Assessing amblyopia treatment using multifocal visual evoked potentials

Abstract

BackgroundTo evaluate the effect of occlusion treatment for anisometropic amblyopia using multifocal visual evoked potentials (mfVEPs).MethodsThe patients for this study comprised 19 patients (mean age 6.05 ± 1.65 years) with anisometropic amblyopia underwent mfVEP analysis using the RETIscan® system before and after occlusion treatment. After dividing the area into six ring areas and four quadrants, we analyzed the amplitudes and latencies of the mfVEPs.ResultsThe amplitudes of ring 1 (central field) in amblyopic eyes after treatment were significantly higher than those in the other rings (p = 0.001). The mfVEP amplitudes in each of the six rings between amblyopic eyes and fellow eyes at diagnosis and after occlusion treatment showed no significant differences. In quadrant 1 the amplitudes of the amblyopic eyes and fellow eyes were significantly different at the time of diagnosis (p = 0.005), whereas after occlusion treatment there was no significant difference (p = 0.888). The amplitudes for each of the six rings at diagnosis and after occlusion treatment in amblyopic eyes versus fellow eyes showed no significant difference. There were also no differences in the amplitudes in each of the four quadrants at the time of diagnosis and after occlusion treatment in amblyopic eyes versus fellow eyes. No significant difference was found in the comparison of latency values in each of the six rings or in each of the four quadrants at diagnosis and after occlusion treatment in amblyopic eyes versus their fellow eyes.ConclusionsThe amplitudes of quadrant 1 in amblyopic eyes compared with those of the fellow eyes at diagnosis were increased after occlusion treatment. Changes of the difference between amblyopic eyes and fellow eyes in quadrant 1 after occlusion treatment could be a useful, objective method for monitoring improvement in visual acuity.Electronic supplementary materialThe online version of this article (10.1186/s12886-018-0877-0) contains supplementary material, which is available to authorized users.

Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens

“…The latency of the P100 wave in amblyopia eyes is longer and the amplitude is lower than in normal eyes. Visual evoked potentials have been widely used as a diagnostic and therapeutic evaluation of amblyopia [32, 33]. In our experiment, the latency of the P100 wave in amblyopic eyes of amblyopic kittens was longer and the amplitude was lower than those in the contralateral eyes and the ipsilateral eyes of the control group, consistent with the results of previous studies.…”

Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens

“…The latency of the P100 wave in amblyopia eyes is longer and the amplitude is lower than in normal eyes. Visual evoked potentials have been widely used as a diagnostic and therapeutic evaluation of amblyopia [31,32]. In our experiment, the latency of the P100 wave in amblyopic eyes of amblyopic kittens was longer and the amplitude was lower than those in the contralateral eyes and the ipsilateral eyes of the control group, consistent with the results of previous studies.…”

Expression of brain-derived neurotrophic factor in the lateral geniculate body of monocular form deprivation amblyopic kittens

“…20 After 3 weeks of monocular deprivation, the latency of P100 in the deprived eyes was longer than that in the control group, and the amplitude decreased, which was the same as the application of PVEP in amblyopia. 21,22 Due to amblyopia, many neurons in the lateral geniculate body could not receive effective signal stimulation. Immunohistochemistry and Western blotting showed that BDNF was expressed in the cytoplasm of neurons, and the expression of BDNF in the lateral geniculate body of amblyopic cats was significantly lower than that in the control group.…”