Assessing awareness in early-stage Alzheimer's disease: Development and piloting of the Memory Awareness Rating Scale

Clare, Linda; Wilson, Barbara A.; Carter, Gina; Roth, Ilona; Hodges, John R.

doi:10.1080/09602010244000129

Cited by 90 publications

(100 citation statements)

References 42 publications

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“…Studies would benefit, though, from assessing anosognosia in more than one way for all participants. When doing so, isomorphism in the measures used is recommended [32]. As found in the present and also previous studies, anosognosia for different dimensions can be assessed, and those different aspects can, in fact, be associated with different variables [3,7,33].…”

Section: Future Directions and Research Implicationsmentioning

confidence: 86%

The Longitudinal Association Between a Discrepancy Measure of Anosognosia in Patients with Dementia, Caregiver Burden and Depression

Perales

Turró‐Garriga

Gascón‐Bayarri

et al. 2016

JAD

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Abstract.Background: According to cross-sectional studies, there is an association between anosognosia in people with dementia and caregiver's burden and depression. Anosognosia in patients may be a cause of caregiver burden and depression. However, variability in caregiver anosognosia ratings may exist as caregivers with burden and depression may have a more pessimistic view of the patients' health. Objective: To assess the variability of caregiver anosognosia ratings of patients with dementia using a widely used anosognosia scale and its longitudinal relationship with caregiver burden and depression. Methods: A convenience cohort of 221 consecutive dementia outpatient and caregiver dyads was followed up at 12 and 24 months. The main instruments used were the Anosognosia Questionnaire-Dementia (AQ-D), Caregiver Burden Interview, and Geriatric Depression Scale. Linear mixed models were used including time as a factor in every model. Multivariate analyses controlled for caregiver's socio-demographic and possible confounding factors. Results: Attrition at 12 and 24 months was 24.9% and 42.5% respectively. Patients at baseline were on average 77.8 years of age, 63.3% were women, and 63.3% had < 5 years of education. In the bivariate analyses, caregiver burden, depression, and gender were associated with caregiver ratings of total, cognitive, and personality AQ-D of the patient at different time points. Multivariate analyses revealed burden as the caregiver variable most consistently associated with total, cognitive, and personality caregiver AQ-D ratings of the patient. Conclusion: Some caregiver characteristics, especially burden, are associated with caregiver ratings of AQ-D with regard to the patient.

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Section: Future Directions and Research Implicationsmentioning

confidence: 86%

The Longitudinal Association Between a Discrepancy Measure of Anosognosia in Patients with Dementia, Caregiver Burden and Depression

Perales

Turró‐Garriga

Gascón‐Bayarri

et al. 2016

JAD

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“…The number of errors for part B (inhibition) of the task was measured. Finally, the aMCI patients" degree of awareness regarding their memory difficulties was assessed by means of the Memory Awareness Rating scale (Clare et al, 2002). The discrepancy score between the patient"s rating and a close relative"s rating was the measure of memory unawareness.…”

Section: Participantsmentioning

confidence: 99%

Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Bastin¹,

Feyers²,

Jedidi³

et al. 2012

Human Brain Mapping

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Autobiographical memory in amnestic Mild Cognitive Impairment (aMCI) is characterized by impaired retrieval of episodic memories, but relatively preserved personal semantic knowledge.This study aimed to identify (via FDG-PET) the neural substrates of impaired episodic specificity of autobiographical memories in 35 aMCI patients compared with 24 healthy elderly controls.Significant correlations between regional cerebral activity and the proportion of episodic details in autobiographical memories from two life periods were found in specific regions of an autobiographical brain network. In aMCI patients, more than in controls, specifically episodic memories from early adulthood were associated with metabolic activity in the cuneus and in parietal regions. We hypothesized that variable retrieval of episodic autobiographical memories in our aMCI patients would be related to their variable capacity to reactivate specific sensoryperceptual and contextual details of early adulthood events linked to reduced (occipito-parietal) visual imagery and less efficient (parietal) attentional processes. For recent memories (last year), a correlation emerged between the proportion of episodic details and activity in lateral temporal regions and the temporo-parietal junction. Accordingly, variable episodic memory for recent events may be related to the efficiency of controlled search through general events likely to provide cues for the retrieval of episodic details and to the ability to establish a self perspective favouring recollection.

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“…People with Alzheimer's disease and their supporters completed questionnaires which looked at perceived stigma (Stigma Impact Scale, Burgener & Berger, 2008 Bedard et al, 2001), insight (Memory Awareness Rating ScaleMemory Functioning Scale, MARS-MFS, Clare et al, 2002), and activities of daily living (Bristol Activities of Daily Living, BADLs, Bucks et al, 1996).…”

Section: Design and Protocolmentioning

confidence: 99%

Perceptions of stigma among people affected by early- and late-onset Alzheimer’s disease

Ashworth

2017

J Health Psychol

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An exploration of perceptions of stigma among people with early and late-onset Alzheimer's disease and those who support them; using questionnaires (n=44) and semi-structured interviews (n=14). Perceived stigma reporting was low in the questionnaires; whereas interviews revealed higher levels of perceived stigma in the form of unpredictable reactions to diagnosis, feeling stupid, and ignorance of the condition among the public. Perceived stigma was managed in similar ways across age groups; focusing on 'being the lucky ones'. Results support the need to further tackle stigma and challenge expectations, particularly given the drive to diagnose people and thereby expose them to stigma.

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Assessing awareness in early-stage Alzheimer's disease: Development and piloting of the Memory Awareness Rating Scale

Cited by 90 publications

References 42 publications

The Longitudinal Association Between a Discrepancy Measure of Anosognosia in Patients with Dementia, Caregiver Burden and Depression

The Longitudinal Association Between a Discrepancy Measure of Anosognosia in Patients with Dementia, Caregiver Burden and Depression

Episodic autobiographical memory in amnestic mild cognitive impairment: What are the neural correlates?

Perceptions of stigma among people affected by early- and late-onset Alzheimer’s disease

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