Assessing gastrointestinal motility in healthy horses comparing auscultation, ultrasonography and an acoustic gastrointestinal surveillance biosensor: a randomised, blinded, controlled crossover proof of principle study

VanderBroek, Ashley R.; Reef, Virginia B.; Aitken, Maia R.; Stefanovski, Darko; Southwood, Louise L.

doi:10.1111/evj.12990

Cited by 12 publications

(17 citation statements)

References 24 publications

(34 reference statements)

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“…HR, RR, and GI motility were all evaluated based on auscultation. Auscultation for GI motility was performed using a stethoscope and listening to the four abdominal quadrants (right and left paralumbar fossa and caudoventral abdomen) for the duration of 1 min (Vanderbroek et al., 2019). Motility was based on a score of 0–3 from a scoring system that was previously published (Sasaki et al., 2008).…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses

Shane

Langston

Wills

et al. 2021

Vet Pharm & Therapeutics

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An ideal dexmedetomidine protocol has yet to be determined for standing sedation in horses. It was hypothesized that an IV bolus followed by CRI dexmedetomidine would have a quicker increase in plasma concentrations compared with repeated IM injections. In a crossover design, eight adult, female horses were randomly placed into two groups: the CRI group (IV bolus dexmedetomidine at 0.005 mg/kg followed by a CRI at 0.01 mg/kg/h for 15 min then 0.005 mg/kg/h for 60 min) and the IM group (dexmedetomidine at 0.01 mg/kg, followed by 0.005 mg/kg in 30‐min intervals for 60 min). Clearance and elimination half‐life were 134 ± 67.4 ml/kg/min and 44.3 ± 26.3 min, respectively, in the CRI group, and apparent clearance and half‐life were 412 ± 306 ml/kg/min (Cl/F) and 38.9 ± 18.6 min, respectively, in the IM group. Analgesia was evaluated using mechanical pressure threshold. Intravenous dexmedetomidine produced faster onset of sedation and increased pressure threshold compared with IM administration. Individual horses had a large variability in dexmedetomidine plasma concentrations between CRI and IM administration. The odds of a decreased GI motility following IV administration was 12.34 times greater compared with IM administration.

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Section: Methodsmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses

Shane

Langston

Wills

et al. 2021

Vet Pharm & Therapeutics

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“…Ultrasonographic examination is more sensitive and objective to detect changes in intestinal motility than intestinal auscultation (Reef, 1998;Jones et al, 2003). Auscultation is a subjective method and depends on the performer (Vanderbroek et al, 2018). At ultrasonographic examination, the duodenum motility presented a significant increase in MS and DSS groups when compared to the control group 12 hours after administration (P=0.0432).…”

Section: Resultsmentioning

confidence: 99%

Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses

Alonso

Esper

Rosa

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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Magnesium sulphate (MS) and dioctyl sodium sulphosuccinate (DSS) are laxative drugs frequently used for the treatment of impactions. The aim of this study was to compare the effects of MS and DSS in fecal hydration, output and systemic hydration in healthy horses. Five healthy horses received 3 treatments with a 21-day interval. Treatment 1 was performed with administration of 4 liters of warm water; treatment 2: administration of 4 liters of warm water associated with 1g/kg of MS; and treatment 3: administration of 4 liters of warm water associated with 20mg/kg DSS. General and specific physical examination of the digestive system were performed, alongside with packed cell volume and total plasma protein measurement, abdominal ultrasonography and quantification of the amount and hydration of feces, before and 6, 12, 24, 36 and 48 hours after the treatments. No adverse effects were observed. The administration of laxatives promoted greater fecal output and hydration without resulting in systemic dehydration, yet no differences were observed between treatments. The absence of adverse effects of DSS demonstrates the safety of its use as a laxative drug at a dose of 20mg/kg. Studies comparing the effects of the laxative drugs in horses with large colon impaction are needed.

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“…This was done in a paper by VanderBroek, et al . by randomising as many variables as possible . By comparing sedated to unsedated horses and not disclosing this information until after the study was complete, sensitivity, specificity and accuracy could be compared between auscultation, ultrasonography and the biosensors with a minimal amount of bias.…”

Section: Mitigation Strategiesmentioning

confidence: 99%

How to publish diagnostic imaging studies: Common mistakes and recommendations

Pease

Marr

2018

Equine Veterinary Journal

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Assessing gastrointestinal motility in healthy horses comparing auscultation, ultrasonography and an acoustic gastrointestinal surveillance biosensor: a randomised, blinded, controlled crossover proof of principle study

Abstract: In this proof of principle study, AGIS was able to discriminate between horses given xylazine from those given 0.9% NaCl with comparable accuracy as auscultation and ultrasonography. The Summary is available in Spanish - see Supporting Information.

Cited by 12 publications

References 24 publications

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses

Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses

How to publish diagnostic imaging studies: Common mistakes and recommendations

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