Asociación de polimorfismos de diaminoxidasa e histamina N metiltransferasa con la presencia, discapacidad y severidad de migraña en un grupo de madres mexicanas de niños alérgicos

Meza‐Velázquez, Rocío; López-Márquez, Francisco Carlos; Espinosa-Padilla, S; Rivera-Guillén, Mario Alberto; Ávila-Hernández, J.; Rosales-González, Manuel

doi:10.1016/j.nrl.2016.02.025

Cited by 15 publications

(6 citation statements)

References 38 publications

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“…The DAO SNP rs10156191, associated with decreased DAO enzyme activity, seemed to be more frequent in the migraine population. In the same vein, another study performed by Meza-Velázquez et al [20] also found that a mutant DAO SNP was significantly more frequent in a group of women with migraine than in the control group. Despite that published studies seem to indicate that DAO deficit could be one of the triggers for headaches, data about serum DAO activity levels in affected populations would be important to support this association.…”

Section: Discussionmentioning

confidence: 69%

Low serum diamine oxidase (DAO) activity levels in patients with migraine

et al. 2017

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Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among the several multi-faced symptoms associated with histamine intolerance, headache is one of the most recognized and disabling consequences. The aim of this study was to determine the prevalence of DAO deficiency in patients with a confirmed migraine diagnosis according to the current International Headache Society (IHS) and in non-migraine subjects. DAO activity was assessed in a total of 198 volunteers recruited at the Headache Unit of the Hospital General de Catalunya, 137 in the migraine group and 61 as a control group. DAO enzyme activity in blood samples was determined by ELISA test. Values below 80 HDU/ml (Histamine Degrading Unit/ml) were considered as DAO deficient. Mean value of DAO activity from migraine population (64.5 ± 33.5 HDU/ml) was significantly lower (p < 0.0001) than that obtained from healthy volunteers (91.9 ± 44.3 HDU/ml). DAO deficiency was more prevalent in migraine patients than in the control group. A high incidence rate of DAO deficiency (87%) was observed in the group of patients with migraine. On the other hand, 44% of non-migranous subjects had levels of DAO activity lower than 80 HDU/ml. Despite the multifactorial aetiology of migraine, these results seem to indicate that this enzymatic deficit could be related to the onset of migraine.

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Section: Discussionmentioning

confidence: 69%

Low serum diamine oxidase (DAO) activity levels in patients with migraine

et al. 2017

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“…This enzymatic deficit may have its origins in genetic mutations. Different polymorphisms of a single nucleotide in the gene that encodes this enzyme ( AOC1 on chromosome 7) have been associated with lower DAO activity [14,15,16]. The deficit may also be due to acquired causes such as inflammatory bowel diseases that block the secretion of DAO [1,3,12], or to the inhibitory action of drugs, some of them with a very widespread use (e.g., acetylcysteine, clavulanic acid, metoclopramide, verapamil) [1,17].…”

Section: Introductionmentioning

confidence: 99%

Biogenic Amines in Plant-Origin Foods: Are they Frequently Underestimated in Low-Histamine Diets?

Sánchez-Pérez

Comas-Basté

Rabell-González

et al. 2018

Foods

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Low-histamine diets are currently used to reduce symptoms of histamine intolerance, a disorder in histamine homeostasis that increases plasma levels, mainly due to reduced diamine-oxidase (DAO) activity. These diets exclude foods, many of them of plant origin, which patients associate with the onset of the symptomatology. This study aimed to review the existing data on histamine and other biogenic amine contents in nonfermented plant-origin foods, as well as on their origin and evolution during the storage or culinary process. The only plant-origin products with significant levels of histamine were eggplant, spinach, tomato, and avocado, each showing a great variability in content. Putrescine has been found in practically all plant-origin foods, probably due to its physiological origin. The high contents of putrescine in certain products could also be related to the triggering of the symptomatology by enzymatic competition with histamine. Additionally, high spermidine contents found in some foods should also be taken into account in these diets, because it can also be metabolized by DAO, albeit with a lower affinity. It is recommended to consume plant-origin foods that are boiled or are of maximum freshness to reduce biogenic amine intake.

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“…With these results, and as it was suggested in previous studies, the clinical course of AR might be altered in patients with impaired histamine metabolism [ 17 ]. There are many causes of malfunction or decrease in DAO activity [ 5 , 11 , 31 , 32 , 33 ] For example, carriers of DAO C2029G mutated allele tend to develop more severe symptoms of rhinitis and other histamine intolerance-related symptoms [ 17 , 18 , 34 ]. Therefore, in future studies this fact must be corroborated.…”

Section: Discussionmentioning

confidence: 99%

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

Mayo‐Yáñez¹,

Díaz-Díaz²,

Vázquez-Barro³

et al. 2021

ALS

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Aim: To analyze the diamine oxidase (DAO), the main catabolic enzyme of histamine, degradation activity and its relation with symptoms of persistent allergic rhinitis. Methods: In this descriptive and analytical observational study, we collected DAO activity levels and the nasal peak inspiratory flow. Results: Enzymatic activity deficit in 108 patients was 46.3% (95% CI, 0.44 – 0.63), 33.33% in mild and 47.92% in moderate/severe rhinitis (p = 0.376). The nasal peak inspiratory flow in patients with a deficit in DAO activity was 76.30 ± 28.40 L/min compared to 93.62 ± 37.50 L/min in patients with normal enzymatic activity (p = 0.010). Conclusions: It seems that the lower the catabolic activity of DAO, the lower the nasal peak inspiratory flow observed. Although DAO activity levels could be a severity biomarker in allergic rhinitis, a cause-effect association cannot be concluded. The enzyme could be another actor in the pathophysiology of allergic rhinitis.

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Asociación de polimorfismos de diaminoxidasa e histamina N metiltransferasa con la presencia, discapacidad y severidad de migraña en un grupo de madres mexicanas de niños alérgicos

Abstract: We suggest a synergistic association between HNMT and DAO functional polymorphisms and migraine; this hypothesis must be further confirmed by larger studies. However, the characteristics and ethnic differences between analysed populations should be considered when interpreting the results.

Cited by 15 publications

References 38 publications

Low serum diamine oxidase (DAO) activity levels in patients with migraine

Low serum diamine oxidase (DAO) activity levels in patients with migraine

Biogenic Amines in Plant-Origin Foods: Are they Frequently Underestimated in Low-Histamine Diets?

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report

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