Assessing good operating conditions for intraoperative imaging of melanoma sentinel nodes by a portable gamma camera

Riccardi, L.; Gabusi, M.; Bignotto, M.; Gregianin, Michele; Vecchiato, Antonella; Paiusco, M.

doi:10.1016/j.ejmp.2014.10.079

Cited by 7 publications

(4 citation statements)

References 21 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this view, the best trade-off strictly depends on the type of study that is planned. For example, when the predominant use of the gamma camera is SLN biopsy in patients with breast cancer or with melanoma, the most important parameter for target detection is sensitivity [34,35]. In fact, it is crucial for the gamma camera to be able to detect lymph nodes with low uptake.…”

Section: Discussionmentioning

confidence: 98%

Design and development of a dedicated portable gamma camera system for intra-operative imaging

et al. 2016

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Design and development of a dedicated portable gamma camera system for intra-operative imaging

et al. 2016

View full text Add to dashboard Cite

“…26,27 However, the low system spatial resolution provided by these SFOV gamma cameras will affect the progress of any intraoperative SLN detection procedure, i.e. even if these systems are able to detect the SLNs within a short acquisition time, they may require more time to take other views from various sides of the targeted area to distinguish the normal tissues from the abnormal tissues, particularly in situations where a SLN has been removed and the lymphatic vessels have been cut, with the possibility of more widespread distribution of the radioactivity within the surgical field.…”

Section: Discussionmentioning

confidence: 99%

Quantitative investigation of a novel small field of view hybrid gamma camera (HGC) capability for sentinel lymph node detection

Alqahtani¹,

Lees²,

Bugby³

et al. 2016

BJR

View full text Add to dashboard Cite

Objective:The hybrid gamma camera (HGC) has been developed to enhance the localization of radiopharmaceutical uptake in targeted tissues during surgical procedures such as sentinel lymph node (SLN) biopsy. To assess the capability of the HGC, a lymph node contrast (LNC) phantom was constructed to simulate medical scenarios of varying radioactivity concentrations and SLN size.Methods:The phantom was constructed using two clear acrylic glass plates. The SLNs were simulated by circular wells of diameters ranging from 10 to 2.5 mm (16 wells in total) in 1 plate. The second plate contains four larger rectangular wells to simulate tissue background activity surrounding the SLNs. The activity used to simulate each SLN ranged between 4 and 0.025 MBq. The activity concentration ratio between the background and the activity injected in the SLNs was 1 : 10. The LNC phantom was placed at different depths of scattering material ranging between 5 and 40 mm. The collimator-to-source distance was 120 mm. Image acquisition times ranged from 60 to 240 s.Results:Contrast-to-noise ratio analysis and full-width-at-half-maximum (FWHM) measurements of the simulated SLNs were carried out for the images obtained. Over the range of activities used, the HGC detected between 87.5 and 100% of the SLNs through 20 mm of scattering material and 75–93.75% of the SLNs through 40 mm of scattering material. The FWHM of the detected SLNs ranged between 11.93 and 14.70 mm.Conclusion:The HGC is capable of detecting low accumulation of activity in small SLNs, indicating its usefulness as an intraoperative imaging system during surgical SLN procedures.Advances in knowledge:This study investigates the capability of a novel small-field-of-view (SFOV) HGC to detect low activity uptake in small SLNs. The phantom and procedure described are inexpensive and could be easily replicated and applied to any SFOV camera, to provide a comparison between systems with clinically relevant results.

show abstract

“…Established methods to date make use of a γ-emitting tracer and either a γ radiation detecting probe [3,4] or a portable gamma camera [5,6]. Since γ radiation can travel through a large amount of tissue, any uptake of the tracer in nearby healthy tissue represents a non-negligible background, limiting and sometimes preventing the use of this technique.…”

mentioning

confidence: 99%

The β- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

et al. 2019

View full text Add to dashboard Cite

Radio-guided surgery with − β decays is a novel technique under investigation. One of the main advantages is its capability to detect small (⩽ 0.1 ml) samples after injecting the patient with low activity of radiopharmaceutical. This paper presents an experimental method to quantify this feature based on ex-vivo tests on specimens from meningioma patients. Methods: Patients were enrolled on the basis of the standard uptake value (SUV) and the tumour-to-non-tumour activity ratio (TNR) resulted from 68 Ga-DOTATOC PET exams. After injecting the patients with 93-167 MBq of 90 Y-DOTATOC, 26 samples excised during surgery were analyzed with a − β probe. The radioactivity expected on the neoplastic specimens was estimated according to the SUV found in the PET scan and the correlation with the measured counts was studied. The doses to surgeon and medical personnel were also evaluated. Results: Even injecting as low as 1.4 MBq/kg of radiotracer, tumour residuals of 0.1 ml can be detected. A negligible dose to the medical personnel was confirmed. Conclusions: Radio-guided surgery with − β decays is a feasible technique with a low radiation dose for both personnel and patient, in particular if the patient is injected with the minimum required activity. A correlation greater than 80% was observed between the measured counts and the expected activity for the lesion samples based on the individual SUV and the TNR. This makes identifiable the minimum injectable radiotracer activity for cases where 90 Y is the utilized radionuclide. 1. Background Radio-guided surgery (RGS) is a technique aimed at assisting the surgeon to reach as complete a resection of the tumoural lesion as possible, while minimizing the amount of healthy tissue removed[1]. Before surgery, the patient is administered with a specific radio-labeled tracer which is preferentially absorbed by the tumoural tissue. A probe (for a review see [2]), sensitive to the signal emitted by the radio-tracer, is used to identify the radio-marked tumour lesion. As a result, after the bulk removal, RGS provides the surgeon with real-time information

show abstract

Assessing good operating conditions for intraoperative imaging of melanoma sentinel nodes by a portable gamma camera

Cited by 7 publications

References 21 publications

Design and development of a dedicated portable gamma camera system for intra-operative imaging

Design and development of a dedicated portable gamma camera system for intra-operative imaging

Quantitative investigation of a novel small field of view hybrid gamma camera (HGC) capability for sentinel lymph node detection

The β- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test

Contact Info

Product

Resources

About