Nature gas hydrate is a new kind of clean and potential resources. Depressurization is regarded as the most effective and promising hydrate production technology. One of the key points in improving the gas production effectiveness of depressurization is whether pressure gradient could transmit in strata effectively. Single well method is widely used in hydrate exploit which is circumscribed in expanding the range of hydrate decomposition. Consequently, the well structure and production strategy needs to be optimized for improving the gas recovery efficiency. The multilateral well technology is proposed for increasing the gas productivity of the reservoir greatly by increasing the multilateral branches. In this paper, we established a numerical simulation model based on the geological data NGHP-02-16 site in the KG basin to evaluate the gas production performance of the reservoir by depressurization. It mainly focuses on investigating the gas production performance of multilateral wells with different combinations of geometric parameters of multilateral branches, such as different dip angle, numbers, and spacing of lateral branches. The result shows that the multilateral well method can effectively increase the gas production rate with the water production rate increase slightly. The cumulative gas production volume of a single vertical well is about
2.85
×
10
6
m
3
, while it is of the multilateral well can reach
4.18
×
10
6
m
3
during a one-year production. The well interference, the effective influence radius of each multilateral branch, and the vertical depth of the lateral branch are the main factors which affect the gas production efficiency of the multilateral well. The optimization of the geometric parameters of lateral should consider not only the gas production efficiency but also the well interference between the lateral branches.