“…MSCs have been isolated from different types of human malignancies, including head and neck (Kansy et al, 2014), glioma (Behnan et al, 2014;Hossain et al, 2015;Shahar et al, 2017;Svensson et al, 2017), breast metastasis (Gonzalez et al, 2017), cervical (Avila-Ibarra et al, 2019), ovarian (McLean et al, 2011;Coffman et al, 2019;Naour et al, 2019), lung (Galland et al, 2017), prostate (Hughes et al, 2019), neuroblastoma (Pelizzo et al, 2018), and colorectal (Zhang et al, 2018) cancer. Even if the MSCs in these studies adhered to the ISCT phenotype (Dominici et al, 2006), it is important to bear in mind that tumor cells can also exhibit a mesenchymal-like phenotype, making it difficult, or even impossible, to discriminate them from MSCs.…”