Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices

Abstract

Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character. Hydrophobic and cationic dyes presented high encapsulation efficiency, probably related to electrostatic and hydrophobic interactions with SF. The addition of SF microparticles in SF hydrogels was an effective method to prolong the release, increasing the release time by 10-fold.

Self-assembled silk fibroin hydrogels: from preparation to biomedical applications

“…Tomoda et al produced a controlled-release device composed of SF microparticles embedded in SF hydrogel. 90 First, they produced SF microparticles by an atomization method. Then dye molecules were incorporated into the microparticles by adsorption.…”

Synthesis, characterizations and kinetics of MOF‐5 as herbicide vehicle and its controlled release in PVA/ST biodegradable composite membranes

“…[1] The potential runoff and leaching of herbicide through the soil would still cause severe inefficiency. [1][2][3] Therefore, the controlled release technology has been devoted to achieving controlled release of herbicides. XueQi Zeng and co-workers to attain biodegradable agricultural mulch film with botanical herbicides simultaneously, designed a dual herbicide delivery system to reduce the runoff and leaching of herbicide.…”

“…[1,2] Nevertheless, all traditional materials cannot decompose in soil, which leads to the increase of deleterious wastes in the soil and the environment. [3] As a result, the advancement of biodegradable films has received attention in the agricultural field. [4][5][6] Poly (vinyl alcohol) (PVA) is a biodegradable polymer, which exhibits excellent properties with good film-forming capability, resistance to oxygen permeation, good mechanical properties and transparency in a visible light range feature.…”

“…Agricultural mulches, such as low density polyethylene (LDPE) and polypropylene (PP), have been tested [1,2] . Nevertheless, all traditional materials cannot decompose in soil, which leads to the increase of deleterious wastes in the soil and the environment [3] . As a result, the advancement of biodegradable films has received attention in the agricultural field [4–6] .…”

“…Herbicides containing agrochemicals such as MCPA, atrazine (AT), and 3, 4 D are commonly used in agriculture [1] . The potential runoff and leaching of herbicide through the soil would still cause severe inefficiency [1–3] . Therefore, the controlled release technology has been devoted to achieving controlled release of herbicides.…”