Serum cholesterol concentration associated with aspirin esterase activity in older people: preliminary data

Abstract

OBJECTIVE: Metabolism of aspirin (acetylsalicylic acid), commonly used in older people for the prevention of cardiovascular disease, is important to the effectiveness of this drug. Whereas part of aspirin hydrolysis occurs in blood, there is a paucity of information in regards to circulating aspirin esterase activity in various physiological and pathological conditions. High aspirin esterase activity, corresponding to faster aspirin hydrolysis (thus aspirin non-responsiveness), may occur in cardiovascular disease-prone states. The objective of this study was to investigate the effects of cardio-metabolic variables such as cholesterol on serum aspirin esterase activity in older people who participated in an intervention study on physical activity.METHODS: A total of 18 non-medicated subjects (7 men/11 women, mean age 67.8 years, body mass index = 23.4 ± 3.3 kg/m2), who completed a 3-month interventional program for a mild-to-moderate increase in physical activity, were analyzed. The body mass index, plasma glucose, serum total cholesterol and aspirin esterase activity were measured in the pre- and post-interventional phases of the study.RESULTS: During the interventional period, the changes in aspirin esterase activity correlated significantly and positively with those of total cholesterol concentrations (r = 0.542, P = 0.020; β = 0.609, P = 0.035 in a multiple linear regression analysis after adjusting for all the measured variables).CONCLUSION: The results suggest that cholesterol metabolism alterations may be associated with aspirin metabolism in older people.

Clinical significance of pre-surgical serum lipid levels in patients with glioblastoma

“…Yang et al have suggested that aspirin could inhibit abnormal lipid metabolism in hepatocellular carcinoma cells [ 20 ]. Kotani et al have observed that in older people, serum total cholesterol metabolism alterations could be related to aspirin metabolism [ 21 ]. Moreover, Statins (inhibitors of the 3-hydroxy-3methylglutaryl coenzyme A) are very potent lipid-lowering drugs and therefore are widely used in western countries [ 22 ].…”

Anti-inflammatory and hypoglycemic efficacy of Poria cocos and Dioscorea opposita in prediabetes mellitus rats

“…9 Patients with a hyperglycemia status are considered to experience chronic inammation. 12 An activation of RAGE ligands initiates a chronic inammatory pathway that contributes to the pathogenesis of diabetic complications. RAGEs, which participate in signal transduction by activating Nuclear Factor kappa B (NF-kB), have been used for the development of various disorders.…”

“…RAGEs, which participate in signal transduction by activating Nuclear Factor kappa B (NF-kB), have been used for the development of various disorders. 12 An activation of RAGE ligands initiates a chronic inammatory pathway that contributes to the pathogenesis of diabetic complications. 13 In addition, AGEs and RAGEs promote the release of proinammatory cytokines (i.e., tumor necrosis factor-a [TNF-a], interleukin-1 [IL-1], and interleukin-6 ) by macrophages, and this triggers the recruitment of inammatory mediators and results in an acceleration of tissue dysfunction.…”

Evaluation of inflammatory conditions associated with aspirin resistance

“…Nonetheless, Kotani et al (2) have reported that decreased aspirin responsiveness was related to the increased activity of aspirin esterase in older type II diabetics, and greater aspirin hydrolysis was associated with the decreased levels of HDL cholesterol as well as increased levels of total cholesterol, thereby linking activity of aspirin esterase to cholesterol metabolism.…”