during exercise were respiratory symptoms and gastroesophageal reflux disease, which occurred mainly during vigorous activity like running or great exertion of strength. Chronic lung disease, GERD and growth retardation have also been described as main chronic morbidities in children with EA by other authors ( 1 , 4 , 19 ). Each of these conditions has a negative impact on athletic performance.…”

Section: Discussionmentioning

confidence: 82%

“…Promotion of physical activity is particularly important for children with pre-existing health conditions. Children with chronic disease generally show a decreased exercise capacity that might be due to physical inactivity caused by prolonged hospitalization, recurrent infection and growth retardation during early childhood ( 4 , 7 ). Esophageal atresia is a complex health-condition that adversely affects the gastrointestinal and respiratory system.…”

Section: Discussionmentioning

confidence: 99%

“…For most children, physical activity and sports participation are important pillars of physical health, social engagement, and emotional well-being ( 2 ). Previous studies have shown significantly reduced spirometric exercise capacity and total lung capacity in children after EA repair ( 3 , 4 ). Furthermore, spirometry revealed airway obstruction in about half of EA patients, correlating well with clinical symptoms ( 5 ).…”

Section: Introductionmentioning

confidence: 87%

See 2 more Smart Citations

Physical Fitness and Locomotor Skills in Children With Esophageal Atresia-A Case Control Pilot Study

König

Muensterer

2018

Front. Pediatr.

View full text Add to dashboard Cite

Background: Patients with esophageal atresia (EA) often experience physical limitations. With increasing survival over the past decades, the focus in care shifted toward improving the long-term quality of life. We performed validated testing fitness and motor skills in children born with EA.Methods: Patients with EA were evaluated using the standardized Kinderturntest Plus/ Deutscher Motorik Test after caregiver's written consent. Test scores range from 1 to 5 (compared to an age- and gender matched standard population). Caregivers completed an online-questionnaire on patient history.Results: Seventeen patients (median age 7 [3–12] years) were included. Comorbidities were prematurity (54%), birth weight <1,500 g (23%), congenital heart disease (46%), developmental delay (38%), skeletal deformity (23%), and anorectal malformation (15%). The mean test score was significantly lower in children with EA (2.19) compared to a control group matched for age, gender, body weight, and –height, (2.75, p = 0.04), and the general population (3, p = 0.00). Distribution of patient scores was below the 41st performance percentile for gender and age in 54–63%. Caregivers identified notable deficits of strength and endurance. All but one patient complained about discomfort during physical exercise, most commonly respiratory distress (46%) and gastroesophageal reflux symptoms (31%). Notably, 93% of subjects participated in regular school physical education classes, and 86% participated regularly in additional organized sporting activities.Conclusions: Children after EA repair have decreased physical fitness and impaired locomotor function compared to the general population on a standardized test. Physical discomfort is frequent during exertion. To avoid demotivation, locomotor skill should be promoted at each individual's comfortable level.The study was registered at www.researchregistry.com (No. 3707).

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Physical Fitness and Locomotor Skills in Children With Esophageal Atresia-A Case Control Pilot Study

König

Muensterer

2018

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…Impulse oscillometry (IOS) is easier for young children to perform than spirometry, and the difference between patients with esophageal atresia. 44 Exercise capacity was significantly diminished and all spirometric parameters were reduced in patients with esophageal atresia. Decreased exercise capacity did not correlate with spirometric indices, and the authors speculate that diminished physical activity due to chronic disease state and physical growth failure are responsible for exercise limitation in these patients.…”

Section: Usemann Et Al Measured Interrupter Resistance (Rint) In Unsementioning

confidence: 94%

“…This supports early resection of CPAM and normal exercise habits in these children. Toussaint‐Duyster et al performed exercise testing and spirometry at 8 years of age in 63 patients with esophageal atresia . Exercise capacity was significantly diminished and all spirometric parameters were reduced in patients with esophageal atresia.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Pulmonology year in review 2017: Part 3

Ren

Muston

Yılmaz

et al. 2018

Pediatric Pulmonology

View full text Add to dashboard Cite

Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

show abstract

Pulmonary function in children and adolescents after esophageal atresia repair

Donoso

Hedenström

Malinovschi

et al. 2019

Pediatric Pulmonology

View full text Add to dashboard Cite

IntroductionRespiratory morbidity after esophageal atresia (EA) is common. The aims of this study were to assess pulmonary function, to identify risk factors for pulmonary function impairment (PFI), and to investigate the relations between respiratory morbidity, defined as medical treatment for respiratory symptoms or recent pneumonia and PFI after EA repair.Material and MethodsSingle center retrospective observational study including patients with EA who participated in the follow‐up program for 8‐ or 15‐year old patients from 2014 to 2018 and performed pulmonary function testing by body plethysmography, dynamic spirometry, impulse oscillometry, and diffusing capacity of the lungs. Univariate and multiple stepwise logistic regression with PFI as outcome were performed. Anastomotic leak, episodes of general anesthesia, extubation day, birth weight, age at follow up, gross classification, and abnormal reflux index were independent variables.ResultsIn total, 47 patients were included. PFI was found in 19 patients (41%) and 16 out of 19 patients (84%) had an obstructive pattern. Respiratory morbidity was found in 23 (52%, NA = 3) of the patients with no correlation to PFI. Birth weight, age at follow‐up, and episodes of general anesthesia were identified as risk factors for PFI.ConclusionRespiratory morbidity and PFI were common in children and adolescents after EA repair. The major component of PFI was obstruction of the airways. The risk for PFI increased with lower birth weight and older age at follow up. The poor correlation between respiratory morbidity and PFI motivates the need of clinical follow up including pulmonary function tests.

show abstract

Determinants of exercise capacity in school-aged esophageal atresia patients

Cited by 15 publications

References 38 publications

Physical Fitness and Locomotor Skills in Children With Esophageal Atresia-A Case Control Pilot Study

Physical Fitness and Locomotor Skills in Children With Esophageal Atresia-A Case Control Pilot Study

Pediatric Pulmonology year in review 2017: Part 3

Pulmonary function in children and adolescents after esophageal atresia repair

Contact Info

Product

Resources

About