Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace

Liao, Chung‐Min; Chiang, Yu-Hui; Chio, Chia-Pin

doi:10.1016/j.jhazmat.2008.05.020

Cited by 57 publications

(35 citation statements)

References 39 publications

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“…2008;Brouwer et al, 2009;Liao et al, 2009;Curwin and Bertke, 2011;Lee et al, 2011;Ling et al, 2011;Zang et al, 2011, Dylla andHassan, 2012;Koivisto et al, 2012a, b) and do not always clearly differentiate ambient from engineered particles.…”

Section: Measurement Strategymentioning

confidence: 99%

Measurements of Nanoscale TiO2 and Al2O3 in Industrial Workplace Environments - Methodology and Results

Kaminski

Beyer

Fißan

et al. 2015

Aerosol Air Qual. Res.

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The possible release of engineered nanomaterials was investigated based on a previously developed but now refined methodology. Data from altogether eight industrial work areas in production plants of nanostructured TiO 2 and Al 2 O 3 particles were obtained and used to test the methodology and to derive a first assessment of possible exposure of workers. Particle size distributions were determined in work area environments with concurrent measurements at a comparison site. Data from the comparison site were used to estimate the particle background level in the work area and distinguish it from potentially released nanomaterial. The analysis is based on the comparison of time resolved data from the work area and the comparison site as well as data determined during periods with and without work activities in the work area. The data analysis method introduced delivers size-resolved information on the potential nanoparticle exposure of workers.A significant release of particles in the size range 100-562 nm was observed in the work area of bagging aluminum oxide and is stemming from damaging or overfilling of bags, and the necessary activities during the cleaning of the work area. The maximum particle diameter of these particles was around 340 nm. At all other investigated locations no significant releases of particles in the size range 100-562 nm were determined. Also, no significant release of particles < 100 nm was observed in all work areas.The average PM 10 exposure during the work activities varied from 48 to 1,330 µg/m 3 in the different work areas. The maximum concentrations of aluminum were 118 µg/m 3 and 58 µg/m 3 for PM 10 and PM 1 , respectively, during the bagging of Al 2 O 3 in small bags. In comparison, the maximum concentrations of titanium were 550 µg/m 3 and 434 µg/m 3 for PM 10 and PM 1 , respectively, during the bagging of TiO 2 and indicate a significant release of coarser particles.

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Section: Measurement Strategymentioning

confidence: 99%

Measurements of Nanoscale TiO2 and Al2O3 in Industrial Workplace Environments - Methodology and Results

Kaminski

Beyer

Fißan

et al. 2015

Aerosol Air Qual. Res.

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“…Nanoparticles can penetrate intact skin at an occupationally relevant dose within the span of an averagelength workday. A recent study on TiO 2 nanoparticles at the workplace found that TiO 2 nanoparticles production workers have significant risk on cytotoxicity response at relatively high airborne concentrations at size range 10-30 nm [27]. Furthermore, protein tyrosine nitration is a potential hazard of nano TiO 2 on the skin, the toxicity of nano TiO 2 to skin disease should be paid more attention to in the production and utilisation process [28].…”

Section: Dermalmentioning

confidence: 99%

Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma

Song¹,

Li²,

Du³

2009

European Respiratory Journal

381

206

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Nano materials generate great benefits as well as new potential risks. Animal studies and in vitro experiments show that nanoparticles can result in lung damage and other toxicity, but no reports on the clinical toxicity in humans due to nanoparticles have yet been made.The present study aimed to examine the relationship between a group of workers' presenting with mysterious symptomatic findings and their nanoparticle exposure.Seven young female workers (aged 18-47 yrs), exposed to nanoparticles for 5-13 months, all with shortness of breath and pleural effusions were admitted to hospital. Immunological tests, examinations of bacteriology, virology and tumour markers, bronchoscopy, internal thoracoscopy and video-assisted thoracic surgery were performed. Surveys of the workplace, clinical observations and examinations of the patients were conducted.Polyacrylate, consisting of nanoparticles, was confirmed in the workplace. Pathological examinations of patients' lung tissue displayed nonspecific pulmonary inflammation, pulmonary fibrosis and foreign-body granulomas of pleura. Using transmission electron microscopy, nanoparticles were observed to lodge in the cytoplasm and caryoplasm of pulmonary epithelial and mesothelial cells, but are also located in the chest fluid. These cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs.

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“…There is no discernable relationship between agglomeration size, primary size, and crystalline structure. After cellular uptake, most TNPs are localized in endosomes [116,117] and lysosomes, while some are localized in cytoplasm [60,118] or in the peri-nuclear region [89,98] and may even penetrate into the nucleus after prolonged incubation [60,116]. The extent of TNP uptake can be diverse, depending on cell line species, TNP physicochemical properties, incubation time, and the assays used [119].…”

Section: Aggregate Sizementioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace

Cited by 57 publications

References 39 publications

Measurements of Nanoscale TiO2 and Al2O3 in Industrial Workplace Environments - Methodology and Results

Measurements of Nanoscale TiO2 and Al2O3 in Industrial Workplace Environments - Methodology and Results

Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma

The potential health risk of titania nanoparticles

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