Assessing the Feasibility of Using an Adverse Drug Reaction Preventability Scale in Clinical Practice

Olivier, Pascale; Boulbés, Olivier; Tubery, M.; Lauque, D.; Montastruc, Jean‐Louis; Lapeyre‐Mestre, Maryse

doi:10.2165/00002018-200225140-00005

Cited by 65 publications

(30 citation statements)

References 15 publications

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“…It is possible that older people who suffer from more serious illness are more frequently hospitalized or referred to tertiary care units. Our finding that ADE-related ED visits more frequently affected the skin (34.21% of total events) and the gastrointestinal system (21.05%) is in agreement with a previous report [21]. The drugs involved were antibiotics, NSAIDs, and agents acting on the renin-angiotensin system.…”

Section: Discussionsupporting

confidence: 93%

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Regional surveillance of emergency-department visits for outpatient adverse drug events

Capuano

Irpino²,

Gallo

et al. 2009

Eur J Clin Pharmacol

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Aims To determine the (1) incidence of adverse drug events (ADEs) in 10 emergency department (EDs) of general hospitals in the Regione Campania (southern Italy), (2) rate of ADE-related hospital admissions, (3) drug classes most frequently involved, and (4) the types of ADEs and their frequency. Methods We performed a cohort study of all patients attending the EDs. This study was carried out in two observational periods of 10 days each in 10 EDs. Demographic, clinical, and pharmacological data about all patients admitted to EDs were collected by trained and qualified monitors. Records related to ADEs were analyzed and validated by a specific scientific committee. Results Of 7,861 ED visits, 96 were ADE-related. The incidence of hospitalization was higher in patients who had taken medication than in patients with a negative drug history (24.9 vs. 16.4%). ADEs were significantly more frequent in women. Patients aged between 60 and 69 years and between 30 and 39 years were significantly more likely to experience an ADE. Serious ADEs were identified in 20 ED visits (20.8% of total sample). Antibiotics, NSAIDs, and agents acting on the renin-angiotensin system were the drugs most often involved in ADEs. In multivariate analyses, the adjusted odds ratio was 3.4 (95% CI: 1.07-2.84) for patients taking NSAIDs, 4.78 (95% CI: 2.26-10.12) for those taking β 2 -adrenergic-receptor agonists, and 6.20 (95%CI: 2.74-14.06) for those taking β-lactam antibiotics. Conclusion This study shows that ADEs are an important problem in industrialized countries. Moreover, it shows that ADEs affect hospital admission rates and reinforces the importance of drug-induced disease as a public health problem.

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Section: Discussionsupporting

confidence: 93%

“…Moreover, recent findings have reported that one-third are likely preventable [21] and that about half could be avoided with greater prescription care [22].…”

Section: Introductionmentioning

confidence: 99%

Regional surveillance of emergency-department visits for outpatient adverse drug events

Capuano

Irpino²,

Gallo

et al. 2009

Eur J Clin Pharmacol

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show abstract

“…Four (3%) articles mentioned assessing the validity of the preventability assessment (56,(61)(62)(63). In one (1%) article (62), an assessment method introduced by the authors was compared with a previously introduced method and the number of identified cases by the two methods was reported.…”

Section: Resultsmentioning

confidence: 99%

“…In one (1%) article (62), an assessment method introduced by the authors was compared with a previously introduced method and the number of identified cases by the two methods was reported. However, no sensitivity or specificity analysis or negative or positive predictive values were not reported.…”

Section: Resultsmentioning

confidence: 99%

Methods for Assessing the Preventability of Adverse Drug Events

et al. 2012

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“…Esto, teniendo presente reacciones adversas a medicamento confirmadas y validadas, significa que por cada RAM confirmada hay muchos más eventos adversos a medicamentos, hecho confirmado también por otros investigadores (30,31). Las RAM pueden causar incrementos significativos de la morbimortalidad de los pacientes, en especial aquellos hospitalizados.…”

Section: Discussionunclassified

Las reacciones adversas a medicamentos: una aproximación desde el punto de vista económico.

Segura

Maldonado

2003

biomedica

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La farmacovigilancia, en cuanto disciplina y actividad de las ciencias de salud dedicada a la recolección de información, análisis y ayuda a la toma de decisiones sobre reacciones adversas a medicamentos (RAM), ha tenido expansión conceptual y práctica desde la década de 1960. No obstante, muy pocos estudios han analizado en profundidad cuánto puede costarle este problema a un sistema de salud. El presente artículo pretende ofrecer un análisis de la literatura disponible, orientado hacia el costo generado por la atención de eventos adversos frente a medicamentos en la práctica médica -basado en datos de la literatura internacional -y ofrece un ejercicio hipotético de extrapolación sobre futuros costos de las RAM en Colombia. La finalidad última del presente artículo es sensibilizar y llamar a la reflexión a los diferentes actores del sector salud sobre el impacto económico y la necesidad de apoyar la implementación y desarrollo de un sistema nacional de farmacovigilancia.Palabras clave: farmacovigilancia, reacción adversa a medicamento, farmacoeconomía. Evaluation of medication side-effects from an economic perspectivePharmacovigilance is a health sciences discipline devoted to the data collection, data analysis and decision-making related to adverse drug reactions (ADR). It has played an expanded theoretical and practical role since the 1960's. However, few studies have made a careful analysis of the decision-making costs in evaluating ADRs. Herein, the relevant literature is reviewed concerning the costs generated due to the attention of the drug adverse events in medical practice. Examples are taken from international literature which offer by extrapolation of the potential future costs of ADR in Colombia. The objective is to sensitize and generate insights about the need for implementation and development of a national pharmacovigilance system.

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Assessing the Feasibility of Using an Adverse Drug Reaction Preventability Scale in Clinical Practice

Cited by 65 publications

References 15 publications

Regional surveillance of emergency-department visits for outpatient adverse drug events

Regional surveillance of emergency-department visits for outpatient adverse drug events

Methods for Assessing the Preventability of Adverse Drug Events

Las reacciones adversas a medicamentos: una aproximación desde el punto de vista económico.

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