A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children

Tsai, Wei-Shan; Wang, Jen-Hung; Chiu, Cheng-Jen

doi:10.1038/s41598-020-71142-3

Cited by 13 publications

(10 citation statements)

References 37 publications

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“…51,52 Moreover, appropriate asymmetric optical manipulations by orthokeratology were found to reduce the degree of anisomyopia in children. [53][54][55] It is possible that such treatments differentially affect the magnitude of choroidal thickening. 13,14 Orthokeratology treatments have been shown to increase ChT in a period as short as 3 to 4 weeks, [56][57][58] and this effect was sustained over the 1-year treatment period.…”

Section: Discussionmentioning

confidence: 99%

Differences in Retinal and Choroidal Vasculature and Perfusion Related to Axial Length in Pediatric Anisomyopes

Xie

Wang

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the interocular differences in choroidal vasculature, choriocapillaris perfusion, and retinal microvascular network, and to explore their associations with interocular asymmetry in axial lengths (ALs) in children with anisomyopia. METHODS.Refractive error, AL, and other biometric parameters were measured in 70 children with anisomyopia. Using optical coherence tomography (OCT) and OCTangiography, we measured the submacular choroidal thickness (ChT), total choroidal area (TCA), luminal area (LA), stromal area (SA), choroidal vascularity index (CVI), choriocapillaris flow deficit (CcFD), retinal vessel density (VD), and foveal avascular zone (FAZ) area. RESULTS.The mean interocular differences in spherical equivalent refraction and AL were −2.26 ± 0.94 diopters and 0.95 ± 0.46 mm, respectively. Submacular ChT, TCA, LA, SA, and CVI were all significantly lower in the more myopic (longer AL) eyes than in the less myopic (shorter AL) fellow eyes. In eyes with longer ALs, both the CcFD and FAZ areas were significantly greater, whereas the superficial and deep retinal VDs were significantly less. After adjusting for corneal power and intraocular pressure, interocular differences in LA (β = −0.774), SA (β = −0.991), and CcFD (β = 0.040) were significantly associated with interocular asymmetry in AL (all P < 0.05). CONCLUSIONS.In pediatric anisomyopes, eyes with longer ALs tended to have lower choroidal vascularity and choriocapillaris perfusion than the contralateral eyes with shorter ALs. Longitudinal investigations would be useful follow-ups to test for a causal role of choroidal circulation in human myopia.

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Section: Discussionmentioning

confidence: 99%

Differences in Retinal and Choroidal Vasculature and Perfusion Related to Axial Length in Pediatric Anisomyopes

Xie

Wang

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…Orthokeratology is a particular type of contact lens prescription that is commonly utilized by a majority pediatric ophthalmologists to facilitate the control of myopia progression [30, 31]. Furthermore, recent retrospective research has determined that orthokeratology is beneficial in minimizing the inter-ocular difference in AL in myopic children, owing to a stronger retardation impact on axial elongation in the more myopic eyes [32, 33]. However, poor compliance and intolerance to their use for younger age groups can result in the treatment becoming difficult to maintain over time.…”

Section: Discussionmentioning

confidence: 99%

Effect of Atropine 0.01% Eye Drops on the Difference in Refraction and Axial Length between Right and Left Eyes

Liang

Wei

et al. 2023

Ophthalmic Res

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Introduction: This study sought to determine whether the application of 0.01% atropine eye drops could impact the disparity in refraction and axial length (AL) between the right and left eyes in Chinese children. Methods: The study was designed as a double-blind, placebo-controlled randomized trial. A total of 220 children aged 6-12 years were recruited from the Beijing Tongren Hospital in Beijing, China. Participants were randomized in a 1:1 ratio and were prescribed 0.01% atropine or placebo eye drops to be administered once a night to both eyes for the duration of one year. The cycloplegic refraction and AL was recorded including baseline, 6 months, and again at the twelve months. Results: After one-year follow-up period, 76 (69%) and 83 (75%) subjects of the initial 220 participants were identified as the 0.01% atropine and placebo groups, respectively. The inter-ocular difference in spherical equivalent refraction (SER) and AL demonstrated stable values in the 0.01% atropine treatment group (SER: p=0.590; AL: p=0.322) analyzed after one-year, but found a significant increase (SER: p<0.001; AL: p=0.001) in the placebo group. Furthermore, over one year, eyes with greater myopia in the atropine group exhibited slower myopia progression (0.45±0.44D) than the lesser myopic eye (0.56±0.44D) (p=0.003). Conclusion: This study demonstrated that 0.01% atropine could maintain the inter-ocular SER and AL difference. And 0.01% atropine appeared to be more effective in delaying the progression of myopia in eyes with more myopia than in the less myopic eyes.

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“…Hence it was suggested that Ortho-k might be a better choice in reducing the degree of anisomyopia and the progression of myopia. 2 Depending on how the twin sisters respond to low dose atropine, the Ortho-k or combined treatment strategies could be tried during the subsequent visits, as the twin sisters are at risk of developing further retinal complications due to pathological myopia.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Anisomyopia in Identical Twins and Management: A Case Report

Sivaraman¹,

Balaji²

2022

Preprint

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A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children

Cited by 13 publications

References 37 publications

Differences in Retinal and Choroidal Vasculature and Perfusion Related to Axial Length in Pediatric Anisomyopes

Differences in Retinal and Choroidal Vasculature and Perfusion Related to Axial Length in Pediatric Anisomyopes

Effect of Atropine 0.01% Eye Drops on the Difference in Refraction and Axial Length between Right and Left Eyes

Clinical Characteristics of Anisomyopia in Identical Twins and Management: A Case Report

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