Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing

Tao, Junhua; Bauer, Daniel E.; Chiarle, Roberto

doi:10.1038/s41467-023-35886-6

Cited by 68 publications

(43 citation statements)

References 263 publications

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“…In this manner, future work is needed to provide insights into more precise, more efficient and safer editing tools. [ 58 ]…”

Section: Discussionmentioning

confidence: 99%

The research on the treatment of primary immunodeficiency diseases by hematopoietic stem cell transplantation: A bibliometric analysis from 2013 to 2022

Xu²,

et al. 2023

Medicine

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Hematopoietic stem cell transplantation (HSCT) is curative in patients with primary immunodeficiency syndrome. The safety and efficacy of HSCT as a therapeutic option for primary immunodeficiency diseases (PID) have been studied by many research groups. The purpose of our study was to perform a bibliometric analysis of research on HSCT for the treatment of PID, to assess research trends in this field, and note future research priorities. The Web of Science Core Collection (WOSCC) was used to identify relevant publications. VOSviewer and CiteSpace software were used to analyze bibliometric parameters, such as yearly records, authors, grouped authors, countries, institutions, categories and keywords. There are 602 relevant records for the last decade (2013–2022). The top 5 productive authors and high-quality paper journals are listed. Reference co-citations analysis demonstrated recent research trends were “inborn errors of immunity,” “gene editing,” and “enteropathy.” Research on HSCT for the treatment of PID has increased rapidly in the last decade, and bibliometrics are valuable for researchers to obtain an overview of hot categories, academic collaborations and trends in this study field.

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“…In this manner, future work is needed to provide insights into more precise, more efficient and safer editing tools. [ 58 ]…”

Section: Discussionmentioning

confidence: 99%

The research on the treatment of primary immunodeficiency diseases by hematopoietic stem cell transplantation: A bibliometric analysis from 2013 to 2022

Xu²,

et al. 2023

Medicine

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“…Unlike DNA editing, RNA editing offers an alternative to genome editing in certain applications in an invertible and controllable manner [ 21 ] ( Figure 2 ). First of all, recognition of RNA molecules circumvents hindrance by DNA modifications; for example, chromatin accessibility [ 22 ].…”

Section: Applications Of the Versatile Crispr-cas Rna Targeting Systemsmentioning

confidence: 99%

RNA-Dependent RNA Targeting by CRISPR-Cas Systems: Characterizations and Applications

Gunitseva

Evteeva

Borisova

et al. 2023

IJMS

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Genome editing technologies that are currently available and described have a fundamental impact on the development of molecular biology and medicine, industrial and agricultural biotechnology and other fields. However, genome editing based on detection and manipulation of the targeted RNA is a promising alternative to control the gene expression at the spatiotemporal transcriptomic level without complete elimination. The innovative CRISPR-Cas RNA-targeting systems changed the conception of biosensing systems and also allowed the RNA effectors to be used in various applications; for example, genomic editing, effective virus diagnostic tools, biomarkers, transcription regulations. In this review, we discussed the current state-of-the-art of specific CRISPR-Cas systems known to bind and cleave RNA substrates and summarized potential applications of the versatile RNA-targeting systems.

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“…This tool has made up for the shortcomings of CRISPR/ Cas9 technology in double-strand breaks, including the deletion, translocation and rupture of large fragments of genomic DNA. 15,34,35 The technique is extensively used to construct and treat disease models, especially single-gene genetic diseases. For example, Liu et al 36 packaged the most promising combination of AID-CBEmax and TMC1 guide RNA into dual-AAV using a split-intein delivery system.…”

Section: Prime Editormentioning

confidence: 99%

“…In summary, base editors are attracting considerable since their advent. This tool has made up for the shortcomings of CRISPR/Cas9 technology in double‐strand breaks, including the deletion, translocation and rupture of large fragments of genomic DNA 15,34,35 . The technique is extensively used to construct and treat disease models, especially single‐gene genetic diseases.…”

Section: Derivatives Of Crispr/cas9 Gene‐editing Strategiesmentioning

confidence: 99%

Prospects and challenges of CRISPR/Cas9 gene‐editing technology in cancer research

Ning,

Xi,

et al. 2023

Clinical Genetics

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Cancer, one of the leading causes of death, usually commences and progresses as a result of a series of gene mutations and dysregulation of expression. With the development of clustered regularly interspaced palindromic repeat (CRISPR)/Cas9 gene‐editing technology, it is possible to edit and then decode the functions of cancer‐related gene mutations, markedly advance the research of biological mechanisms and treatment of cancer. This review summarizes the mechanism and development of CRISPR/Cas9 gene‐editing technology in recent years and describes its potential application in cancer‐related research, such as the establishment of human tumor disease models, gene therapy and immunotherapy. The challenges and future development directions are highlighted to provide a reference for exploring pathological mechanisms and potential treatment protocols of cancer.

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Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing

Cited by 68 publications

References 263 publications

The research on the treatment of primary immunodeficiency diseases by hematopoietic stem cell transplantation: A bibliometric analysis from 2013 to 2022

The research on the treatment of primary immunodeficiency diseases by hematopoietic stem cell transplantation: A bibliometric analysis from 2013 to 2022

RNA-Dependent RNA Targeting by CRISPR-Cas Systems: Characterizations and Applications

Prospects and challenges of CRISPR/Cas9 gene‐editing technology in cancer research

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