Aspects of patient care

Evidence for a Re-Evaluation of the Neurochemical and Anatomical Bases of Chemotherapy-Induced Vomiting

“…Because it can be induced by so many diverse factors, chemotherapy-induced vomiting is the most reliable and easily reproducible side effect of cisplatin therapy and is, in fact, frequently reported by patients as both the most distressing side effect and the primary reason for prematurely dropping out of their chemotherapy. 15,16 This review will focus on the multifaceted nature of chemotherapy-induced vomiting. In summarizing this complex system, we will describe: (1) the localization, metabolism, and release of the well-investigated emetic neurotransmitters such as dopamine, serotonin, and SP; (2) the localization, metabolism, and release of the lesser known eicosanoid and endocannabinoid-related transmitters; and (3) the specific receptor subtypes identified with, or suspected of involvement in, emesis.…”

“…For example, chemotherapy-induced vomiting may involve free radical formation and/or inflammatory processes, both of which are also implicated in platin-related toxicity. − From the clinical standpoint, investigation must continue into the efficacy of various combinations of known antiemetics. Because it can be induced by so many diverse factors, chemotherapy-induced vomiting is the most reliable and easily reproducible side effect of cisplatin therapy and is, in fact, frequently reported by patients as both the most distressing side effect and the primary reason for prematurely dropping out of their chemotherapy. , …”

“…Because it can be induced by so many diverse factors, chemotherapy-induced vomiting is the most reliable and easily reproducible side effect of cisplatin therapy and is, in fact, frequently reported by patients as both the most distressing side effect and the primary reason for prematurely dropping out of their chemotherapy. 15,16 Nissar A. Darmani This review will focus on the multifaceted nature of chemotherapy-induced vomiting.…”