Aspects Of Epidermal Ultrastructure

Breathnach, A. S.

doi:10.1111/1523-1747.ep12598018

Cited by 82 publications

(19 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More recent studies have concluded, however, that the most striking difference between desmosomes in the basal, spinous, and granular layers of epithelia is quantitative rather than qualitative: in the basal layer, desmosomes are fewer than in the more superficial strata (22)(23)(24)(25)(26)(27)(28)(29)(30). In fact, desmosome morphology appears to become markedly altered only as granular cells change into keratinized squame cells (29).…”

Section: Methodsmentioning

confidence: 99%

Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma.

Parrish¹,

Garrod²,

Mattey³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma.

Parrish¹,

Garrod²,

Mattey³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…The lipid organization showing the lipid sheets was first observed under electron microscope [45,46,47], and later the regular stack of lamellar sheets was characterized [48,49]. Further understanding of the lipid organization of SC lipid lamellae was made possible by small- and wide-angle X-ray diffraction studies revealing the presence of a 13-nm lamellar phase and a long periodicity phase unique to the SC, and a 6-nm lamellar phase and a short periodicity phase in the SC lipid matrix.…”

Section: Lipid Organization In the Sc Lipid Lamellaementioning

confidence: 99%

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Tessema

Gebre‐Mariam

Neubert

et al. 2017

Skin Pharmacol Physiol

View full text Add to dashboard Cite

The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated. Recently, however, the barrier function improving effect of plant-derived CERs has attracted much attention. Phyto-derived CERs (phytoCERs) are preferable due to their assumed higher safety as they are mostly isolated from dietary sources. The beneficial effects of phytoCER-based oral dietary supplements for skin hydration and skin barrier reinforcement have been indicated in several studies involving animal models as well as human subjects. Ingestible dietary supplements containing phytoCERs are also widely available on the market. Nonetheless, little effort has been made to investigate the potential cosmetic applications of topically administered phytoCERs. Therefore, summarizing the foregoing investigations and identifying the gap in the scientific data on plant-derived CERs intended for skin-health benefits are of paramount importance. In this review, an attempt is made to synthesize the information available in the literature regarding the effects of phytoCER-based oral dietary supplements on skin hydration and barrier function with the underlying mechanisms.

show abstract

“…The molecular arrangement of the stratum corneum lipids is also highly specialized: the skin barrier lipids do not form conventional bilayers but multilamellar membranes with the first lipid layer covalently anchored to the corneocyte surface (Breathnach, 1975;Grayson and Elias, 1982). In contrast to phospholipids, the stratum corneum ceramides have a small polar head and very long, saturated chains with prevailing alltrans conformation.…”

Section: Molecular Arrangement Of the Skin Lipid Barriermentioning

confidence: 99%

Ceramides in the skin barrier

Vávrová

Kováčik

Opálka

2017

European Pharmaceutical Journal

View full text Add to dashboard Cite

The skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss from the body and entrance of undesired substances from the environment. To ensure this protective function, the composition and organization of the lipid membranes is highly specialized. The major skin barrier lipids are ceramides, fatty acids and cholesterol in an approximately equimolar ratio. With hundreds of molecular species of ceramide, skin barrier lipids are a highly complex mixture that complicate the investigation of its behaviour. In this minireview, the structures of the major skin barrier lipids, formation of the stratum corneum lipid membranes and their molecular organization are described.

show abstract

Aspects Of Epidermal Ultrastructure

Cited by 82 publications

References 58 publications

Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma.

Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma.

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Ceramides in the skin barrier

Contact Info

Product

Resources

About