Assay for maprotiline in human serum with improved sensitivity and selectivity

Kuss, Hans‐Joachim; Sirch, S.; D, Zhao

doi:10.1016/0378-4347(94)00071-9

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Such derivatives show antidepressant effects, being used for the treatment of disorders such as anxiety or as analgesics . The bicylo anthracene scaffold containing agent, 3‐(9,10‐dihydro‐9,10‐ethanoanthracene‐9‐yl) N ‐methylpropylamine (maprotiline) also shows antidepressant properties and imides incorporating this skeleton act as glucocorticoid receptor modulators .…”

Section: Introductionmentioning

confidence: 99%

9,10‐Dibromo‐N‐aryl‐9,10‐dihydro‐9,10‐[3,4]epipyrroloanthracene‐12,14‐diones: Synthesis and Investigation of Their Effects on Carbonic Anhydrase Isozymes I, II, IX, and XII

Göksu

Topal

Keskïn

et al. 2016

Archiv der Pharmazie

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N-substituted maleimides were synthesized from maleic anhydride and primary amines. 1,4-Dibromo-dibenzo[e,h]bicyclo-[2,2,2]octane-2,3-dicarboximide derivatives (4a-f) were prepared by the [4+2] cycloaddition reaction of dibromoanthracenes with the N-substituted maleimide derivatives. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the new derivatives were assayed against the human (h) isozymes hCA I, II, IX, and XII. All tested bicyclo dicarboximide derivatives exhibited excellent inhibitory effects in the nanomolar range, with Ki values in the range of 117.73-232.87 nM against hCA I and of 69.74-111.51 nM against hCA II, whereas they were low micromolar inhibitors against hCA IX and XII.

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Section: Introductionmentioning

confidence: 99%

9,10‐Dibromo‐N‐aryl‐9,10‐dihydro‐9,10‐[3,4]epipyrroloanthracene‐12,14‐diones: Synthesis and Investigation of Their Effects on Carbonic Anhydrase Isozymes I, II, IX, and XII

Göksu

Topal

Keskïn

et al. 2016

Archiv der Pharmazie

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“…Re commended analytical methods for maprotiline in volve mainly GC in combination with a nitrogen phosphorus detector [4][5][6], HPLC with UV [7][8][9], di od array as well as fluorescence detectors [10][11][12], HPLC with chemiluminescence [13], spectophoto metric, spectrofluorimetric [1,14], and TLC [15]. Methods included in the United States Pharmacopoe ia and European Pharmacopoeia address only the analysis of maprotiline drug substance and tablets without impurities determination in solid dosage forms [16,17].…”

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confidence: 99%