Assessing the interest to participate in a dengue vaccine efficacy trial among residents of Puerto Rico

Guerra, Carmen L. Pérez; Rodríguez-Acosta, Rosa L.; Soto-Gomez, Eunice; Zielinski-Gutiérrez, Emily; Peña-Orellana, Marisol; Santiago, Luis M.; Rivera, Reinaldo; Cruz, Ribeiro; Ramirez, Viani; Tomashek, Kay M.; Dayan, Gustavo H.

doi:10.4161/hv.20056

Cited by 8 publications

(4 citation statements)

References 44 publications

(71 reference statements)

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“…In the present study, confidence in vaccine safety was most strongly associated with willingness to participate, followed by trust in science. This is consistent with previous research findings that also identified correlations between the willingness to participate in a vaccine trial and trust (Detoc et al, 2017;Jaffe et al, 2020;Pérez Guerra et al, 2012). Surprisingly, information about questionable research practices was positively related with the willingness to participate.…”

Section: Discussionsupporting

confidence: 92%

Debunking Misinformation and Communicating Critical Events in Vaccine Trials

Eitze

Shamsrizi

Addo

et al. 2022

EJHC

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Misinformation and media reports about critical events in vaccine trials challenge public confidence in Covid-19 vaccine safety. Three online experiments using 2×2 between-subjects designs examined the impact of vaccine type, misinformation debunking, and critical events during vaccine trials. In Experiment 1, N = 984 participants received information about different vaccines and misinformation was debunked. In Experiment 2, N = 1,018 participants were informed about different vaccines and trial discontinuation. In Experiment 3, N = 1,006 participants received information about discontinuation and questionable research practices of a manufacturer. The main dependent variables were confidence in vaccine safety, vaccination intention, and willingness to participate in a vaccine trial. Debunking increased vaccination intention and confidence (both η2p = .01) which was partly higher for classical than for new vaccines (η2p = .01). Information about discontinuation had no effect, but having heard about it before had benefits. Information about questionable research practices decreased confidence ( η2p = .01) and vaccination intention ( η2p = .02) regarding the target vaccine but did not affect other vaccines. Confidence (β = .47) was most strongly associated with willingness to participate in vaccine trials. Critical events in vaccine trials should be communicated transparently to increase confidence, trial participation, and vaccination intentions.

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Section: Discussionsupporting

confidence: 92%

Debunking Misinformation and Communicating Critical Events in Vaccine Trials

Eitze

Shamsrizi

Addo

et al. 2022

EJHC

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“…This is the first study conducted to specifically explore WTP in dengue research in Indonesia and its related factors. The first study regarding WTP in dengue-related research anywhere was reported from Puerto Rico where WTP in a dengue vaccine efficacy trial had been assessed [ 28 ]. Basically, the concept of our study is similar to those on willingness to donate a blood sample for genetic research.…”

Section: Discussionmentioning

confidence: 99%

“…Up to now, WTP has only very rarely been assessed for research on dengue. The only record we found, from Puerto Rico, assessed the interest to participate in a dengue vaccine efficacy trial [ 28 ] and revealed that barriers for participating in a vaccine trial included lack of information on dengue vaccine candidates, lack of trust in new vaccines and trial procedures, and fear of infection or other side effects.…”

Section: Introductionmentioning

confidence: 99%

Community Willingness to Participate in a Dengue Study in Aceh Province, Indonesia

et al. 2016

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BackgroundDengue virus infection is the most rapidly spreading vector-borne disease in the world. Essential research on dengue virus transmission and its prevention requires community participation. Therefore, it is crucial to understand the factors that are associated with the willingness of communities in high prevalence areas to participate in dengue research. The aim of this study was to explore factors associated with the willingness of healthy community members in Aceh province, Indonesia, to participate in dengue research that would require phlebotomy.Methodology/Principal FindingsA community-based cross-sectional study was carried out in nine regencies and municipalities of Aceh from November 2014 to March 2015. Interviews using a set of validated questionnaires were conducted to collect data on demography, history of dengue infection, socioeconomic status, and knowledge, attitude and practice regarding dengue fever. Two-step logistic regression and Spearman’s rank correlation (rs) analysis were used to assess the influence of independent variables on dependent variables. Among 535 participants, less than 20% had a good willingness to participate in the dengue study. The factors associated with good willingness to participate were being female, working as a civil servant, private employee or entrepreneur, having a high socioeconomic status and good knowledge, attitude and practice regarding dengue. Good knowledge and attitude regarding dengue were positive independent predictors of willingness to participate (OR: 2.30 [95% CI: 1.36–3.90] and 3.73 [95% CI: 2.24–6.21], respectively).Conclusion/SignificanceThe willingness to participate in dengue research is very low among community members in Aceh, and the two most important associated factors are knowledge and attitude regarding dengue. To increase participation rate, efforts to improve the knowledge and attitude of community members regarding dengue fever and dengue-related research is required before such studies are launched.

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“…Previous work, in other countries, on the acceptability of a (hypothetical) DENV vaccine has shown widely differing results -for example, with very high acceptance (94%) of a potential paediatric DENV vaccination programme in an Indonesian survey (Hadisoemarto and Castro, 2013) but poor attitudes to vaccination in another Indonesian study, particularly among those of lower socioeconomic status and with poor knowledge of DENV (Harapan et al, 2016). Major barriers to participation in a DENV vaccine trial (lack of trust and information, fear of side effects and of exploitation) were also identified in Puerto Rico (Guerra et al, 2012). When we asked the participants of Familias sin Dengue about the acceptance of Dengvaxia®, 90% of the answers were, "Yes, I'll accept this vaccine."…”

Section: Dengue Vaccine In An Inter-epidemic Contextmentioning

confidence: 99%

Locating Zika

Bardosh¹

2019

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The emergence of Zika virus in 2015 challenged conventional ideas of mosquitoborne diseases, tested the resilience of health systems and embedded itself within local sociocultural worlds, with major implications for environmental, sexual, reproductive and paediatric health. This book explores this complex viral epidemic and situates it within its broader social, epidemiological and historical context in Latin America and the Caribbean. The chapters include a diverse set of case studies from scholars and health practitioners working across the region, from Brazil, Venezuela, Ecuador, Mexico, Colombia, the United States and Haiti. The book explores how mosquito-borne disease epidemics (not only Zika but also Chikungunya, Dengue and malaria) intersect with social change and health governance. By doing so, the authors reflect on the ways in which situated knowledge and social science approaches can contribute to more effective health policy and practice for mosquito-borne disease threats in a changing world.

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Assessing the interest to participate in a dengue vaccine efficacy trial among residents of Puerto Rico

Cited by 8 publications

References 44 publications

Debunking Misinformation and Communicating Critical Events in Vaccine Trials

Debunking Misinformation and Communicating Critical Events in Vaccine Trials

Community Willingness to Participate in a Dengue Study in Aceh Province, Indonesia

Locating Zika

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