Asian Elm tree inner bark prevents articular cartilage deterioration in ovariectomized obese rats with monoiodoacetate-induced osteoarthritis

Abstract

UCE was an effective therapeutic agent for preventing osteoarthritis and KME prevented decreases in lean body mass, bone mineral density, and insulin sensitivity in estrogen-deficient rats.

Dangguijihwang-tang and Dangguijakyak-san Prevent Menopausal Symptoms and Dangguijihwang-tang Prevents Articular Cartilage Deterioration in Ovariectomized Obese Rats with Monoiodoacetate-Induced Osteoarthritis

“…After 12 h fasting, rats underwent bilateral OVX under anesthesia, induced by subcutaneous injection of a mixture of ketamine and xylazine (100 and 10 mg/kg body weight, resp. ), as described previously [ 29 , 30 ].…”

“…On the day following the MIA injections, the rats were observed for changes in behaviors and in right knee morphology by a single, trained technician. MIA injection is considered to induce osteoarthritis in joints by damaging glycolysis in the joint, resulting in the eventual death of chondrocytes by inhibiting glyceraldehyde-3-phosphate dehydrogenase activity and increasing inflammation [ 29 , 32 ].…”

“…The dosage of each herbal prescription was about 50 mg/kg bw for human. The extract powders were mixed with a high-fat diet since the diet exacerbated the progression of menopausal symptoms and osteoarthritis in comparison to a low-fat diet [ 29 , 33 ]. The high-fat diet was made with a semipurified modified AIN-93 formulation for experimental animals.…”

“…The animals were laid in a prone position with posterior legs and hip, knee, and ankle articulations being maintained in 90° flexion with external rotation with tape, after anesthetization with ketamine and xylazine (100 and 10 mg/kg bw, resp.). After scanning leg, hip, and knee areas on the right side, BMD was determined by the DEXA instrument equipped with the appropriate software for BMD assessment in small animals [ 29 ]. Fat mass and lean mass were also measured in a similar manner to BMD by DEXA.…”

Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

“…Particularly, it has long been used in regenerating stomach or skin epithelial cells. Korea elms are also known for their effects on blood circulation, the protection of cartilage degeneration, and damaged tissue regeneration [9]. With regard to topical use, elms have been administered for the treatment of minor skin irritations, cold sores, ulcers, abscesses, and boils [10].…”