Assessing Autonomic Dysfunction Symptoms in Children: A Pilot Study

Ming, Xue; Bain, Jennifer; Smith, Douglas S.; Brimacombe, Michael; von-Simson, Gabrielle Gold; Axelrod, Felicia B.

doi:10.1177/0883073810381921

Cited by 33 publications

(49 citation statements)

References 13 publications

(10 reference statements)

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“…Checklists initially developed in relation to these should have increasing broad application, as should therapeutic insight 26. Indicators common in general paediatric contexts should prompt closer scrutiny (table 3).…”

Section: Recognitionmentioning

confidence: 99%

Lost among the trees? The autonomic nervous system and paediatrics

Rees

2014

Archives of Disease in Childhood

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The autonomic nervous system (ANS) has been strikingly neglected in Western medicine. Despite its profound importance for regulation, adjustment and coordination of body systems, it lacks priority in training and practice and receives scant attention in numerous major textbooks. The ANS is integral to manifestations of illness, underlying familiar physical and psychological symptoms. When ANS activity is itself dysfunctional, usual indicators of acute illness may prove deceptive. Recognising the relevance of the ANS can involve seeing the familiar through fresh eyes, challenging assumptions in clinical assessment and in approaches to practice. Its importance extends from physical and psychological well-being to parenting and safeguarding, public services and the functioning of society. Exploration of its role in conditions ranging from neurological, gastrointestinal and connective tissue disorders, diabetes and chronic fatigue syndrome, to autism, behavioural and mental health difficulties may open therapeutic avenues. The ANS offers a mechanism for so-called functional illnesses and illustrates the importance of recognising that 'stress' takes many forms, physical, psychological and environmental, desirable and otherwise. Evidence of intrauterine and post-natal programming of ANS reactivity suggests that neonatal care and safeguarding practice may offer preventive opportunity, as may greater understanding of epigenetic change of ANS activity through, for example, accidental or psychological trauma or infection. The aim of this article is to accelerate recognition of the importance of the ANS throughout paediatrics, and of the potential physical and psychological cost of neglecting it.

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Section: Recognitionmentioning

confidence: 99%

Lost among the trees? The autonomic nervous system and paediatrics

Rees

2014

Archives of Disease in Childhood

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“…In addition to pupillary pathway, ANS dysfunction in cardiovascular system has also been reported in children with ASD (Ming et al, 2011; Ming, Julu, Brimacombe, Connor, & Daniels, 2005; Bal et al, 2010). In fact, ANS in general is involved in a multitude of physiological and behavioral activities beyond the pupillary and cardiovascular controls.…”

Section: Introductionmentioning

confidence: 99%

Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders

Daluwatte

Miles

Sun

et al. 2015

Research in Developmental Disabilities

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Atypical pupillary light reflexes (PLR) has been observed in children with autism spectrum disorders (ASD), which suggests potential autonomic nervous system (ANS) dysfunction in ASD. ANS is also involved in modulating sensory processing and sensory dysfunction has been widely reported in children with ASD. However, the potential association between physiological measurements of PLR and behavioral observations (e.g. sensory behaviors) has not been examined extensively in literature. In this study, we investigated the potential correlation between PLR and frequently observed sensory behaviors in children with ASD. We found a significant association between PLR constriction amplitude and a set of sensory behaviors in the ASD group but not in typically developing children. Children with ASD who showed more atypical sensory behaviors also had smaller PLR constriction amplitudes. A smaller PLR constriction amplitude suggests lower parasympathetic modulation. This observation implies that some atypical sensory behaviors in children with ASD could be associated with decreased parasympathetic modulation.

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“…However, for Autism patients 14 out of 24 (60%) have lower ratios in the range of 1-1.19. This is clear indication of the effect of standing as natural stimulus to autonomic system to mediate the stimulus signal via baroreceptor to the heart [17][18][19]. Using coherence spectra between HRV and breathing signals are demonstrated in Figure 3.…”

Section: Discussionmentioning

confidence: 91%

“…Reduced heart rate variability has emerged as a strong indicator of risk related to adverse events in patients with range of diseases [5][6][7][8][13][14][15][16][17]. In fact, HRV analysis is a practical reproducible and considered noninvasive method to detect early autonomic dysfunction and also permitting better quantitative and qualitative evaluation of sympathovagal modulation of cardiovascular function [18]. Studies of autonomic control of autonomic function in Autism specially in children patients are few and their study population were not homogenous [19].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Autonomic Function in Children with Autism and Normal Children Using Spectral Analysis and Posture Entrainment: A Pilot Study

Kamal¹

2015

J Neurol Neurosci

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Objective: The dysfunction of the autonomic nervous system investigated in Children with Autism compared with healthy one. Cardiovascular autonomic disturbances are possibly associated with the pathogenesis of Autism in children. The purpose of this study is to use the spectral and coherence analysis of heart rate variability signal (HRV), respiration signal and peripheral blood flow signal (PBF) to assess the autonomic activity of normal children and children with Autism for the clinical usefulness of the applied methods of signal processing and timefrequency analysis for screening and treatment of Autism in children.Methods: Twenty four children who had Autism and who were not taking any medications and Twenty three age and sex matched controls (Children) were participated in this study at Department of Neurology at Johns Hopkins Hospital, Baltimore, MD, USA and Regional Medical Center, Cookeville, TN, USA. PBF and respiration signals as well as HRV signal derived from Electrocardiogram (ECG) were measured during supine and standing positions. Autopower, cross power and coherence spectra were produced to investigate the sympathetic and parasympathetic activity in both groups. Results:The results clearly indicate that in children with Autism, the coherence values are less than in control group in both low frequency (LF) and high frequency (HF) bands at coherence spectra between HRV and PBF as well as HRV and respiration in both supine and standing position. Also, the ratio of amplitude at nearly frequency of 0

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Assessing Autonomic Dysfunction Symptoms in Children: A Pilot Study

Cited by 33 publications

References 13 publications

Lost among the trees? The autonomic nervous system and paediatrics

Lost among the trees? The autonomic nervous system and paediatrics

Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders

Assessment of Autonomic Function in Children with Autism and Normal Children Using Spectral Analysis and Posture Entrainment: A Pilot Study

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