Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén

Orellana, Gloria; Sapunar, J; Sáez, Katia; Aguayo, Claudio; Calvo, Carlos; Radojkovic, Claudia; Riffo, Benilde; Gleisner, A; Asenjo, Sylvia; Ulloa, Natalia

doi:10.4067/s0034-98872012001000002

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…Hara et al [27] reported that individuals with the TG or GG genotype at position 45 have a higher risk of developing DM2 when compared to those of the TT genotype. Therefore, individuals with the G allele of the þ45T > G variant in ADIPOQ gene have lower plasma levels of adiponectin [24], which was observed in the studied SCT group. Although, without difference in the frequency of MS, the TT þ TG SCT group may present a higher risk of worsening in the long-term cardiometabolic profile, and even of MS. On the other hand, Sanch es et al [28] suggested that the presence of the G allele has a protective effect in individuals with DM2 and MS.…”

Section: Resultsmentioning

confidence: 59%

“…There are no previous studies associating the effect of the G allele of þ45T > G variant in ADIPOQ gene on adiponectin concentrations in SCT, however, it has been shown that it can alter adiponectin concentrations in other diseases and populations. The þ45T > G variant in ADIPOQ gene has been linked to the development of DM2, insulin resistance, obesity, coronary artery disease [23] and hypoadiponectinemia [24]. Paradoxically, in another type of hemoglobinopathy, beta-thalassemia, studies show that adiponectin levels are high, raising questions about their pro or anti-inflammatory role in this disease [25,26].…”

Section: Resultsmentioning

confidence: 99%

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Association between carriers of the G allele of the + 45T> G variant of the ADIPOQ gene (rs 2241766) and the cardiometabolic profile in sickle cell trait

Bruno

Ponte

Retamoso

et al. 2021

Heliyon

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Aims: investigate the association between the þ45T > G variant of the ADIPOQ gene and the metabolic syndrome (MS) in patients with sickle cell trait (SCT). 33 patients with SCT and 35 control group participated in the study. Lower levels of HDL and adiponectin were observed in patients with G allele and sickle cell trait. There were no differences between the prevalence of MS between the groups and there was no association between the þ45T > G variant of the ADIPOQ gene and MS risk allele. Materials and methods: Participants with and without sickle cell anemia answered a questionnaire, performed anthropometric and laboratory analyzes. They were genotyped for the þ45T > G variant of the ADIPOQ gene and evaluated for the presence or absence of metabolic syndrome. The study was approved by the Research Ethics Committee of UNIPAMPA (RS/Brazil). Key findings: The GG þ TG genetic model, it was associated with lower levels of adiponectin and HDL cholesterol in the SCT group. There was no association between the other studied markers and MS. Significance: For the first time, an association was demonstrated between the G allele of the þ45T > G variant of the ADIPOQ gene and a worse cardiometabolic profile (lower serum concentrations of adiponectin and HDL cholesterol) in patients with sickle cell trait.

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Section: Resultsmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Association between carriers of the G allele of the + 45T> G variant of the ADIPOQ gene (rs 2241766) and the cardiometabolic profile in sickle cell trait

Bruno

Ponte

Retamoso

et al. 2021

Heliyon

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“…Other studies reported that subjects with the T/G or G/G genotype at position 45 have a higher risk of developing DM2 when compared to those with T/T genotype 20 . Likewise, it has been observed that subjects who present the G allele of the +45T>G polymorphism have lower plasma levels of adiponectin 19 .…”

Section: Introductionmentioning

confidence: 97%

“…Several studies have determined that different polymorphisms (SNPs) have been located in the adiponectin gene, which can affect both the transcription and the activity of this hormone. Among the most prominent are the polymorphisms +45 T>G, +276 G>T, -11.377 C>G and -11.391 G>A 19 .…”

Section: Introductionmentioning

confidence: 99%

“…Studies carried out in different populations, associated the +45T>G polymorphism of the ADIPOQ gene with the development of DM2, insulin resistance, obesity, coronary artery disease and hypoadiponectinemia 19 . Other studies reported that subjects with the T/G or G/G genotype at position 45 have a higher risk of developing DM2 when compared to those with T/T genotype 20 .…”

Section: Introductionmentioning

confidence: 99%

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Association between +45T>G adiponectin polymorphism gene and type 2 diabetes mellitus and metabolic syndrome in a Venezuelan population

et al. 2019

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Background: Adiponectin (ADIPOQ) is a hormone primarily synthesized by adipocytes and encoded by the ADIPOQ gene, which exerts anti-inflammatory, antiatheratogenic and insulin sensitizing functions. It has been shown that its plasma concentrations are decreased in individuals with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2), which could be due to variations in the gene coding for this protein. The aim of this study was to detect the +45 T>G polymorphism of the ADIPOQ gene in subjects with DM2 and MS in Maracaibo municipality, Zulia state, Venezuela. Methods: A total of 90 subjects who attended the Center for Metabolic Endocrine Research "Dr. Félix Gómez" were enrolled for this study, 46 of which had MS-DM2 and 44 of which were healthy control individuals. Genomic DNA was extracted from blood samples and PCR-restriction fragment length polymorphism analysis was carried out for the promoter region of the ADIPOQ gene. Likewise, the +45 T> G polymorphism was identified and correlated with MS and DM2 in the studied population. Results: The most frequent allele in both groups was the T allele, and the predominant genotype was homozygous T/T (79%). Genotypes with heterozygous T/G and G/G homozygous polymorphism were more frequent in the control group than in the MS-DM2 group. Regarding the individuals with T/G and G/G genotypes, statistically significant lower mean values were found for fasting glucose, total cholesterol, triacylglycerides, abdominal circumference, and for the medians of systolic and diastolic blood pressure. Odds ratio were calculated for the presence or absence of MS and DM2. Conclusions: The results suggested that the presence of the G allele exerts a protective effect on the carrier individuals, thus avoiding the appearance of the aforementioned metabolic alterations.

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Adiponectin gene polymorphisms: Association with childhood obesity

Fraga

Gomes

2015

J Pediatr Genet

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The current childhood obesity epidemic represents a particular challenge for public health. Understanding of the etiological mechanisms of obesity remains integral in treating this complex disorder. In recent years, studies have elucidated the influence of hormones secreted by adipose tissue named adipokines. Adiponectin is a adipokine that exhibits important anti-inflammatory, insulin-sensitizing and anti-atherogenic properties and it is strongly associated to obesity development. It is well known that adiponectin levels decrease with obesity. Furthermore, studies show that some single nucleotide polymorphisms in the gene encoding adiponectin, ADIPOQ, may influence the expression of this protein. The objective of this paper is to provide an up-to-date review of ADIPOQ polymorphisms in the context of childhood obesity.

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Asociación entre polimorfismos del gen de adiponectina y estado nutricional en escolares de la comuna de Hualpén

Abstract: Association between adiponectin gene polymorphisms and obesity in school age children from Hualpén, Chile (Rev Med Chile 2012; 140: 1245-1252.

Cited by 4 publications

References 24 publications

Association between carriers of the G allele of the + 45T> G variant of the ADIPOQ gene (rs 2241766) and the cardiometabolic profile in sickle cell trait

Association between carriers of the G allele of the + 45T> G variant of the ADIPOQ gene (rs 2241766) and the cardiometabolic profile in sickle cell trait

Association between +45T>G adiponectin polymorphism gene and type 2 diabetes mellitus and metabolic syndrome in a Venezuelan population

Adiponectin gene polymorphisms: Association with childhood obesity

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