Asphyxia as a Risk Factor for Neonatal Hypoglycemia

Mufidati, Luthfina; Anggraini, Alifah; Wibowo, Tunjung

doi:10.3126/jnps.v37i2.16581

Cited by 1 publication

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References 16 publications

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“…A state of severe acidosis can indirectly increase glycolysis and cause impaired cardiovascular function. Hypoxia that occurs also increases consumption of glucose, the combination of hypoglycemia and asphyxia increases mortality in neonatal sepsis [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Mortality of Neonatal Sepsis with Abnormal Blood Glucose Level

Adnyana¹,

Sanjaya²,

Sukmawati³

et al. 2021

AJP

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Sepsis is the third leading cause of death in neonates after asphyxia and low birth weight babies (LBW). Abnormal blood glucose, both hypoglycemia and hyperglycemia, were common metabolic changes in neonatal sepsis. This condition can higher the risk of morbidity and mortality in neonatal sepsis. The aim of this study is to prove the difference in mortality of neonatal sepsis with abnormal blood glucose compared to normal blood glucose. This was a cohort retrospective study with subjects were neonate with 28-42 weeks of gestational age with neonatal sepsis confirmed from clinical sign or blood culture at neonatal ward Sanglah hospital in the period January-August 2020. Subjects were classified as abnormal and normal blood glucose level. Chi-square test was used to assess the difference of mortality in blood glucose level. Multivariate analysis was performed with logistic regression. A total of 64 subjects with abnormal blood glucose and 64 subjects with normal blood glucose were included in this study. Mortality in subject with abnormal blood glucose was 50% and 17.2% with normal blood glucose (P<0,005). Multivariate analysis found abnormal blood glucose increases the risk of mortality 3,04 times compare with normal blood glucose (95% CI 1.09 to 8,45, P<0.033). Mechanical ventilation and asphyxia can also increase the risk of mortality in neonatal sepsis by 12,33 times (95% CI 3,99 to 38,07, P<0,001) and 8.17 times (95% CI 2,35 to 28,37, P<0,001) respectively. Subanalysis found hypoglycemia increases the risk of mortality 3.75 times compare to normoglycemia (95% CI 2.06 to 6.82, P<0.005), and hyperglycemia increases the risk of mortality 2.12 times compare to normoglycemia (95% CI 1.04 to 4.26, P=0.035). Conclusion there are significant difference of mortality in neonatal sepsis with abnormal blood glucose which is higher than normal blood glucose level. This research also found mechanical ventilation and asphyxia can effect the mortality in neonatal sepsis.

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Section: Discussionmentioning

confidence: 99%