Aspirin esterase activity — Evidence for skewed distribution in healthy volunteers

Adebayo, Gani I.; Williams, John W; Healy, Selena

doi:10.1016/j.ejim.2006.12.004

Cited by 37 publications

(22 citation statements)

References 21 publications

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“…Aspirin, known as acetylsalicylic acid (ASA), is commonly used as a classic non-steroidal anti-inflammatory drug (NSAID) to relieve minor aches and treat inflammation and cardiovascular diseases [3,4]. However, this type of pharmaceutical has been detected in the aquatic environment at trace concentrations (ng to µg/L), which can prolong exposure to environmentally relevant concentration and considerably increase the toxicity considerably, resulting in negative consequences for aquatic life and human beings [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic Performance and Degradation Mechanism of Aspirin by TiO2 through Response Surface Methodology

Wang

et al. 2018

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Abstract:In the present work, the photocatalytic performance of P25TiO 2 was investigated by means of the degradation of aspirin, while the reaction system was systematically optimized by central composite design (CCD) based on the response surface methodology (RSM). In addition, three variables of initial pH value, initial aspirin concentration and P25 concentration were selected to assess the dependence of degradation efficiencies of aspirin. Meanwhile, a predicted model of degradation efficiency was estimated and checked using analysis of variance (ANOVA). The results indicated that the PC removal of aspirin by P25 was significantly influenced by all these variables in descending order as follows: P25 concentration > initial aspirin concentration > initial pH value. Moreover, the parameters were optimized by the CCD method. Under the conditions of an initial pH value of 5, initial aspirin concentration of 10 mg/L and P25 concentration of 50 mg/L, the degradation efficiency of aspirin was 98.9%with 60 min of Xenon lamp irradiation. Besides, based on the liquid chromatography-mass spectrometry measurements, two main PC degradation pathways of aspirin by TiO 2 were deduced and the tentative degradation mechanism was also proposed.

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Section: Introductionmentioning

confidence: 99%

Photocatalytic Performance and Degradation Mechanism of Aspirin by TiO2 through Response Surface Methodology

Wang

et al. 2018

Catalysts

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“…Erythrocyte Aspirin Hydrolysis Varies among IndividualsThe effectiveness of aspirin in inhibiting platelet function ex vivo varies among individuals and populations for unknown reasons (13,(42)(43)(44). We found that hydrolysis varied by over 2-fold when erythrocytes were prepared from 10 different donors (Fig.…”

Section: Resultsmentioning

confidence: 79%

Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood

Zhou

Marathe

Willard

et al. 2011

Journal of Biological Chemistry

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Background: Aspirin circulates transiently in blood, but the identity of the enzyme(s) that hydrolyzes its acetyl residue remains unknown. Results: Purification, mass spectrometry, and overexpression identified erythrocyte type I PAF acetylhydrolase as aspirin hydrolase. Conclusion: Aspirin is primarily hydrolyzed within erythrocytes by PAF acetylhydrolase. Significance: PAF acetylhydrolase and aspirin hydrolysis varies among individuals to modulate the effectiveness of aspirin.

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“…There is a wide range of rates of aspirin metabolism in the population, and ethnic and individual variations exist 7, 8. Even for a given individual, age-related factors may be also contributory to the range of turnover rates 8.…”

Section: Introductionmentioning

confidence: 99%

Serum cholesterol concentration associated with aspirin esterase activity in older people: preliminary data

Kotani¹,

Caccavello²,

Hermo³

et al. 2010

Int. J. Med. Sci.

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OBJECTIVE: Metabolism of aspirin (acetylsalicylic acid), commonly used in older people for the prevention of cardiovascular disease, is important to the effectiveness of this drug. Whereas part of aspirin hydrolysis occurs in blood, there is a paucity of information in regards to circulating aspirin esterase activity in various physiological and pathological conditions. High aspirin esterase activity, corresponding to faster aspirin hydrolysis (thus aspirin non-responsiveness), may occur in cardiovascular disease-prone states. The objective of this study was to investigate the effects of cardio-metabolic variables such as cholesterol on serum aspirin esterase activity in older people who participated in an intervention study on physical activity.METHODS: A total of 18 non-medicated subjects (7 men/11 women, mean age 67.8 years, body mass index = 23.4 ± 3.3 kg/m2), who completed a 3-month interventional program for a mild-to-moderate increase in physical activity, were analyzed. The body mass index, plasma glucose, serum total cholesterol and aspirin esterase activity were measured in the pre- and post-interventional phases of the study.RESULTS: During the interventional period, the changes in aspirin esterase activity correlated significantly and positively with those of total cholesterol concentrations (r = 0.542, P = 0.020; β = 0.609, P = 0.035 in a multiple linear regression analysis after adjusting for all the measured variables).CONCLUSION: The results suggest that cholesterol metabolism alterations may be associated with aspirin metabolism in older people.

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Aspirin esterase activity — Evidence for skewed distribution in healthy volunteers

Cited by 37 publications

References 21 publications

Photocatalytic Performance and Degradation Mechanism of Aspirin by TiO2 through Response Surface Methodology

Photocatalytic Performance and Degradation Mechanism of Aspirin by TiO2 through Response Surface Methodology

Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood

Serum cholesterol concentration associated with aspirin esterase activity in older people: preliminary data

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