Assessing perinatal depression as an indicator of risk for pregnancy-associated cardiovascular disease

Nicholson, Lauren; Lecour, Sandrine; Wedegärtner, Sonja Maria; Kindermann, Ingrid; Böhm, Michael; Sliwa, Karen

doi:10.5830/cvja-2015-087

Cited by 17 publications

(10 citation statements)

References 39 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is, however, a paucity of data on the involvement of O & NS processes in perinatal depression. There is one paper hypothesizing that increased oxidative stress in perinatal depression could contribute to cardiovascular pathology in women with pre-eclampsia (Nicholson et al, 2016). Nevertheless, elevated O & NS in pregnancy may have detrimental effects by increasing the risk towards perinatal depression and physio-somatic symptoms.…”

Section: Introductionmentioning

confidence: 99%

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby

Roomruangwong

Barbosa

Matsumoto

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby

Roomruangwong

Barbosa

Matsumoto

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

“…No previous studies have investigated oxidative stress in perinatal depression. Nevertheless, a hypothesis had been proposed describing a possible relationship between perinatal depression, oxidative stress, and risk for pregnancy-associated cardiovascular diseases (CVD) (Nicholson et al 2016). An animal study showed an association of lowered maternal care, a possible indicator of maternal emotional problems, and increased oxidative stress in the brain of nursing mothers (Nicholson et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, a hypothesis had been proposed describing a possible relationship between perinatal depression, oxidative stress, and risk for pregnancy-associated cardiovascular diseases (CVD) (Nicholson et al 2016). An animal study showed an association of lowered maternal care, a possible indicator of maternal emotional problems, and increased oxidative stress in the brain of nursing mothers (Nicholson et al 2016). It is not unlikely that lowered IgM-mediated regulatory responses during pregnancy may play a role in the increased incidence of cardiovascular complications during pregnancy and in women of childbearing age (Mohamed 2014).…”

Section: Discussionmentioning

confidence: 99%

IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway

et al. 2017

View full text Add to dashboard Cite

Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.

show abstract

“…Perinatal depression may contribute to increased CVD risk in women through inflammatory changes that promote hypertension in the form of preeclampsia and the development of gestational diabetes, but this has yet to be directly tested. 143,144 The following two sections will summarize the recent advances in the literature pertaining to depression and CVD risk in gestational diabetes and preeclampsia.…”

Section: Perinatal Depressionmentioning

confidence: 99%

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Mattina

Lieshout

Steiner

2019

Therapeutic Advances in Cardiovascular Disease

View full text Add to dashboard Cite

Women are at increased risk for developing depression and cardiovascular disease (CVD) across the lifespan and their comorbidity is associated with adverse outcomes that contribute significantly to rates of morbidity and mortality in women worldwide. Immunesystem activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. This narrative review provides an updated synthesis of research examining the association of inflammation with depression and CVD, and their comorbidity in women. Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. Changes to inflammatory cytokines in relation to reproductive periods of hormonal fluctuation (i.e. the menstrual cycle, perinatal period and menopause) are highlighted and provide a greater understanding of the unique vulnerability women experience in developing both depressed mood and adverse cardiovascular events. Inflammatory biomarkers hold substantial promise when combined with a patient's reproductive and mental health history to aid in the prediction, identification and treatment of the women most at risk for CVD and depression. However, more research is needed to improve our understanding of the mechanisms underlying inflammation in relation to their comorbidity, and how these findings can be translated to improve women's health.

show abstract

Assessing perinatal depression as an indicator of risk for pregnancy-associated cardiovascular disease

Cited by 17 publications

References 39 publications

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby

IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Contact Info

Product

Resources

About