Asparagine starvation suppresses histone demethylation through iron depletion

Jiang, Jie; Srivastava, Sankalp; Liu, Sheng; Seim, Gretchen; Claude, Rodney; Zhong, Minghua; Cao, Sha; Davé, Utpal P.; Kapur, Reuben; Mosley, Amber L.; Zhang, Chi; Wan, Jun; Fan, Jing; Zhang, Ji

doi:10.1016/j.isci.2023.106425

Cited by 2 publications

(1 citation statement)

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“…The latter is an intermediate of the Krebs cycle, but it is also synthesized by glutamine transamination. It has recently been demonstrated, in yeast model, that histone methylation affects the nuclear ketoglutarate availability suggesting the existence of a feedback mechanism balancing the concentration of this methyl group acceptor [21]. The concentration of α−KG it is also dependent on metabolism of glutamine, branched chain amino acids and serine [11].…”

Section: Epigenome Machinerymentioning

confidence: 99%

The Nutriepigenome

Mirisola

2023

Genes

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Unlike genetic changes, epigenetics modulates gene expression without stable modification of the genome. Even though all cells, including sperm and egg, have an epigenome pattern, most of these modifications occur during lifetime and interestingly, some of them, are reversible. Lifestyle and especially nutrients as well as diet regimens are presently gaining importance due to their ability to affect the epigenome. On the other hand, since the epigenome profoundly affects gene expression profile it can be speculated that the epigenome could modulate individual response to nutrients. Recent years have thus seen growing interest on nutrients, macronutrients ratio and diet regimens capable to affect the epigenetic pattern. In fact, while genetic alterations are mostly detrimental at the individual level, reshaping the epigenome may be a feasible strategy to positively counteract the detrimental effect of aging. Here, I review nutrient consumption and diet regimens as a possible strategy to counteract aging-driven epigenome derangement.

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Section: Epigenome Machinerymentioning

confidence: 99%