Aspects on the ecology of phlebotomine sand flies and natural infection by Leishmania hertigi in the Southeastern Amazon Basin of Brazil

Thies, Sirlei Franck; Bronzoni, Roberta Vieira de Morais; Michalsky, Érika Monteiro; Santos, Emerson Soares dos; Silva, David José Ferreira da; Dias, Edelberto Santos; Damazo, Amílcar Sabino

doi:10.1016/j.actatropica.2017.09.023

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…whitmani 5 , which was found to be infected by parasites of the genus Leishmania in this study. These observations have also been reported in other cities in the Amazon region such as Belém 12 , Porto Velho 13 , and Sinop 14 .…”

supporting

confidence: 82%

Preliminary observations of the urbanization and domiciliation of the American cutaneous leishmaniasis in Rio Branco, Acre, Western Amazon

Brilhante

Zampieri

Souza

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Background:The American cutaneous leishmaniasis (ACL) is expanding in peri-urban environments.Methods: An entomological survey was conducted in the area of the occurrence of an autochthonous urban case of ACL. Sandflies and a parasitological slide of the human case were submitted for molecular diagnosis.Results: Nyssomyia whitmani and Ny. antunesi were the most frequently collected species. Ny. whitmani and Bichromomyia flaviscutellata were positive for Leishmania guyanensis and L. lainsoni, respectively. The human case tested positive for L. lainsoni. Conclusions:Sandflies and Leishmania parasites present in urban forest may occur frequently in nearby domiciliary environments; thus, these areas must be monitored.

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supporting

confidence: 82%

Preliminary observations of the urbanization and domiciliation of the American cutaneous leishmaniasis in Rio Branco, Acre, Western Amazon

Brilhante

Zampieri

Souza

et al. 2022

Rev. Soc. Bras. Med. Trop.

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“…Studies carried out in forest environments showed a phlebotomine fauna generally composed of a few dominant species and many species with few specimens, corroborating our findings 31,32 . In contrast, the largest number of captured specimens was found in the urban area (89.3%) (Figure 2), and this may be due to the presence of kennels, chicken-coops and fruit trees, which present ideal characteristics for the proliferation of sand flies 33,34 . Some authors highlight the relevance of animal shelters as places for establishment and maintenance of a high sand fly density in the environment and consider these places as risk factors 11,35,36 .…”

Section: Discussionmentioning

confidence: 99%

Ecology of phlebotomine sand flies in a Brazilian area with recent leishmaniasis transmission (Itaúna, in Minas Gerais state)

Pereira

Michalsky

Lara-Silva

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…In nature, Porcisia DNA was detected by nested PCR in Lutzomyia antunesi in Brazil ( Thies et al., 2018 ). However, this finding does not imply that L. antunesi is a competent vector.…”

Section: Discussionmentioning

confidence: 99%

“…have been reported from Brazil ( Deane et al., 1974 ; Lainson and Shaw, 1977 ) and named first Leishmania hertigi deanei ( Lainson and Shaw, 1977 ), later raised to the specific status of L. deanei by Lainson and Shaw (1987) . Parasites later described in Brazil ( da Silva et al., 2013 ; Thies et al., 2018 ) as L. hertigi are probably also L. deanei . Their species identity had been based on 18S rDNA sequences, which are conserved and may not distinguish between these closely related species ( Espinosa et al., 2016 ).…”

Section: Introductionmentioning

confidence: 94%

“…Experimental studies from the 1960s-1970s described the poor development of P. hertigi and P. deanei in L. longipalpis ( Lainson et al., 1977 ; Croft and Molyneux, 1979 ) and L. sanquinaria ( Herrer et al., 1966 ). In Sinop, Brazil, Porcisia DNA was recently detected in Lutzomyia antunesi ( Thies et al., 2018 ). However, whether the parasite is able to complete development in this Lutzomyia species is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Porcisia transmission by prediuresis of sand flies

Sádlová

Bacikova

Bečvář

et al. 2022

Front. Cell. Infect. Microbiol.

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Parasites of the genus Porcisia, together with the genus Endotrypanum, form a sister clade to the species-rich and medically important genus Leishmania. Both Porcisia species, P. hertigi and P. deanei, are dixenous parasites of Neotropical porcupines. Almost 50 years after their first discovery, knowledge of their life cycle remains poor and their insect vectors are unknown. Because competent vectors of their closest phylogenetic relatives, genera Endotrypanum and Leishmania, are phlebotomine sand flies (Diptera: Psychodidae) and/or biting midges (Diptera: Ceratopogonidae), we examined here the potential of both sand flies and biting midges to transmit Porcisia parasites. The insects (Lutzomyia longipalpis, L. migonei and Culicoides sonorensis) were exposed to parasites through the chicken skin membrane and dissected at various time intervals post bloodmeal. Potentially infected females were also allowed to feed on the ears of anaesthetized BALB/c mice and the presence of parasite DNA was subsequently confirmed in the mice by PCR. Porcisia hertigi did not survive defecation in L. longipalpis or L. migonei, suggesting that these sand fly species are unlikely to serve as natural vectors of this parasite. Similarly, P. hertigi infections were lost in Culicoides midges. In contrast, mature P. deanei infections developed in 51-61% of L. longipalpis females, 7.3% of L. migonei females and 7.7% of Culicoides sonorensis females. In all three vector species, P. deanei colonized predominantly Malpighian tubules and produced metacyclic infective forms. Transmission of P. daenei to BALB/c mice was demonstrated via the prediuresis of L. longipalpis females. This mode of transmission, as well the colonization of Malpighian tubules as the dominant tissue of the vector, is unique among trypanosomatids. In conclusion, we demonstrated the vector competence of L. longipalpis for P. deanei but not for P. hertigi, and further studies are needed to evaluate competence of other Neotropical vectors for these neglected parasites.

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Aspects on the ecology of phlebotomine sand flies and natural infection by Leishmania hertigi in the Southeastern Amazon Basin of Brazil

Cited by 10 publications

References 38 publications

Preliminary observations of the urbanization and domiciliation of the American cutaneous leishmaniasis in Rio Branco, Acre, Western Amazon

Preliminary observations of the urbanization and domiciliation of the American cutaneous leishmaniasis in Rio Branco, Acre, Western Amazon

Ecology of phlebotomine sand flies in a Brazilian area with recent leishmaniasis transmission (Itaúna, in Minas Gerais state)

Porcisia transmission by prediuresis of sand flies

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