Assessing Islet Function Using 2-h Postprandial C Peptide in Type 2 Diabetes Mellitus

Abstract

Objective: This study aims to investigate the role of two-hour postprandial C-peptide C-peptide (2HPC-P) for assessing islet β-cell function in Type 2 diabetes mellitus (T2DM). Methods: A total of 326 T2DM patients were enrolled into this clinical study. The correlations were analysed between 2HPC-P, 2HPC-P increment, and 2HPC-P/fasting C-peptide (FC-P) with the area under the C-peptide curve (AUC-C) after a 100 g bread challenge. Of these patients, 87 newly diagnosed T2DM patients were divided into two Groups, Group I (2HPC-P/ FC-P ≥ 3, n = 43) and Group II (2HPC-P/FC-P < 3, n = 44), and performed insulin pumpintensive therapy for two weeks, followed by follow-up for three months.