STATEMENT OF PROBLEM: Polyetheretherketone (PEEK) can be used to support fixed dental prostheses. However, information about physicomechanical characterization is still scarce. PUR-POSE: The purpose of this in vitro study was to assess effects of different aging regimens/durations on roughness, solubility, water absorption, Martens hardness (HM), and indentation modulus/EIT on different computer-aided design and computer-aided manufacturing (CAD/CAM) polymers. MATERIAL AND METHODS: Forty standardized specimens of the following materials were fabricated: PEEK: Dentokeep (DK); hybrid material: VITA Enamic (EN); composite resins: LAVA Ultimate (LU) and an experimental CAD/CAM nanohybrid-composite resin (EX); poly(methyl methacrylate) (PMMA)-based: VITA CAD-Temp (CT); Telio CAD (TC), artBloc Temp (AT), and ZENOTEC ProFix (ZP). A nanofilledpolymer for interim restorations, Protemp 4 (CG), served as the control group. Specimens were stored in sodium chloride, artificial saliva, physiological saliva, and distilled water at 37°C for 1, 7, 14, 28, 90, and 180 days. Roughness, water absorption, HM, and EIT were investigated after each storage period; solubility was determined after 180 days only. Data were analyzed using weighted 3/2/1-way ANOVA and the post hoc Scheffé tests (=.05). RESULTS: Storage media had no effect on surface roughness and water absorption. Physiological saliva revealed the highest significant impact on solubility followed by artificial saliva, sodium chloride, and distilled water. Water absorption increased significantly with storage duration. PEEK showed the lowest solubility and water absorption values. The highest solubility was observed for the conventional polymer CG, and the highest water absorption was found for the composite LU. PMMA-based TC, ZP, CG, and AT showed the lowest HM and indentation modulus, followed by CT, and PEEK. The highest values were observed for the hybrid material EN, followed by LU and EX. CONCLUSIONS: The hardness parameters of PEEK were comparable with those of PMMA-based materials. group. Specimens were stored in sodium chloride, artificial saliva, physiological saliva, and distilled water at 37°C for 1, 7, 14, 28, 90, and 180 days. Roughness, water absorption, HM, and E IT were investigated after each storage period; solubility was determined after 180 days only. Data were analyzed using weighted 3/2/1-way ANOVA and the posthoc Scheffé tests (α=05).Results. Storage media had no effect on surface roughness and water absorption.Physiological saliva revealed the highest significant impact on solubility followed by artificial saliva, sodium chloride, and distilled water. Water absorption increased significantly with storage duration. PEEK showed the lowest solubility and water absorption values. The highest ! ! ! 2! solubility was observed for the conventional polymer CG, and the highest water absorption was found for the composite LU. PMMA-based TC, ZP, CG, and AT showed the lowest HM and indentation modulus, followed by CT, and PEEK. The highest values were ...