Aspergillus sclerotiorum  : à propos d’un cas d’onychomycose en Tunisie

Amri, M.; Gorcii, Mohamed; Essabbah, N.; Belhajali, H.; Letscher-Bru, Valérie; Azaiez, R.; Babba, Hammouda

doi:10.1016/j.mycmed.2010.03.004

Cited by 9 publications

(11 citation statements)

References 17 publications

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“…The third most common species sampled was A. sclerotiorum, which has been reported to cause superficial infections, such as onychomycosis and otomycosis (10,14,15). Here, most of the isolates were also from the human respiratory tract.…”

Section: Discussionmentioning

confidence: 93%

“…This metabolite has nephrotoxic, immunosuppressive, teratogenic, and carcinogenic properties (6,7) and is commonly found in coffee, rice, beverages, and other contaminated foodstuffs (3,8). Several species in this section have been involved in different types of infections, such as onychomycosis, caused by A. insulicola, A. melleus, A. ochraceopetaliformis, A. persii, A. sclerotiorum, and A. westerdijkiae (9)(10)(11)(12)(13)(14); otomycosis, caused by A. sclerotiorum (15); skin infection, caused by A. westerdijkiae (12); and pulmonary aspergillosis and osteomyelitis, caused by A. ochraceus (16,17). Moreover, A. ochraceus, A. sclerotiorum, and A. westerdijkiae have been repetitively isolated from clinical specimens of immunocompromised patients, although in such cases their pathogenic role is uncertain (18)(19)(20)(21)(22).…”

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confidence: 99%

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Multilocus Phylogeny and Antifungal Susceptibility of Aspergillus Section Circumdati from Clinical Samples and Description of A. pseudosclerotiorum sp. nov

et al. 2017

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A multilocus phylogenetic study was carried out to assess species identity of a set of 34 clinical isolates from Aspergillus section Circumdati from the United States and to determine their in vitro antifungal susceptibility against eight antifungal drugs. The genetic markers used were the internal transcribed spacer (ITS) region, and fragments of the beta-tubulin (BenA), calmodulin (CaM), and RNA polymerase II second largest subunit (RPB2) genes. The drugs tested were amphotericin B, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, and terbinafine. The most common species sampled was A. westerdijkiae (29.4%), followed by a novel species, which was described here as A. pseudosclerotiorum (23.5%). Other species identified were A. sclerotiorum (17.6%), A. ochraceus (8.8%), A. subramanianii (8.8%), and A. insulicola and A. ochraceopetaliformis, with two isolates (5.9%) of each. The drugs that showed the most potent activity were caspofungin, micafungin, and terbinafine, while amphotericin B showed the least activity.KEYWORDS Aspergillus, Circumdati section, clinical isolates, molecular identification, phenotypic identification S ection Circumdati includes aspergilli with biseriate conidial heads in shades of yellow to ochre, with mostly globose vesicles, and sclerotia variable in shape and color (1-3). It contains 26 species (3), with A. ochraceus being the best known and described as an important producer of many extrolites, including the mycotoxin ochratoxin A (3-5). This metabolite has nephrotoxic, immunosuppressive, teratogenic, and carcinogenic properties (6, 7) and is commonly found in coffee, rice, beverages, and other contaminated foodstuffs (3,8). Several species in this section have been involved in different types of infections, such as onychomycosis, caused by A. insulicola, A. melleus, A. ochraceopetaliformis, A. persii, A. sclerotiorum, and A. westerdijkiae (9-14); otomycosis, caused by A. sclerotiorum (15); skin infection, caused by A. westerdijkiae (12); and pulmonary aspergillosis and osteomyelitis, caused by A. ochraceus (16,17). Moreover, A. ochraceus, A. sclerotiorum, and A. westerdijkiae have been repetitively isolated from clinical specimens of immunocompromised patients, although in such cases their pathogenic role is uncertain (18)(19)(20)(21)(22).There are few data on the in vitro antifungal susceptibility of species within section Circumdati. The azoles, especially itraconazole, appear to have good activity against A.

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

Multilocus Phylogeny and Antifungal Susceptibility of Aspergillus Section Circumdati from Clinical Samples and Description of A. pseudosclerotiorum sp. nov

et al. 2017

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“…En effet, certains auteurs ont étudié le profil épidémio-clinique des onychomycoses à moisissures et ont rapporté l'existence de caractéristiques communes à ce groupe d'infections : l'incidence de ces onychomycoses serait plus importante chez les adultes, en particulier après la quarantaine [2,9,24], l'atteinte du sexe féminin serait beaucoup plus fréquente que celle du sexe masculin [9] et l'atteinte des ongles des pieds (en particulier celle des gros orteils) serait prépondérante [11,24].…”

Section: Discussionunclassified

“…Les échantillons, ainsi obtenus par raclage des ongles à l'aide d'une lame de Bistouri, ont été étudiés au microscope optique après éclaircissement dans une solution de KOH à 30 %, puis inoculés dans les différents milieux (Sabouraud simple, Sabouraud chloramphenicol et Sabouraud actidione) et incubés à 27 et à 37 8C pendant trois semaines. Une moisissure est incriminée si elle est retrouvée en culture pure sur deux prélèvements successifs avec, dans les deux cas, un examen direct positif montrant des filaments mycéliens [2,3,21].…”

Section: Méthodesunclassified

Les onychomycoses à moisissure au Maroc : à propos de 150 cas isolés en 20 ans

Hajoui¹,

Zeroual²,

Ghfir³

et al. 2012

Journal de Mycologie Médicale

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“…Onychomycosis is an emerging global health problem, as it represents 50% of nail disorders1, 8, 9 and affects 2–9% of the world population 2, 10. This pathological condition affects quality of life, with loss of the patient self-esteem and may result in physical, occupational, and social limitations 2, 11, 12…”

Section: Introductionmentioning

confidence: 99%

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Caneschi

Almeida

Martins

et al. 2017

Brazilian Journal of Microbiology

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Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a–4f) and p-hydroxybenzoic acid (9a–9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series 4b–4e, mainly 4c and 4e compounds, were effective against filamentous fungi and yeast (MIC from 7.8 to 312 μg/mL). On the other hand, the amide series (9a–9f) did not present inhibitory effect against fungi, except amide 9c, which demonstrated activity only against C. albicans. This allowed us to infer that the presence of amine group and intermediate carbon number (8C–11C) in its aliphatic side chain seems to be important for antifungal activity. Although these compounds present cytotoxic activity on macrophages J774, our results suggest that these aromatic compounds might constitute potential as leader molecules in the development of more effective and less toxic analogs that could have considerable implications for future therapies of onychomycosis.

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Aspergillus sclerotiorum : à propos d’un cas d’onychomycose en Tunisie

Cited by 9 publications

References 17 publications

Multilocus Phylogeny and Antifungal Susceptibility of Aspergillus Section Circumdati from Clinical Samples and Description of A. pseudosclerotiorum sp. nov

Multilocus Phylogeny and Antifungal Susceptibility of Aspergillus Section Circumdati from Clinical Samples and Description of A. pseudosclerotiorum sp. nov

Les onychomycoses à moisissure au Maroc : à propos de 150 cas isolés en 20 ans

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

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