Asian Study of Cerebral Venous Thrombosis

Wasay, Mohammad; Kaul, Subash; Menon, Bindu; Dai, Alper; Saadatnia, Mohammad; Malik, Abdul; Khalifa, Ayman M.; Borhani‐Haghighi, Afshin; Mehndiratta, Manmohan; Khan, Maria; Bhowmik, Nimalendu Bikash; Awan, Safia

doi:10.1016/j.jstrokecerebrovasdis.2019.06.005

Cited by 55 publications

(79 citation statements)

References 26 publications

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“…Less effective causes of CVT are trauma, drugs, infection mainly in parameningeal locations, dehydration, systemic diseases (e.g., nephrotic syndrome), Polyarteritis nodosa, systemic lupus erythematosus, inflammatory bowel disease, and JV&C hematologic diseases (e.g., iron deficiency anemia and paroxysmal nocturnal hemoglobinuria) (20)(21)(22)(23). A higher incidence of CVT in Iran might be attributed to the higher frequency of oral contraceptive consumption, especially in Ramadan (i.e., a religious month).…”

Section: Resultsmentioning

confidence: 99%

“…The CVT is a rare and important cause of stroke accounting for less than 5% of all strokes mainly affecting young females (6). Most of the symptoms are associated with the involved intravenous structure, presence of a qualified collateral system, and increased intracranial pressure ranging from headache associated with papilledema to focal neurologic deficits, seizure, and coma (21)(22)(23)31). The diagnosis is typically based on clinical suspicion and confirmatory neuroimaging.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, the treatment is based on anticoagulant therapy in which an increasing trend has been toward NOACs. In addition, in severe and potential fetal cases, heroic treatments, such as decompressive surgery and endovascular thrombolysis, might contribute to better prognosis (21,64,(66)(67)(68)(69)(70)(71). The risk stratification scores predict the poor prognosis for the identification of high-risk patients (78,79,81).…”

Section: Resultsmentioning

confidence: 99%

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An Update on Diagnosis and Treatment of Cerebral Venous Thrombosis in Adults: A Narrative Review

Paybast

Aghamiri

2020

J Vessel Circ

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Background and Aim: Cerebral venous thrombosis (CVT) is a relatively common disorder of the cerebral venous system accounting for less than 1% of all strokes with a higher prevalence in Iran. Despite the considerable advances in recent years, the diagnosis and treatment of CVT are still challenging predominantly in the emergency setting. Therefore, the present study sought to provide an update on the diagnosis and treatment of CVT. Materials and Methods: PubMed, Web of Science, Google Scholar, Scopus, Elsevier, and Iranian domestic scientific databases were searched within January 1, 2000, to July 1, 2020. In all the electronic databases, the keywords (in the title/abstract) of "cerebral vein thrombosis" OR "CVT" OR "Cerebral venous sinus thrombosis" OR "CVST" AND "risk factor", "diagnosis", "treatment", and "prognosis" were searched. The unrelated articles, studies not concerning humans or pediatric population, and case reports were excluded from the study. In addition, the articles related to CVT in association with coronavirus disease 2019 infection were excluded from the present review. Results: According to the findings of the present study, the diagnosis of CVT might be delayed due to a wide range of clinical manifestations from a subacute headache with or without the signs of intracranial hypertension to the acute focal neurologic deficit and even loss of consciousness. Although the diagnosis is typically based on brain magnetic resonance imaging and magnetic resonance venography, there has been evidence suggesting that the plain computed tomography markers with an attenuation value of > 60.4 Hounsfield unit (HU) and Hounsfield-hematocrit (H: H) ratio of > 1.42 are specific enough for the diagnosis regardless of confirmatory imaging, such as venography. Additionally, the usefulness of D-dimer is still debatable, and an unacceptable false-negative rate of up to 26% has been illustrated. In terms of therapeutic aspects, although warfarin is still the mainstay of treatment, there has been increasing interest in new oral anticoagulants with promising results in both thrombus recanalization and excellent functional recovery. Balloon angioplasty and mechanical thrombectomy might also be considered in severely progressive cases without response to conventional treatments. It is worth mentioning that even for those achieving favorable outcomes, CVT can remain a disabling condition leading to at least neuropsychiatric complaints. Conclusion: The CVT is a rare and important cause of stroke accounting for less than 5% of all strokes mainly affecting young females. With regard to the rarity of the disease and novelty of the therapeutic approaches, there is a long way to fully identify the best diagnostic and therapeutic approaches to the disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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An Update on Diagnosis and Treatment of Cerebral Venous Thrombosis in Adults: A Narrative Review

Paybast

Aghamiri

2020

J Vessel Circ

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“…Cerebral venous sinus thrombosis (CVST) is far less common than arterial stroke [1]; however, it occupies a prominent place in the field of cerebrovascular medicine due to the involvement of young adults and women of reproductive age [2,3]. Furthermore, acute-phase survival and favorable long-term prognosis depend strongly on receiving prompt and adequate treatment.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Venous Sinus Thrombosis Associated with COVID-19: A Case Series and Literature Review

Ostovan

Foroughi

Rostami

et al. 2020

Preprint

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Background: Since the COVID-19 pandemic, several cases of cerebral venous sinus thrombosis (CVST) have been reported in SARS-CoV-2 infected individuals. This study provides a series of patients with CVST and SARS-CoV-2 infection.Methods: Consecutive patients with documented SARS-CoV-2 infection, as well as clinical and radiological characteristics of CVST, were reported from three teaching hospitals in the South West, North West, and the center of Iran from June to July 2020. We also searched the abstract archives until the end of August 2020 and gathered 28 reported cases. The diagnostic criteria for SARS-CoV-2 infection were determined according to SARS-CoV-2 detection in oropharyngeal or nasopharyngeal samples in clinically suspected patients. Demographics, main COVID-19 symptoms, confirmatory tests for SARS-CoV-2 infection diagnosis, the interval between the diagnosis of SARS-CoV-2 infection and CVST, clinical and radiological features of CVST, therapeutic strategies, CVST outcomes, rate of hemorrhagic transformation, and mortality rate were investigated.Results: Six patients (aged 31 to 62 years old) with confirmed CVST and SARS-CoV-2 infection were admitted to our centers. Four patients had no respiratory symptoms of SARS-CoV-2 infection. Five out of six patients developed the clinical manifestations of CVST and SARS-CoV-2 infection simultaneously. Three patients had known predisposing factors for CVST. Despite receiving CVST and SARS-CoV-2 infection treatments, four out of six patients passed away.Conclusions: The role of SARS-CoV-2 as a “cause” versus an “additive contributor” remains to be elucidated. Practitioners should be aware of the possibility of CVST in SARS-CoV-2 infection.

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“…As a Potentially Life-Threatening Disease; Cerebral Venous Sinus Thrombosis 15 should refer any physician to CVST. Public and physician awareness can play a key role in early diagnosis and treatment of these patients[6].The results of a study investigating the relationship between clotting age and recanalization using Magnetic resonance blackblood thrombus imaging (MRBTI) in patients with severe CVST treated with endovascular treatment were promising. MRBTI has recently been proposed as a noninvasive imaging tool for direct thrombus imaging.…”

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confidence: 99%

As a Potentially Life-Threatening Disease; Cerebral Venous Sinus Thrombosis

Sönmezler¹

2019

Act Scie Neuro

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Cerebral venous sinus thrombosis(CVST) includes thrombosis of dural sinuses and/or veins. It constitutes less than 1% of all stroke and is usually seen in young people. More prevalence in young women is due to pregnancy, puerperium and oral contraceptive pills (OCP) use. CVST leads to infarction of the draining zone brain parenchyma. Patients usually present with headache, seizures, papilledema, altered consciousness, and focal neurological deficits. Headache is the most common patient presentation. The quality of this headache is highly variable with no specific location or pattern. The use of magnetic resonance imaging is more sensitive for diagnosis in all stages of thrombosis than the use of computed tomography. Digital subtraction angiography (DSA) is 10. Behrouzi R and Punter M. "Diagnosis and management of cerebral venous thrombosis".

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Asian Study of Cerebral Venous Thrombosis

Cited by 55 publications

References 26 publications

An Update on Diagnosis and Treatment of Cerebral Venous Thrombosis in Adults: A Narrative Review

An Update on Diagnosis and Treatment of Cerebral Venous Thrombosis in Adults: A Narrative Review

Cerebral Venous Sinus Thrombosis Associated with COVID-19: A Case Series and Literature Review

As a Potentially Life-Threatening Disease; Cerebral Venous Sinus Thrombosis

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