Asian Consensus Report on Functional Dyspepsia

Abstract

Background/AimsEnvironmental factors such as food, lifestyle and prevalence of Helicobacter pylori infection are widely different in Asian countries compared to the West, and physiological functions and genetic factors of Asians may also be different from those of Westerners. Establishing an Asian consensus for functional dyspepsia is crucial in order to attract attention to such data from Asian countries, to articulate the experience and views of Asian experts, and to provide a relevant guide on management of functional dyspepsia for primary care physicians working in Asia.MethodsConsensus team members were selected from Asian experts and consensus development was carried out using a modified Delphi method. Consensus teams collected published papers on functional dyspepsia especially from Asia and developed candidate consensus statements based on the generated clinical questions. At the first face-to-face meeting, each statement was reviewed and e-mail voting was done twice. At the second face-to-face meeting, final voting on each statement was done using keypad voting system. A grade of evidence and a strength of recommendation were applied to each statement according to the method of the GRADE Working Group.ResultsTwenty-nine consensus statements were finalized, including 7 for definition and diagnosis, 5 for epidemiology, 9 for pathophysiology and 8 for management. Algorithms for diagnosis and management of functional dyspepsia were added.ConclusionsThis consensus developed by Asian experts shows distinctive features of functional dyspepsia in Asia and will provide a guide to the diagnosis and management of functional dyspepsia for Asian primary care physicians.

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

“…H. pylori is a microaerophilic gram negative spiral bacillus that infects the gastric mucosa in 20-80% of humans throughout the world and this bacteria was reported to be the major pathologic agent in the development of FD. Prevalence of H. pylori infection in FD patients varies from 30-80% (Vilaichone et al, 2011;Miwa et al, 2012). The study published in 2012 demonstrated that the DQB1*0401 genotype was related to a higher risk of H. pylori infection (Zhao et al, 2012).…”

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

“…A cumulative gain over time was shown, with a 25% reduction in medical visits due to dyspeptic complaints in patients who had eradicated the bacteria (89) . H pylori eradication in patients with functional dyspepsia is now a consensus recommendation established by leading experts in different regions of the world (132,141,192,207) .…”

Letter: East-West differences in the economic impact of functional dyspepsia

“…Having said that, the economic data reported in this study, and from other recent US-based studies, 2 may have little global relevance. FD is equally prevalent in the East, 3 but economic data remains sparse. A recent population-based study in South East Asia reported an estimated annual cost for uninvestigated dyspepsia of US $14 816.00 and US $59 282.20 per 1000 population in a rural and urban setting respectively.…”