Assessing the change of anisometropia in unilateral myopic children receiving monocular orthokeratology treatment

Tsai, Wei-Shan; Wang, Jen-Hung; Lee, Yuan‐Chieh; Chiu, Cheng-Jen

doi:10.1016/j.jfma.2019.02.001

Cited by 20 publications

(26 citation statements)

References 28 publications

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“…However, few studies have focused on the use of Ortho-K for anisomyopia regulation 16 , 18 . In our previous study, the magnitude of unilateral myopic anisometropia was reduced by monocular Ortho-K treatment, in which the inter-eye AL difference plummeted from 0.83 ± 0.45 mm at baseline to 0.59 ± 0.49 mm at 24 months ( P = 0.039) 19 , thereby demonstrating that monocular Ortho-K lenses had effectively suppressed AL elongation of the myopic eyes in unilateral anisomyopic children.…”

Section: Introductionmentioning

confidence: 71%

“…Recent studies have focused particularly more on this specific anisomyopic children by comparing the experimental eye with the patient’s fellow eye as a naturally matched group 18 . Both Ortho-K and topical atropine have been reported to have positive effects on the control of anisomyopia 18 , 19 , 24 . Therefore, the aim of the present study was to further compare the treatment effect of Ortho-K to that of different atropine concentrations in anisomyopic children.…”

Section: Discussionmentioning

confidence: 99%

“…We had obtained written informed consent from all the patients including their parents if the children were under 18 years old before the recruitment. The inclusion and exclusion criteria were adapted from our previous publication 19 .…”

Section: Methodsmentioning

confidence: 99%

“…Appropriate tightness was achieved by observing a thin annular layer of tears, trapped in the reverse curve, forming a bull’s eye configuration. All the fitting profile could be referred to our study published previously 11 , 19 . Children were required to wear the Ortho-K lenses every night for at least 8 consecutive hours.…”

Section: Methodsmentioning

confidence: 99%

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A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children

Tsai

Wang

Chiu

2020

Sci Rep

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Myopic anisometropia (anisomyopia) is a specific type of refractive error that may cause fusion impairment, asthenopia, and aniseikonia. It is sometimes severe enough to reduce the quality of life. Several studies have investigated the treatment effects of orthokeratology (Ortho-K) and topical atropine on anisomyopia control. However, no study has compared these two interventions simultaneously until now. The cohort of this retrospective study included 124 children with anisomyopia who were treated with binocular Ortho-K lenses, 0.01% atropine, or 0.05% atropine. After a 2-year follow-up, the inter-eye difference in axial length (AL) significantly decreased in the Ortho-K group ( P = 0.015) and remained stable in the two atropine groups. When comparing the myopia control effect, the use of Ortho-K lenses resulted in an obviously smaller change in AL than the use of 0.01% and 0.05% atropine ( P < 0.01). Ortho-K treatment may reduce the degree of anisomyopia and stabilise the progression of myopia. Hence, Ortho-K might be a better choice for anisomyopic children.

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Section: Introductionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children

Tsai

Wang

Chiu

2020

Sci Rep

Self Cite

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“…Anisometropia can be classified according to the SEQ in both eyes into simple/compound hyperopic or myopic and mixed anisometropia 5 , 6 . A variety of treatments for anisometropia have been reported, but there is no consensus on the best treatment 5 , 7 . Because most cases of anisometropia result from a difference in axial length (AL) 5 , measuring this length may be useful for the direct monitoring of axial anisometropia, a method that is similar to the myopia control strategy 8 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of axial length to identify the effects of monocular 0.125% atropine treatment for pediatric anisometropia

Kao

Chuang

Lai

et al. 2021

Sci Rep

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The aim of the study is to determine the effects of monocular 0.125% atropine daily treatment on the longer axial length (AL) eyes in children with pediatric anisometropia. This was a retrospective cohort study. The charts of children with anisometropia (aged 6–15 years) who had a > 0.2-mm difference in AL between the two eyes were reviewed. Children who received monocular treatment of 0.125% atropine in the eye with longer AL were included for final analysis. The main outcome measure was the difference in AL between the two eyes after treatment. Regression analysis was used to model the changes in AL according to the time of treatment in both eyes. Finally, forty eyes in 20 patients (mean age 10.2 years) were included in the analyses. During the treatment period, AL was controlled in the treated eyes (p = 0.389) but elongated significantly in the untreated eyes (p < 0.001). The difference in AL between the treated and untreated eyes decreased from 0.57 to 0.22 mm (p < 0.001) after the 1-year treatment period. In the regression model, the best fit for the relationship between changes in AL and time during the treatment period in the treated eyes was the quadratic regression model with a concave function. In conclusion, these data suggest that 0.125% atropine daily is an effective treatment to reduce the interocular difference of AL in eyes with axial anisometropia. This pilot study provides useful information for future prospective and larger studies of atropine for the treatment of pediatric axial anisometropia.

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Relative corneal refractive power shift and inter-eye differential axial growth in children with myopic anisometropia treated with bilateral orthokeratology

Lin,

Li,

Liu

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose To investigate the relationship between relative corneal refractive power shift (RCRPS) and axial length growth (ALG) in bilateral myopic anisometropes treated with orthokeratology. Methods A total of 102 children with myopic anisometropia in this prospective interventional study were randomly assigned to the spectacle group and orthokeratology group. Axial length (AL) and corneal topography was measured at baseline and the 12-month follow-up visit. ALG was defined as the difference between the two measurements, and RCRPS profiles were calculated from two axial maps obtained. Results In the orthokeratology group, the ALG in the more myopic eye (0.06 ± 0.15 mm) was significantly smaller than that in the less myopic eye (0.15 ± 0.15 mm, p < 0.001), and the interocular difference in AL significantly decreased following 1-year treatment, from 0.47 ± 0.32 to 0.38 ± 0.28 mm (p < 0.001). However, in the spectacle group, the ALG was similar between the two eyes, and the interocular difference in AL did not change significantly over one year (all p > 0.05). The interocular difference in ALG in the orthokeratology group was significantly correlated with the interocular difference in RCRPS (dRCRPS, β=−0.003, p < 0.001) and the interocular difference in baseline AL (β=−0.1179, p < 0.001), with R2 being 0.6197. Conclusion Orthokeratology was effective in decreasing the magnitude of anisometropia. The interocular variation in RCRPS is an important factor accounting for the reduction of interocular ALG difference in anisomyopic children post-orthokeratology. These results provide insight into establishing eye-specific myopia control guidelines during orthokeratology treatment for myopic anisometropes.

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Assessing the change of anisometropia in unilateral myopic children receiving monocular orthokeratology treatment

Cited by 20 publications

References 28 publications

A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children

A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children

Evaluation of axial length to identify the effects of monocular 0.125% atropine treatment for pediatric anisometropia

Relative corneal refractive power shift and inter-eye differential axial growth in children with myopic anisometropia treated with bilateral orthokeratology

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