Aspartate aminotransferase: A prognostic marker rather than a specific liver injury marker in COVID-19

Li, Gerui

doi:10.1016/j.jinf.2020.06.007

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…This, in addition to the GGT elevation, has been described in the prior SARS outbreak [121], but is not typical of other viral hepatitis entities [122], like hepatitis B or C. It is more commonly seen in ischemic or congestive hepatopathy [123]. Therefore, direct viral injury may not be the only pathophysiology of liver injury in COVID-19 [124,125].…”

Section: Discussionmentioning

confidence: 95%

Laboratory Markers and Mortality in Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis

Joshua¹,

Shane²,

Gina³

et al. 2020

Sch J Emerg Med Crit Care

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Novel coronavirus disease 2019 (COVID-19) has caused over a million international deaths and overwhelmed healthcare systems internationally: Wuhan, China; Lombardy, Italy; and New York City, New York. This disease has led to overall mortality rates from 1-6%, [1-3] with the subset of patients who require critical care or intubation having mortality as high as 50-80% [4,5].The vast majority of patients will be asymptomatic or minimally symptomatic [6] and can be treated at home. However, a small percentage of patients will require hospitalization for aggressive supportive care -supplemental oxygen, intubation, and sometimes cardiac support [7]. Those at most risk for severe outcomes appear to be the obese, [8] the elderly, [3] and those with prior heart or lung disease [9]. Given the stretch on limited resources, predicting those at risk of de-

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Section: Discussionmentioning

confidence: 95%

Laboratory Markers and Mortality in Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis

Joshua¹,

Shane²,

Gina³

et al. 2020

Sch J Emerg Med Crit Care

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“…Alanine aminotransferase (ALT) is mainly found in hepatocytes, while aspartate aminotransferase (AST) mainly exists in the myocardium, followed by liver, kidney, and other tissues (Smith et al, 2020). Generally, the content of serum AST is low, but AST will be released into the blood when cells are injured, thus, AST is often used as a serum enzyme index for the diagnosis of liver injury (Vonbank et al, 2015;Li, 2020). Determination of serum ALT, AST, TG, and other indexes is very important for evaluation of nonalcoholic fatty liver.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Isoorientin on Oleic Acid-Induced Oxidative Damage and Steatosis in Rat Liver Cells

et al. 2022

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The harm of nonalcoholic fatty liver disease to human health is increasing, which calls for urgent prevention and treatment of the disease. Isoorientin is an effective ingredient of Chinese herbal medicine with anti-inflammatory and antioxidant effects. However, the effect of isoorientin in nonalcoholic fatty liver disease is still unclear. In this study, combined in vivo and in vitro experiments, through pathological observation, flow cytometry, immunofluorescence and western blot analysis to explore the role of isoorientin in steatosis and reveal its molecular mechanism. The results demonstrated that oleic acid treatment significantly increased the content of ROS and lipid droplets in rat hepatocytes, and promoted the expression of γH2AX, HO-1, PPARγ, SREBP-1c, FAS. The ROS content in the cells of co-treated with isoorientin and oleic acid was significantly reduced compared to the oleic acid group, and the expression of γH2AX, HO-1, PPARγ, SREBP-1c, FAS, and the nuclear translocation of NF-κB p65 were also significantly inhibited. Our data showed that oleic acid induce oxidative damage and steatosis in hepatocytes both in vitro and in vivo, and activate the PPARγ/NF-κB p65 signal pathway. Moreover, isoorientin can significantly reduce oleic acid -induced oxidative damage and steatosis by regulating the PPARγ/NF-kB p65 signal pathway.

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An uncommon case of isolated elevation of aspartate aminotransferase in a young male

Wang

Tian

et al. 2023

Intern Emerg Med

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Aspartate aminotransferase: A prognostic marker rather than a specific liver injury marker in COVID-19

Cited by 6 publications

References 4 publications

Laboratory Markers and Mortality in Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis

Laboratory Markers and Mortality in Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis

Protective Effect of Isoorientin on Oleic Acid-Induced Oxidative Damage and Steatosis in Rat Liver Cells

An uncommon case of isolated elevation of aspartate aminotransferase in a young male

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