Assembly of polymer micelles through the sol-gel transition for effective cancer therapy

Khaliq, Nisar Ul; Oh, Keun Sang; Sandra, Febrina Carolina; Joo, Yeonhee; Lee, Ju-Hyung; Byun, Youngro; Kim, In San; Kwon, Ick Chan; Seo, Jae Hong; Kim, Sang Yoon; Yuk, Soon Hong

doi:10.1016/j.jconrel.2017.04.039

Cited by 22 publications

(34 citation statements)

References 39 publications

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“…This new observation has led to the search for alternative ‘stealth’ coatings for NDDSs, including PNPs. Besides PEG, several anti-fouling polymers have been reported as potential stealth coatings for NDDS, like polybornene, polypyrrole, poloxamer, and many others [54,55,56]. Serum Albumin Coatings…”

Section: Engineering Pnps As Nddsmentioning

confidence: 99%

“…Moreover, utilization of PDT in the treatment of bulky solid tumors is subject to several limitations, including: (i) uneven and low PS accumulation in tumor tissue after systemic administration; (ii) tumor hypoxia that limits the availability of oxygen; and (iii) light penetration within the tumor mass. Therefore, the encapsulation of PS in NDDS has been used increase payloads; avoid photosensitivity by increasing targeting selectivity and reducing unspecific PS accumulation; and to perform combination therapy (e.g., chemo-PDT and photothermal therapy-PDT) [56,88,90].…”

Section: The Application Of Pnps As Ndds For Cancer Therapeutics Amentioning

confidence: 99%

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Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

et al. 2019

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In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio–nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.

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Section: Engineering Pnps As Nddsmentioning

confidence: 99%

Section: The Application Of Pnps As Ndds For Cancer Therapeutics Amentioning

confidence: 99%

Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

et al. 2019

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“…However, the poor selectivity of drugs and toxicity and side effects caused by the addition of corresponding excipients or solvents in the dosage form have limited the clinical use of many antitumor drugs to a certain extent. [5][6][7] Emodin (EM) is a natural anthraquinone compound with promising antibacterial, blood microcirculation-promoting and antitumor effects. [8][9][10] It was reported that EM can produce considerable toxicity to a variety of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo

Wei¹,

Tang²,

Li³

et al. 2021

IJN

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“…In the treatment of cancer patients, one of the most common and important methods is chemotherapy, but there are many problems regarding the use of many antitumor agents, including their hydrophobicity, low bioavailability, instability, high toxicity, severe side effects, and lack of targeted action [7][8][9]. Therefore, an important area is the development and evaluation of new delivery systems for anticancer drugs for the treatment of tumors with higher e ciency and lower toxicity.…”

Section: Introductionmentioning

confidence: 99%

Assessment of biosafety and toxicity of hydrophilic gel for implantation in experimental in vitro and in vivo models

Bezdieniezhnykh

Lykhova

Kozak

et al. 2021

Preprint

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Background: The assessment of biosafety of pharmacologically active substances is crucial for determining the feasibility of their medical use. There are controversial issues regarding the use of substances of different origins as implants. Methods: We have conducted the comprehensive studies to determine the in vivo toxicity and in vitro genotoxicity of new generation of hydrophilic gel for implantation (production name of the substance "Activegel") to detail its characteristics and assess its biosafety. Results: In vivo studies have shown the absence of clinical manifestations of intoxication in animals and no abnormalities in their physiological condition, general and biochemical blood tests. Evaluation of the site of the gel application showed no inflammatory reaction and evidenced on normal state of tissues of animal skin. The results of the genotoxicity test indicated that the gel did not affect the parameters of DNA comets and, accordingly, had no genotoxic effect on human peripheral blood lymphocytes. When studying the effect of the gel on malignantly transformed cells in vitro, it was found that the gel for implantation did not change the proliferative activity and viability of human breast cancer cells. Conclusions: Comprehensive in vitro and in vivo study using various experimental model systems showed that the hydrophilic gel for implantation "Activegel" is non-toxic.

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Assembly of polymer micelles through the sol-gel transition for effective cancer therapy

Cited by 22 publications

References 39 publications

Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo

Assessment of biosafety and toxicity of hydrophilic gel for implantation in experimental in vitro and in vivo models

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