Aspergillus peritonitis in peritoneal dialysis patients: A systematic review

Dotis, John; Kondou, Antonia; Koukloumperi, E.; Karava, Vasiliki; Papadopoulou, Athina; Gkogka, Chrysa; Printza, Nikoleta

doi:10.1016/j.mycmed.2020.101037

Cited by 18 publications

(20 citation statements)

References 45 publications

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“…In most cases, a higher spore count was not due to the local growth of fungi, but was most probably caused by the repeated trapping and/or sedimentation of spores from the outdoor air. The identification of such hot spots is important because molds, generally, have been reported to cause systemic infections in patients undergoing peritoneal dialysis [1][2][3][4][5][6]. With that knowledge, the family could be instructed on techniques to decrease the indoor spore count.…”

Section: Summary and Interpretation Of The Results Of The Environmental Screeningmentioning

confidence: 99%

“…Repeated reports on Mucorales infections from environmental sources [71] have suggested the advantage of such approaches. Additionally, the potential risk resulting from the presence of other molds such as A. fumigatus [1][2][3][4][5][6] could be simultaneously assessed and addressed by the recommendations.…”

Section: Discussionmentioning

confidence: 99%

“…Dialysis-associated systemic mycoses have been described for various molds, including Aspergillus spp., Fusarium spp., Mucorales and Penicillium spp. [2][3][4][5][6]. Here, we describe an environmental screening process prompted by the nasal colonization of a child undergoing peritoneal dialysis with Lichtheimia corymbifera, a member of the order Mucorales; this was conducted in order to reduce the child's risk of exposure to environmental molds and the associated risk of progression to systemic infection.…”

Section: Introductionmentioning

confidence: 99%

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Risk Assessment for Molds in the Vicinity of a Child Requiring Peritoneal Dialysis Living in a Rural Northern German Area

Zautner

Frickmann

Podbielski³

2021

Microorganisms

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As well as severe immunosuppression, other predisposing factors may facilitate invasive mycosis caused by molds. Chronic kidney disease and the resulting peritoneal dialysis have been reported as factors putting patients at risk of fungal infections from environmental sources. We describe an environmental investigation undertaken to guide exposure prevention for a peritoneal dialysis patient with transient colonization of her nostrils by Lichtheimia corymbifera in a rural area of northern Germany. Systematic screening for airborne and surface-deposited molds enabled targeted recommendations to be made, although Lichtheimia corymbifera itself was not grown from the collected environmental samples. This communication is intended to illustrate how such an investigation can be performed on the basis of the environmental distribution of the molds and how preventive recommendations can be derived from the results.

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Section: Summary and Interpretation Of The Results Of The Environmental Screeningmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk Assessment for Molds in the Vicinity of a Child Requiring Peritoneal Dialysis Living in a Rural Northern German Area

Zautner

Frickmann

Podbielski³

2021

Microorganisms

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“…13 Filamentous fungi less frequently cause FP; however, different types of filamentous fungi have been reported to cause peritonitis, including Aspergillus, Paecilomyces, Penicillium, and Acremonium spp. 5,7,14 Although Aspergillus spp. rarely cause FP (2-5% of cases), it has a high morbidity and mortality rate and its diagnosis and treatment is challenging.…”

Section: Discussionmentioning

confidence: 99%

Aspergillus terreus Peritonitis in a Child on Continuous Ambulatory Peritoneal Dialysis: A Case Report from Pakistan

Moin

Moorani

Qureshi

2022

EMJ Microbiol Infect Dis

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Background: Aspergillus peritonitis is a rare, potentially fatal complication of continuous ambulatory peritoneal dialysis (CAPD). Several cases of fungal peritonitis (FP) caused by Aspergillus species have been reported worldwide; however, there is a paucity of data from Pakistan. Here, a case of congenital nephrotic syndrome is reported in a patient who progressed to Stage 5 chronic kidney disease when she was 8 years old, which was managed by CAPD and other supportive therapies. The patient developed FP and later succumbed to death despite appropriate management. Early diagnosis and careful interpretation of culture results are, therefore, important for the treatment of these patients. Case presentation: The patient outlined in this case report had congenital nephrotic syndrome, Stage 5 chronic kidney disease, and was on CAPD. She presented with peritonitis. Initially, broad spectrum antibiotics were started, and peritoneal samples did not yield any growth. Later, consecutive peritoneal samples taken from the patient grew Aspergillus terreus, with septate hyphae seen on a direct smear from the sample. Voriconazole was started immediately, and the patients’ catheter was removed. However, the patient’s condition deteriorated and, after prolonged intensive care and high ventilator support, the patient expired. Conclusion: A. terreus is an uncommon and deadly pathogen that does not respond to the commonly used antifungal treatments such as amphotericin B. The treatment of CAPD-related FP requires early diagnosis and the use of newer drugs such as voriconazole or caspofungin.

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“…An extensive literature review has also been carried out to select the articles with information on metabolites present in Aspergillus ( Supplementary Information, file “curated_references_Aspergillus_metabolome_db.csv” ) [ 53 , 54 ]. The purpose of this literature review is twofold: on the one hand, identifying new metabolites not present in the integrated databases to be added manually to the Aspergillus Metabolome Data, and on the other hand, to add meta-information relative to scientific publications where metabolites (both those found in the bibliographic review and those imported automatically) are discussed.…”

Section: Methodsmentioning

confidence: 99%

Aspergillus Metabolome Database for Mass Spectrometry Metabolomics

Gil-de-la-Fuente

Mamani-Huanca

Stroe

et al. 2021

JoF

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The Aspergillus Metabolome Database is a free online resource to perform metabolite annotation in mass spectrometry studies devoted to the genus Aspergillus. The database was created by retrieving and curating information on 2811 compounds present in 601 different species and subspecies of the genus Aspergillus. A total of 1514 scientific journals where these metabolites are mentioned were added as meta-information linked to their respective compounds in the database. A web service to query the database based on m/z (mass/charge ratio) searches was added to CEU Mass Mediator; these queries can be performed over the Aspergillus database only, or they can also include a user-selectable set of other general metabolomic databases. This functionality is offered via web applications and via RESTful services. Furthermore, the complete content of the database has been made available in .csv files and as a MySQL database to facilitate its integration into third-party tools. To the best of our knowledge, this is the first database and the first service specifically devoted to Aspergillus metabolite annotation based on m/z searches.

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Aspergillus peritonitis in peritoneal dialysis patients: A systematic review

Cited by 18 publications

References 45 publications

Risk Assessment for Molds in the Vicinity of a Child Requiring Peritoneal Dialysis Living in a Rural Northern German Area

Risk Assessment for Molds in the Vicinity of a Child Requiring Peritoneal Dialysis Living in a Rural Northern German Area

Aspergillus terreus Peritonitis in a Child on Continuous Ambulatory Peritoneal Dialysis: A Case Report from Pakistan

Aspergillus Metabolome Database for Mass Spectrometry Metabolomics

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