Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects

Kamdje, Armel Hervé Nwabo; Etet, Paul Faustin Seke; Tagne, Richard Simo; Vecchio, Lorella; Lukong, Kiven Erique; Krampera, Mauro

doi:10.3389/fcell.2020.545126

Cited by 19 publications

(16 citation statements)

References 122 publications

(146 reference statements)

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“…Change the bone marrow microenvironment and inhibit the development of leukemia. Jafarzadeh et al, 2019;Nwabo Kamdje et al, 2020;Xia C. et al, 2020 Breast cancer Secrete exosomes to promote myeloid cells into M2-polarized breast cancer macrophages…”

Section: Cutaneous Wound Healingmentioning

confidence: 99%

“…The reprogramming of macrophages by MSCs changes the bone marrow microenvironment and inhibits the development of leukemia (Xia C. et al, 2020). In the leukemia microenvironment, leukemia cell exosomes change the immune characteristics of MSCs and macrophages (Jafarzadeh et al, 2019;Nwabo Kamdje et al, 2020). In addition, MSCs can reprogram macrophages into M2 macrophages with phagocytosis functions and can reduce the secretion of proinflammatory factors to control the tumor microenvironmental immunity (Wolfe et al, 2016;Francois et al, 2019;Wang et al, 2019).…”

Section: Hematopoietic Microenvironmentmentioning

confidence: 99%

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Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis

Liu

et al. 2021

Front. Cell Dev. Biol.

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Macrophages are involved in almost every aspect of biological systems and include development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical application prospects due to their ability to regulate adaptive and innate immune cells, particularly macrophages, and they have been used successfully for many immune disorders, including inflammatory bowel disease (IBD), acute lung injury, and wound healing, which have been reported as macrophage-mediated disorders. In the present review, we focus on the interaction between MSCs and macrophages and summarize their methods of interaction and communication, such as cell-to-cell contact, soluble factor secretion, and organelle transfer. In addition, we discuss the roles of MSC-macrophage crosstalk in the development of disease and maintenance of homeostasis of inflammatory microenvironments. Finally, we provide optimal strategies for applications in immune-related disease treatments.

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Section: Cutaneous Wound Healingmentioning

confidence: 99%

Section: Hematopoietic Microenvironmentmentioning

confidence: 99%

Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis

Liu

et al. 2021

Front. Cell Dev. Biol.

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“…Possessing important roles in tumor progression, the proportion of CA-MSCs has been demonstrated to dynamically increase throughout the distinct stages of tumor (64). Although tumor cells alone can partly "educate" the naïve MSCs to change their phenotypes and functions, the surrounding microenvironment have also emerged to play a dominant role in the malignant transition of naïve MSCs into tumoral MSCs (65,66). In various solid tumors, the TME together with tumor cells have been demonstrated to participate in promoting MSC transition into CA-MSCs (67).…”

Section: Conversion Of Naïve Mscs Into Ca-mscs By the Tmementioning

confidence: 99%

The Origins and Generation of Cancer-Associated Mesenchymal Stromal Cells: An Innovative Therapeutic Target for Solid Tumors

Yang

Zheng

et al. 2021

Front. Oncol.

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Cancer-associated mesenchymal stromal cells (CA-MSCs) have been isolated from various types of tumors and are characterized by their vigorous pro-tumorigenic functions. However, very little is known about the origins and generating process of CA-MSCs, which may facilitate the identification of biomarkers for diagnosis or innovative targets for anti-cancer therapy to restrain the tumor growth, spread and chemotherapy resistance. Current evidences have indicated that both distally recruited and local resident MSCs are the primary origins of CA-MSCs. In a tissue type-dependent mode, tumor cells together with the TME components prompt the malignant transition of tumor “naïve” MSCs into CA-MSCs in a direct cell-to-cell contact, paracrine or exosome-mediated manner. In this review, we discuss the transition of phenotypes and functions of naïve MSCs into CA-MSCs influenced by tumor cells or non-tumor cells in the TME. The key areas remaining poorly understood are also highlighted and concluded herein.

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“…Several studies have shown that BM or adipose MSCs [called adipose-derived stromal cells (ADSCs)] have a particular tropism for primary tumors (81,82). MSCs can either favor or inhibit primary tumor growth and metastasis (78,81,(83)(84)(85)s. Recent evidence has also shown that the nature of tumor cells, in particular their low or high aggressiveness, dictates the type of interactions with MSCs and notably the production of multiple chemokines and prostaglandin E2 upon release of IL-1b by tumor cells.…”

Section: Niche Cytokines and Chemokinesmentioning

confidence: 99%

Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies

Mancini¹,

Balabanian²,

Corre³

et al. 2021

Front. Immunol.

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Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in the human bone marrow, in particular in a context of hematological malignancy, is more difficult to decipher by these strategies and could benefit from the knowledge acquired on the niches of solid tumors. Indeed, some common features can be suspected, since the bone marrow is a frequent site of solid tumor metastases. Recent research on solid tumors has provided very interesting information on the interactions between tumoral cells and their microenvironment, composed notably of mesenchymal, endothelial and immune cells. This review thus focuses on recent discoveries on tumor niches that could help in understanding hematopoietic niches, with special attention to 4 particular points: i) the heterogeneity of carcinoma/cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs), ii) niche cytokines and chemokines, iii) the energy/oxidative metabolism and communication, especially mitochondrial transfer, and iv) the vascular niche through angiogenesis and endothelial plasticity. This review highlights actors and/or pathways of the microenvironment broadly involved in cancer processes. This opens avenues for innovative therapeutic opportunities targeting not only cancer stem cells but also their regulatory tumor niche(s), in order to improve current antitumor therapies.

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Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects

Cited by 19 publications

References 122 publications

Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis

Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis

The Origins and Generation of Cancer-Associated Mesenchymal Stromal Cells: An Innovative Therapeutic Target for Solid Tumors

Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies

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