Askin’s tumor: a case report and literature review

Benbrahim, Zineb; Arifi, Samia; Daoudi, Khalid; Serraj, M.; Amara, B.; Benjellοun, Mohammed; Mellas, Nawfel; Mesbahi, Omar El

doi:10.1186/1477-7819-11-10

Cited by 20 publications

(27 citation statements)

References 13 publications

(14 reference statements)

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“…Interestingly, this tumor localization, along with local rib and lung invasion observed in our model, is a characteristic of Askin tumors - a specific subgroup of primitive neuroectodermal tumors (PNET) [45, 46]. This thoracopulmonary localization of SK-ES1 metastases implicates specific biological features of tumor cells, which facilitate their growth in this particular region [45, 46]. Another characteristic feature of SK-ES1 tumors is their affinity for neural tissues, as manifested by the presence of brain and spine metastases.…”

Section: Discussionmentioning

confidence: 98%

“…Although rare, brain metastases are associated with a particularly poor outcome in ES patients and factors facilitating their formation remain unknown [3]. Given the unfavorable prognosis of Askin tumors (14% 6-year survival) and ES patients with secondary cerebral tumors, uncovering the mechanisms underlying such properties of ES subsets via our model may inform novel therapeutic approaches [45, 46]. …”

Section: Discussionmentioning

confidence: 99%

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High neuropeptide Y release associates with Ewing sarcoma bone dissemination -in vivomodel of site-specific metastases

et al. 2015

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Ewing sarcoma (ES) develops in bones or soft tissues of children and adolescents. The presence of bone metastases is one of the most adverse prognostic factors, yet the mechanisms governing their formation remain unclear. As a transcriptional target of EWS-FLI1, the fusion protein driving ES transformation, neuropeptide Y (NPY) is highly expressed and released from ES tumors. Hypoxia up-regulates NPY and activates its pro-metastatic functions. To test the impact of NPY on ES metastatic pattern, ES cell lines, SK-ES1 and TC71, with high and low peptide release, respectively, were used in an orthotopic xenograft model. ES cells were injected into gastrocnemius muscles of SCID/beige mice, the primary tumors excised, and mice monitored for the presence of metastases. SK-ES1 xenografts resulted in thoracic extra-osseous metastases (67%) and dissemination to bone (50%) and brain (25%), while TC71 tumors metastasized to the lungs (70%). Bone dissemination in SK-ES1 xenografts associated with increased NPY expression in bone metastases and its accumulation in bone invasion areas. The genetic silencing of NPY in SK-ES1 cells reduced bone degradation. Our study supports the role for NPY in ES bone invasion and provides new models for identifying pathways driving ES metastases to specific niches and testing anti-metastatic therapeutics.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

High neuropeptide Y release associates with Ewing sarcoma bone dissemination -in vivomodel of site-specific metastases

et al. 2015

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“…According to classification of tumors of the nervous system, Askin's tumor is a member of the Ewing's sarcoma family of tumors/peripheral PNETs. The clinical occurrence of Askin's tumor is rare and only a limited number of cases have been documented (6)(7)(8)(9)(10)(11). The present study reported 11 cases of Askin's tumor, a relatively large sample size in terms of its incidence rate.…”

Section: Discussionmentioning

confidence: 79%

Askin's tumor: 11 cases and a review of the literature

Zhang

Lu²,

Zhang³

et al. 2015

Oncology Letters

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Abstract. Askin's tumor is a peripheral primitive neruoectodermal tumor within the thoracopulmonary region, which primarily occurs in children and young adults. In addition, Askin's tumor is commonly misdiagnosed, as it is rare and easily mistaken for other small round-cell tumors. The present study aimed to investigate the clinical characteristics, prognostic factors and treatment outcomes of patients diagnosed with Askin's tumor. Computed tomography (CT) scans, histopathology and immunohistochemical analysis were used for diagnosis. Patients were treated with combined (surgery-chemotherapy-radiotherapy) or mono-therapy (chemotherapy or radiotherapy) methods. A total of 11 consecutive patients with Askin's tumor (aged 8-22 years) were treated at the First Affiliated Hospital of Zhengzhou University between April 2010 and June 2013; nine patients underwent combined therapy and two patients were treated using mono-therapy. Chest lumps, swelling and pain were the most common presenting symptoms. Patients were followed up for ≤24 months post surgery and the results revealed that the median survival time of the combined and mono-therapy treatment groups were 15 and 7 months, respectively. Primary tumor size, metastasis, lactate dehydrogenase indicators and tumor stages were found to be important prognostic factors affecting patient outcome. In conclusion, the results of the present study demonstrated that the combination of surgery, chemotherapy and radiotherapy resulted in the optimal outcome for Askin's tumor patients.

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“…Si existe alteraciones en el descenso tiroideo, se puede encontrar tejido glandular aberrante a lo largo del trayecto del conducto tirogloso. La ectopia tiroidea es un tipo de disgenesia con una prevalencia de 1:7.000, siendo más común en mujeres que en hombres con una relación 4:1 [3,4]. Se describen ectopias linguales, sublinguales, tiroglósicas e intralaringotraqueales, siendo las primeras las más frecuentes [5].…”

Section: Introductionunclassified

“…Se precisa realizar diagnóstico diferencial con hemangiomas, linfomas, fibromas, abscesos y tumores malignos de la lengua [7]. Casos de tiroides ectópica lingual son diagnosticados de forma incidental con métodos de imagen [3,6].…”

Section: Introductionunclassified

Tiroides Lingual Ectópica en Paciente Adulta Hipotiroidea. Diagnóstico Casual por Tomografía Computarizada

Sánchez

Martinod

García³

et al. 2019

Rev. Oncol. Ecu.

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ResumenIntroducción: Los casos de tiroides ectópica localizados en la base de la lengua son anormalidades congénitas raras y difíciles de diagnosticar. Razón de presentación del caso.Caso Clínico: El caso corresponde a una mujer de 41 años con tiroides en base de la lengua diagnosticada incidentalmente con tomografía computarizada (TC), con antecedentes de hipotiroidismo y cáncer de mama derecha. Al examen físico de cuello no se palpa glándula tiroidea ni se observa masa o protuberancia en cavidad bucal. Por control del cáncer de mama, se solicita tomografía por emisión de positrones (PET) y ecografía de cuello, reportándose captación del radiofármaco en la región cervical anterior y superior de cuello, y ausencia de tejido glandular tiroideo a nivel habitual, respectivamente. Por cuanto, se realiza TC simple y contrastada observándose a nivel de la raíz de la lengua una imagen nodular hipercaptante que mide 23x20x20 mm, bien definida, contornos regulares, no infiltra tejidos adyacentes, impronta luz de la orofaringe, sin individualizar la glándula tiroides a nivel habitual, corroborando así el diagnóstico de tiroides ectópica lingual.Conclusión: El diagnóstico de tiroides ectópica en paciente adulto hipotiroideo es raro, por lo que debe considerarse la realización de TC si al examen físico y ecográfico no es palpable ni observable.Palabras Claves: DISGENESIAS TIROIDEAS, TIROIDES LINGUAL, TOMOGRAFÍA COMPUTARIZADA POR RAYOS X, ECUADOR. Copyright Tufiño, et al. Este artículo es distribuido bajo los términos de Creative Commons Attribution License 4.0 , el cual permite el uso y redistribución citando la fuente y al autor original. AbstractIntroduction: Cases of ectopic thyroid located at the base of the tongue are rare and difficult to diagnose congenital abnormalities. Reason for presenting the case.Clinical case: The case corresponds to a 41-year-old woman with thyroid based on the tongue diagnosed incidentally with computed tomography (CT), with a history of hypothyroidism and right breast cancer. On the physical examination of the neck, the thyroid gland is not palpated, and no mass or bump is observed in the oral cavity. For breast cancer control, positron emission tomography (PET) and neck ultrasound are requested, radiopharmaceutical uptake is reported in the anterior and upper cervical neck region, and absence of thyroid glandular tissue at the usual level, respectively. As a simple and contrasted CT scan, a hypercapting nodular image measuring 23x20x20 mm, well defined, regular contours is observed at the root of the tongue, does not infiltrate adjacent tissues, oropharynx light imprint, without individualizing the thyroid gland to usual level, thus corroborating the diagnosis of lingual ectopic thyroid.Conclusion: The diagnosis of ectopic thyroid in an adult hypothyroid patient is rare, so CT should be considered if the physical and ultrasound examination is not palpable or observable.

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Askin’s tumor: a case report and literature review

Cited by 20 publications

References 13 publications

High neuropeptide Y release associates with Ewing sarcoma bone dissemination -in vivomodel of site-specific metastases

High neuropeptide Y release associates with Ewing sarcoma bone dissemination -in vivomodel of site-specific metastases

Askin's tumor: 11 cases and a review of the literature

Tiroides Lingual Ectópica en Paciente Adulta Hipotiroidea. Diagnóstico Casual por Tomografía Computarizada

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