ASHP Guidelines on Handling Hazardous Drugs

Partição de Comprimidos Antineoplásicos Utilizados no Tratamento de Leucemias Agudas em Crianças e Adolescentes

“…A partição dos comprimidos de mercaptopurina e tioguanina é preocupante, levando em consideração que são citotóxicos, considerados agentes perigosos, e que possuem margem de segurança relativamente estreita 11,12,17,27,28 . A contaminação pode ser por inalação, via oral e tópica 11,12,17,28 .…”

“…O local onde os antineoplásicos são partidos também foi um fator importante. Os resultados demonstraram que a maioria dos entrevistados partia na cozinha, o que é prejudicial, uma vez que os resíduos dos comprimidos partidos podem se misturar a alimentos e causar intoxicação às pessoas que os ingerirem 17,28 . Então, em áreas onde os quimioterápicos são administrados e manuseados, deve-se evitar comer, beber e manter alimentos 28 .…”

A Protocol for the Safe Use of Hazardous Drugs in the OR

“…According to NIOSH, exposure to HDs may result in health issues, such as skin rashes, infertility, spontaneous abortions, congenital malformations, and leukemia and other cancers . Repeated exposures may increase the chance of HCWs experiencing harmful effects if they do not protect themselves by adhering to occupational safety recommendations . As knowledge is gained regarding the potential dangers of HDs, the development of procedures to ensure a safe environment for HCWs has become more pressing.…”

“…The USP 〈800〉 requires that personnel handling HDs wear gloves that meet American Society of Testing and Materials standards . When administering injectable antineoplastic medications, personnel should wear protective gowns that have been tested for and demonstrated permeability resistance . However, the level of gown required is left to individual institutions to delineate in their specific policies.…”

“…9 Repeated exposures may increase the chance of HCWs experiencing harmful effects if they do not protect themselves by adhering to occupational safety recommendations. 16 As knowledge is gained regarding the potential dangers of HDs, the development of procedures to ensure a safe environment for HCWs has become more pressing. Employers are responsible for outlining HD handling procedures and instituting educational programs, but employees are responsible for their personal protection and should complete competencies and maintain strict adherence to standards.…”