Assessing the interaction between surfactant-like peptides and lipid membranes

Abstract

Positively charged AnK peptides have a higher preference for interacting with the DPPG membrane than remaining hydrated in bulk water.

Surfactants: physicochemical interactions with biological macromolecules

“…When it comes to the study of biosurfactants and membrane lipids interactions, few studies have been reported on molecular interactions (Ortiz et al 2009 ; Aranda et al 2007 ; Rodrigues et al 2006 ; Malaspina et al 2017 ). The effect of trehalose lipids on membrane phospholipids was reported by Ortiz et al ( 2008 ) showing that the biosurfactants exhibit a dehydrating effect on the interfacial region of saturated phosphatidylethanolamines promoting the formation of unsaturated phosphatidylethanolamines.…”

“…Iturin was shown to pass through the cell wall and disrupt the plasma membrane with the formation of small vesicles and the aggregation of intramembranous particles, interacting with the nuclear membrane and probably with membranes of other cytoplasmic organelles affecting the morphology and membrane structure of yeast cells (Thimon et al 1995 ). Recently, the studies in molecular surfactant-like peptides and lipids has become more focused and significant due to their excellent properties, such as versatility, biocompatibility and medicinal properties (Cui et al 2010 ; Hosseinkhani et al 2013 ; Dehsorkhi et al 2014 ; Du and Stenzel 2014 ; Malaspina et al 2017 ; Doostmohammadi et al 2019 ).…”

“…An important class of amphiphilic peptides called surfactant-like peptides (SLPs), present an intrinsic difference that can lead to different physical consequences namely composition and tail structure (Malaspina et al 2017 ). Unlike conventional surfactants whose hydrophobic tails interact in all directions through hydrophobic interactions, the amphiphilic peptide tail contains not only hydrophobic groups but also hydrophilic sites (Colherinhas and Fileti 2014 ).…”

“…These hydrogen bonds associated with hydrophobic interactions can stabilize at a high level, complex secondary structures such as helices and sheets. On the other hand, conventional lipids/surfactants with antimicrobials properties (Chen et al 2010 , 2012 ; Albada et al 2012 ; Gaspar et al 2013 ) are usually organized into micelles, vesicles, and nanotubes (Colherinhas and Fileti 2014 ; Malaspina et al 2017 ). To understand the interaction between (bio)surfactants and lipids, it is necessary to be aware of the hydrodynamics of the molecules involved, their amphiphilic properties and how they play an important role when it comes to biological membranes.…”

Computational Study of the Interaction of a PEGylated Hyperbranched Polymer/Doxorubicin Complex with a Bilipid Membrane

“…Among other model phospholipid layers, dipalmitoylphosphatidylglycerol (DPPG)-based systems have been recently studied in drug/liposome formulations [13]. DPPG membranes (formed by a double layer of lipids, i.e., a bilipid layer) carry a negative charge per lipid at physiological pH conditions [14,15] which renders them good candidates when complexation with cationic bioactive compounds is desired [13,14,16]. This attribute of DPPG lipids can be exploited in more complex drug/liposome formulations, where optimization of the drug loading conditions is promoted by the presence of multifunctional molecules such as hyperbranched polymers [4,17,18].…”