Assessing breast tissue oxygenation using inspired gas stimulation with NIR tomography

Jiang, Shudong; Frazee, Tracy E.; Jermyn, Michael; Michaelsen, Kelly E.; Pogue, Brian W.; Paulsen, Keith D.; Kaufman, Peter A.

doi:10.1117/12.874804

Cited by 1 publication

(2 citation statements)

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“…As such, techniques for the visualization of the distribution of partial pressure of oxygen in tumors are of significant interest in pre-clinical and clinical research. To date, several non-invasive methods for oxygen-sensitive imaging have been reported, including near-infrared spectroscopy (NIRS) [2], fluorescence/phosphorescence imaging [3], positron emission tomography (PET) using hypoxia radiotracers [4], 19 F-magnetic resonance imaging (MRI) [5], blood oxygen level-dependent MRI [6], and electron paramagnetic resonance (EPR) imaging [7,8]. Of these imaging modalities, EPR is one of the few methods that enable quantitative visualization of the partial pressure of oxygen in tumors.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous T2* mapping of 14N- and 15N-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging

Yokoyama

Taguchi

Kubota

et al. 2019

Journal of Magnetic Resonance

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This article reports a method of simultaneous T 2 * mapping of 14 N-and 15 N-labeled dicarboxy-PROXYLs using 750-MHz continuous-wave electron paramagnetic resonance (CW-EPR) imaging. To separate the spectra of 14 N-and 15 N-labeled dicarboxy-PROXYLs under magnetic field gradients, an optimization problem for spectral projections was formulated with the spatial total variation as a regularization term and solved using a local search based on the gradient descent algorithm. Using the single-point imaging (SPI) method with spectral projections of each radical, simultaneous T 2 * mapping was performed for solution samples. Simultaneous T 2 * mapping enabled visualization of the response of T 2 * values to the level of dissolved oxygen in the solution. Simultaneous T 2 * mapping applied to a mouse tumor model demonstrated the feasibility of the reported method for potential application to in vivo oxygenation imaging.

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Section: Introductionmentioning

confidence: 99%

“…Nevertheless, we note that the computationally derived spectral projections can be adapted to the measured spectra. The effect of a change in zero-gradient spectra at each point is mostly compensated for adapting the projected profile of EPR signals (g) due to the fidelity term in Eq (2)…”

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confidence: 99%