Aspartame and Risk of Cancer: A Meta-analytic Review

Mallikarjun, Sreekanth; Sieburth, Rebecca

doi:10.1080/19338244.2013.828674

Cited by 23 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… has been heavily criticised, and it has been argued that the proposed link between aspartame consumption and brain malignancies is subject to the ecological fallacy . Most recently, a systematic review and meta‐analysis of 10 aspartame carcinogenic bioassays in rodents found that aspartame consumption has no significant carcinogenic effect .…”

Section: Discussionmentioning

confidence: 99%

“…However, studies in humans that originally demonstrated this association have since been heavily criticised , and animal data also cast doubt on the link between aspartame and cancer. An extensive meta‐analysis of aspartame carcinogenic bioassays in rodents conducted in 2013 concluded that aspartame consumption had no significant impact on cancer risk .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review of the relationship between artificial sweetener consumption and cancer in humans: analysis of 599,741 participants

2015

View full text Add to dashboard Cite

Background: The effect of artificial sweetener consumption on cancer risk has been debated in animal models for over four decades. To further investigate this relationship, this study aims to synthesise results from several of the most recent studies in humans. Methods: An online literature search was performed in MED-LINE from 2003 to 2014 using Ovid, PubMed, Web of Science, and Scopus using keywords 'artificial', 'sweetener' and 'cancer'. Ninety-two results were then manually assessed for eligibility. Studies were included if the relationship between artificial sweeteners and cancer was their central hypothesis, and if they adjusted for age, gender, smoking status and body mass index. Extracted data included study design, patient characteristics, outcome measure and results. Results: In the five publications that satisfied the inclusion criteria, significant direct associations with artificial consumption were found for laryngeal (odds ratio, OR 2.34, 95% CI: 1.20-4.55), urinary tract tumours (OR 2.12, 95% CI: 1.22-3.89), non-Hodgkin lymphoma in men (RR 1.31, 95% CI: 1.01-1.72), multiple myeloma in men (RR 2.02, 95% CI: 1.20-3.40) and leukaemia (RR 1.42, 95% CI: 1.00-2.02). Inverse relationships were found in breast (OR 0.70, 95% CI: 0.54-0.91, p trend = 0.015) and ovarian (OR 0.56, 95% CI: 0.38-0.81, p trend < 0.001) cancers. Conclusion: The statistical value of this review is limited by the heterogeneity and observational designs of the included studies. Although there is limited evidence to suggest that heavy consumption may increase the risk of certain cancers, overall the data presented are inconclusive as to any relationship between artificial sweeteners and cancer. Review criteriaData were extracted from relevant studies investigating the relationship between artificial sweeteners and cancer in humans from 2003 to 2014. The data were extracted from these studies and analysed, although gross heterogeneity in study designs precluded subsequent meta-analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systematic review of the relationship between artificial sweetener consumption and cancer in humans: analysis of 599,741 participants

2015

View full text Add to dashboard Cite

show abstract

“…91 A meta-analysis of studies of aspartame in rats showed no association between aspartame and cancer. 92 A review of human (adult) cohort and case control studies showed no relationship between most types of cancer and aspartame use. 18,51,92,93 Newer data have failed to demonstrate an association between NNS use and cancer.…”

Section: Nns Use and Cancer Riskmentioning

confidence: 99%

“…92 A review of human (adult) cohort and case control studies showed no relationship between most types of cancer and aspartame use. 18,51,92,93 Newer data have failed to demonstrate an association between NNS use and cancer. 90 The long latency period, the penetrance of NNSs into the food supply (making it difficult to isolate an adequate unexposed control group), and the diversity of potential mechanisms have made it difficult to definitively exclude potential carcinogenic properties of NNSs but also make it difficult to conclude that there is any such association.…”

Section: Nns Use and Cancer Riskmentioning

confidence: 99%

The Use of Nonnutritive Sweeteners in Children

2019

View full text Add to dashboard Cite

The prevalence of nonnutritive sweeteners (NNSs) in the food supply has increased over time. Not only are more children and adolescents consuming NNSs, but they are also consuming a larger quantity of NNSs in the absence of strong scientific evidence to refute or support the safety of these agents. This policy statement from the American Academy of Pediatrics is intended to provide the pediatric provider with a review of (1) previous steps taken for approved use of NNSs, (2) existing data regarding the safety of NNS use in the general pediatric population, (3) what is known regarding the potential benefits and/or adverse effects of NNS use in children and adolescents, (4) identified gaps in existing knowledge and potential areas of future research, and (5) suggested talking points that pediatricians may use when discussing NNS use with families This document is copyrighted and is property of the American Academy of Pediatrics and its Board of Directors. All authors have filed conflict of interest statements with the American Academy of Pediatrics. Any conflicts have been resolved through a process approved by the Board of Directors. The American Academy of Pediatrics has neither solicited nor accepted any commercial involvement in the development of the content of this publication. The guidance in this statement does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate. All policy statements from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.

show abstract

“…Az aszpartámot számos betegségcsoport -daganatok, szív-és érrendszeri betegségek, idegrendszeri és viselkedésbeli zavarok, immuneltérések, látáskárosodás, emésztési, urológiai, nőgyógyászati problémák -kialakulásának okozójaként emlegetik [55,56].…”

Section: Aszpartám (E951)unclassified

Az intenzív édesítőszerek biztonságossága

Lugasi

2016

Orvosi Hetilap

View full text Add to dashboard Cite

Napjainkban egyre nagyobb népszerűségnek örvendenek az energiamentes édesítőszerek, amelyek a vonatkozó európai uniós jogszabály alapján kerülhetnek forgalomba, illetve lehetnek részei élelmiszereinknek. Ugyanakkor egyremásra látnak napvilágot hírek arról, hogy bizonyos mesterséges intenzív édesítőszerek, köztük is elsősorban az aszpartám, rákkeltő hatással bírnak. Az energiamentes édesítőszerek, mint valamennyi más adalékanyag, kizárólag a közösségi jogszabályokban meghatározott -kockázatbecslést követő -engedélyezés után kerülhetnek fel az engedé-lyezett anyagok listájára. Ez a lista nemcsak azon élelmiszerek körét határozza meg, amelyekben az adott anyag alkalmazható, hanem a maximálisan felhasználható mennyiséget is megadja. Az Európai Unió élelmiszerekkel kapcsolatos kockázatbecslését végző hivatala, az Európai Élelmiszerbiztonsági Hatóság (European Food Safety Authority) az újonnan elvégzett tudományos vizsgálatok tükrében rendszeres időközönként újraértékeli a már engedélyezett adalékanyagok biztonságosságát. Mind ez ideig az engedélyezett, intenzív édesítőszerek biztonságos alkalmazhatósága nem vált kétségessé. Orv. Hetil., 2016, 157(Szuppl. 1.), 14-28. Kulcsszavak: intenzív édesítőszerek, kockázatbecslés, engedélyezés, EFSA Safety of intensive sweetenersNowadays low calorie or intesive sweeteners are getting more and more popular. These sweeteners can be placed to the market and used as food additives according to the recent EU legislation. In the meantime news are coming out one after the other stating that many of these artificial intensive sweeteners can cause cancer -the highest risk has been attributed to aspartam. Low calorie sweeteners, just like all the other additives can be authorized after strickt risk assessment procedure according to the recent food law. Only after the additive has gone through these procedure can be placed to the list of food additives, which contains not only the range of food these additives can be used, but also the recommended highest amount of daily consumption. European Food Safety Authority considering the latest scientific examination results, evaluates regularly the safety of sweeteners authorized earlier. Until now there is no evidence found to question the safety of the authorized intensive sweeteners. Rövidítések ADI = (acceptable daily intake) megengedhető napi bevitel; ADME = (absorption, distribution, metabolism, excretion) abszorpció, eloszlás, metabolizmus, kiválasztás; CAP = Common Authorisation Procedure; EFSA = European Food Safety Authority; EK = Európai Közösség; EOGRTS = (extended one-generation reproductive toxicity study) kiterjesztett egygenerációs reproduktív toxicitás vizsgálat; EU = European Union; FAO = Food and Agriculture Organization; FIAP = Keywords

show abstract

Aspartame and Risk of Cancer: A Meta-analytic Review

Cited by 23 publications

References 24 publications

Systematic review of the relationship between artificial sweetener consumption and cancer in humans: analysis of 599,741 participants

Systematic review of the relationship between artificial sweetener consumption and cancer in humans: analysis of 599,741 participants

The Use of Nonnutritive Sweeteners in Children

Az intenzív édesítőszerek biztonságossága

Contact Info

Product

Resources

About