Laboratory Markers and Mortality in Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis

Abstract

Novel coronavirus disease 2019 (COVID-19) has caused over a million international deaths and overwhelmed healthcare systems internationally: Wuhan, China; Lombardy, Italy; and New York City, New York. This disease has led to overall mortality rates from 1-6%, [1-3] with the subset of patients who require critical care or intubation having mortality as high as 50-80% [4,5].The vast majority of patients will be asymptomatic or minimally symptomatic [6] and can be treated at home. However, a small percentage of patients will require hospitalization for aggressive supportive care -supplemental oxygen, intubation, and sometimes cardiac support [7]. Those at most risk for severe outcomes appear to be the obese, [8] the elderly, [3] and those with prior heart or lung disease [9]. Given the stretch on limited resources, predicting those at risk of de-