Background: Omega-3 and omega-6 fatty acids are commonly used in pregnancy, lactation, and malnutrition. Paediatrics has been investigating whether omega-3/omega-6 supplementation affects human growth and neurodevelopment in recent decades.Aims: To assess the current state of knowledge regarding the use of omega-3/omega-6 type fatty acids in the diet in adolescent and adult populations.Materials and Methods: Through September 2022, Pubmed has chosen 72 original articles on the topic of human growth and nutrition in paediatrics.Results: According to the literature, the use of omega-3/omega-6 fatty acids, with a higher prevalence in the former group than the latter, appears to be most effective in hypertension, dyslipidemia, and high C-reactive protein values, cardiovascular risk, and neuropatic pain, while having less impact on neurodegenerative (except in multiple sclerosis) and mental disorders (except in depression). Combining omega-3 and omega-6 fatty acids with spirulina algae, chitosan, probiotics, vitamin D, fibre, and plant extracts yields intriguing results.Conclusions: Although significant evidence emerges on the importance of omega-3 and omega-6 fatty acid supplementation, significant structural flaws in research designs continue to emerge from published studies; additionally, many studies assume that fatty acid supplementation can have a curative effect on already active diseases, when in fact such prescriptions should be considered as adjuvant therapies to prevent or promote symptomatic regression, precisely because of their fatty acid content. Future research that can address the critical issues raised is hoped to promote a more comprehensive approach to the topic of omega-3/omega-6 supplementation in human health.