Assessing the impact of air pollution on childhood asthma morbidity: how, when, and what to do

Burbank, Allison J.; Peden, David B.

doi:10.1097/aci.0000000000000422

Cited by 50 publications

(29 citation statements)

References 53 publications

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“…Considerable individual variations in the spirometric response to inhaled SO 2 have been noticed, suggesting a potential genetic link. Children with a particular polymorphism in the TNF-α gene had more significant reductions in lung function after SO 2 exposure [ 74 , 75 ].…”

Section: Outdoor Air Pollutionmentioning

confidence: 99%

Impact of Air Pollution on Asthma Outcomes

Tiotiu

Novakova

Nedeva

et al. 2020

IJERPH

271

151

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Asthma is a chronic respiratory disease characterized by variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Evidence suggests that air pollution has a negative impact on asthma outcomes in both adult and pediatric populations. The aim of this review is to summarize the current knowledge on the effect of various outdoor and indoor pollutants on asthma outcomes, their burden on its management, as well as to highlight the measures that could result in improved asthma outcomes. Traffic-related air pollution, nitrogen dioxide and second-hand smoking (SHS) exposures represent significant risk factors for asthma development in children. Nevertheless, a causal relation between air pollution and development of adult asthma is not clearly established. Exposure to outdoor pollutants can induce asthma symptoms, exacerbations and decreases in lung function. Active tobacco smoking is associated with poorer asthma control, while exposure to SHS increases the risk of asthma exacerbations, respiratory symptoms and healthcare utilization. Other indoor pollutants such as heating sources and molds can also negatively impact the course of asthma. Global measures, that aim to reduce exposure to air pollutants, are highly needed in order to improve the outcomes and management of adult and pediatric asthma in addition to the existing guidelines.

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Section: Outdoor Air Pollutionmentioning

confidence: 99%

Impact of Air Pollution on Asthma Outcomes

Tiotiu

Novakova

Nedeva

et al. 2020

IJERPH

271

151

View full text Add to dashboard Cite

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“…Pollutants, including outdoor ambient pollutants such as ambient air O 3 , NOx (oxides of nitrogen), particulate matter (PM) that is either 0.5 to 2.5 mm (PM2.5) or 2.5 to 10 mm (PM10), as well as indoor PM2.5 (usually encountered in much higher concentrations than ambient outdoor pollutants) resulting from tobacco smoking and use of biomass fuels clearly impact exacerbation and likely development of allergic diseases. [1][2][3] As outlined in the following sections, bacterial and viral exposures induce host responses that influence risk for development of atopic disease. Such exposures include overt infections as well as colonization with microbes, resulting in microbial populations being residentially present on skin and various mucosal sites that modulate immune response (the microbiome).…”

Section: Introductionmentioning

confidence: 99%

The “envirome” and what the practitioner needs to know about it

Peden

2019

Annals of Allergy, Asthma & Immunology

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Ambient air pollutant exposure has been associated with development of both asthma and eczema. Mechanistic plausibility for the effect of pollutants on atopy has been shown in sensitization studies with diesel exhaust particles and in epigenetic studies of circulating T cells from children with increased exposure to ambient pollutants. 2. Environmental public policy that reduces pollution has clearly been shown to decrease community risk for asthma and to improve lung function 3. Microbiome studies have shown that colonization with specific microbes is associated with increased asthma risk. Colonizations with Staphylococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae are all associated with increased risk for asthma events. Colonization with other organisms may be protective. 4. Endotoxin exposure in early life is often associated with decreased atopic sensitization, although endotoxin exposure may worsen nonatopic asthma and may augment response to allergens in sensitized individuals. 5. Maternal and perinatal stress, household and neighborhood violence, and poor housing stock all promote development of allergic disease and asthma.

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“…Children asthma was found to be affected most by NOx than the other pollutants that were studied. NO2 levels in the ambient air have been shown to be associated with emergency department visits for pediatric asthma (Burbank and Peden, 2018;Strickland et al, 2010). Studies found a statistically significantly increased risk of asthma diagnosis with increased early life exposure to NO and NO2 (Clark et al, 2010;Khreis et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Industrial Emissions and Asthma Prevalence

Sims

Leggett

Myla

2020

EUROPEAN J ENV PUBLI

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The pathogenesis of asthma is multifactorial and not completely understood; however, it is considered a chronic inflammatory disease that affects the airways and has a clinical development of wheezing, shortness of breath, chest tightness, and cough. The prevalence of asthma has increased drastically during the past few decades. Urban air pollution from industrial emissions has been implicated as one of the major factors responsible for this increase. The objective of this paper was to analyze the impact of sulfur dioxide (SO2), nitrogen oxides (NOx), and carbon dioxide (CO2) on the overall prevalence of asthma for adults and children. The statistical analysis was conducted using SAS statistical software to determine multiple comparison tests for asthma prevalence among years, ages, ethnicities, and gender, and emissions of SO2, NOx, and CO2 among regions and years. Moreover, SAS was utilized to estimate fully parametric regression models for emission density on total asthma prevalence, child asthma, and adult asthma. In our investigation of asthma prevalence, blacks, females, and children were found to have the highest incidence of asthma. Industrial emissions of SO2, NOx, and CO2 were analyzed, and CO2 had the largest emissions, followed by SO2, and lastly NOx. NOx had the highest correlation with asthma prevalence in child and adult asthma; however, when the influence of SO2, NOx, and CO2 on the overall asthma rate was investigated, CO2 showed the highest correlation. Furthermore, children exposed to SO2, NOx, and CO2 were found to have an increased risk of asthma when compared to adults. This adds to evidence that outdoor air pollution is associated with asthma and that more needs to be done to decrease industrial air pollution.

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Assessing the impact of air pollution on childhood asthma morbidity: how, when, and what to do

Abstract: The link between air pollution and pediatric asthma morbidity is supported by the recent relevant literature. Continued efforts are needed to identify the most vulnerable populations and develop strategies to reduce exposures and improve air quality.

Cited by 50 publications

References 53 publications

Impact of Air Pollution on Asthma Outcomes

Impact of Air Pollution on Asthma Outcomes

The “envirome” and what the practitioner needs to know about it

Industrial Emissions and Asthma Prevalence

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