This article reports a method of simultaneous T 2 * mapping of 14 N-and 15 N-labeled dicarboxy-PROXYLs using 750-MHz continuous-wave electron paramagnetic resonance (CW-EPR) imaging. To separate the spectra of 14 N-and 15 N-labeled dicarboxy-PROXYLs under magnetic field gradients, an optimization problem for spectral projections was formulated with the spatial total variation as a regularization term and solved using a local search based on the gradient descent algorithm. Using the single-point imaging (SPI) method with spectral projections of each radical, simultaneous T 2 * mapping was performed for solution samples. Simultaneous T 2 * mapping enabled visualization of the response of T 2 * values to the level of dissolved oxygen in the solution. Simultaneous T 2 * mapping applied to a mouse tumor model demonstrated the feasibility of the reported method for potential application to in vivo oxygenation imaging.
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