Aspects of animal models for major neuropsychiatric disorders

Lefter, Radu; Cojocaru, Daniela; Ciobîcă, Alin; Paulet, Manuel; Șerban, Lăcrămioara Ionela; Anton, Emil

doi:10.2298/abs1403105l

Cited by 12 publications

(14 citation statements)

References 26 publications

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“…Regarding the animal models, and especially when we talk about the animal models mimicking the complex human neuropsychiatric disorders symptomatology, we should state from the beginning that there is impossible to perfectly replicate an animal model for a neuropsychiatric disease [29].…”

Section: Experimental Partmentioning

confidence: 99%

“…Of course, the usage of the animal models has some advantages, such as being easier to obtain, maintain and handle, less expensive and displaying increased reproductive series [29]. In this way, various animal models of schizophrenia (based for example on ketamine, methionine or phencyclidine administration), Alzheimer's disease, Parkinson's disease (e.g.…”

Section: Experimental Partmentioning

confidence: 99%

“…-by administrating dopaminergic toxins such as 6-OHDA [32,33] or MPTP [34] straight into the substantia nigra by neurosurgery), depression (e.g. the usage of forced swim test -[35]), anxiety (the usage of elevated plus maze - [36,37]) and of course autism (as we were going to insist immediately) were design based on genetic, behavioural or specific neurotransmitters manipulations [29].…”

Section: Experimental Partmentioning

confidence: 99%

See 2 more Smart Citations

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Pădurariu¹,

Antioch²,

Ciobîcă³

et al. 2017

Rev. Chim.

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There is an increased interest in the current literature in how relevant the administration of oxytocin, mostly by using its intranasal administration, could be in some neuropsychiatric disorders and especially in those manifesting a deficit at their sociability level. These aspects made the possible usage of oxytocin as extremely attractive for some management and treatment solutions in the autistic pathology. Thus, we are describing here some original data and current literature status on how oxytocin could help pathophysiological autistic manifestations in both animal models and human patients, by mainly focusing on some specific behavioural or pain manifestations and related oxidative stress status.

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Section: Experimental Partmentioning

confidence: 99%

Section: Experimental Partmentioning

confidence: 99%

Section: Experimental Partmentioning

confidence: 99%

See 1 more Smart Citation

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Pădurariu¹,

Antioch²,

Ciobîcă³

et al. 2017

Rev. Chim.

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“…Presently, the need for valid animal models for burdensome diseases that lack effective treatment is among the most pressing in research. A viable animal model must reflect disease background to a sufficient degree and feature minimum variability in order to ensure repeatable and reproducible results [1]. Furthermore, in complementary and alternative studies, a valid animal model must be as thoroughly described as possible in order to allow for the screening of positive effects as well as side effects [2].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Biochemical Description of Brain Oxidative Stress Status in Irritable Bowel Syndrome Contention-Stress Rat Model

et al. 2019

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Background and objectives: Oxidative stress and inflammation have been implicated in the etiology of irritable bowel syndrome (IBS), a common gastrointestinal functional disease. This study aimed to further characterize the contention-stress rat model by exploring a possible correlation between oxidative stress markers measured in brain tissues with behavioral components of the aforementioned model. Thus, it is hereby proposed a possible IBS animal model relevant to pharmacological and complementary medicine studies. Materials and Methods: Wild-type male Wistar rats (n = 5/group) were chronically exposed to 6-hour/day contention, consisting of isolating the animals in small, vital space-granting plastic devices, for seven consecutive days. Following contention exposure, temporal lobes were extracted and subjected to biochemical analyses to assess oxidative stress-status parameters. Results: Our results show increased brain oxidative stress in contention-stress rat model: decreased superoxide dismutase and glutathione peroxidase activities and increased malondialdehyde production in the IBS group, as compared to the control group. Furthermore, the biochemical ratios which are used to evaluate the effectiveness of an antioxidant system on oxidative stress could be described in this model. Conclusions: The correlations between the behavioral patterns and biochemical oxidative stress features could suggest that this may be a complex model, which can successfully mimic IBS symptomatology further providing evidence of a strong connection between the digestive system, enteric nervous system, and the central nervous system.

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“…To better understand of these neuropsychiatric disorders, their animal models were created. Thus, for autism (ASD), valproic acid is early used during animal's pregnancy (6). Since ancient times, medicinal plants have been medical basis for many people.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic and anti-depressant effect of Salvia spp. essential oil on rat model of Autism Spectrum Disorder

Guenné¹,

Ouédraogo²,

Lefter³

et al. 2020

BPI

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Autism or Autism Spectrum Disorder (ASD) is a human psychiatric disorder characterized by abnormal social interaction and communication with restricted repetitive behaviors. This disorder is most often accompanied by anxiety and depression. Medicinal plants have an inexhaustible potential of bioactive molecules. Salvia spp. has an essential oil with psychotropic effects. The aim of our study was to evaluate the anxiolytic and anti-depressant properties of Salvia spp. essential oil on rat model of ASD. Social interaction (SIT), elevated plus maze (EPM) and forced swim (FS) tests methods were used respectively to assess autistic, anxiety and depression status of rats. Rats with ASD spent less time in the cage containing the control rat or the new rat and more time in the empty cage in SIT compared to normal rats. Salvia spp. (3%) essential oil has anxiolytic effect by decreasing the anxiety state created by valproic acid by increasing the 20/Bulletin of Integrative Psychiatry New Series  March 2020  Year XXVI  No. 1 (84) number and time spent in the open arms (1.75±0.25; P = 0.009, F = 11.55) of the apparatus. Salvia essential oil had an antidepressant effect on VPA 500 rats with severe depression (P=0.00078, F=16.233). This oil has significantly reduced the immobility time in forced swims. This study confirmed once again the pharmacological effect of the essential oil of Salvia genus plants on the one hand and their psychotropic potential exploited in traditional medicine on the other.

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Aspects of animal models for major neuropsychiatric disorders

Cited by 12 publications

References 26 publications

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

Preliminary Biochemical Description of Brain Oxidative Stress Status in Irritable Bowel Syndrome Contention-Stress Rat Model

Anxiolytic and anti-depressant effect of Salvia spp. essential oil on rat model of Autism Spectrum Disorder

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