Aseptic meningitis in association with glyphosate-surfactant herbicide poisoning

Sato, Chie; Kamijo, Yoshito; Yoshimura, Kuniko; Ide, Toshimitsu

doi:10.3109/15563650.2011.552065

Cited by 23 publications

(14 citation statements)

References 8 publications

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“…Some GBH components can cross the blood-brain barrier, as shown by acute poisoning cases with neurological alterations. For instance, a 58-year-old woman who attempted suicide by ingesting a large amount of a glyphosate-surfactant herbicide subsequently developed aseptic meningitis with measurable glyphosate concentrations in her cerebrospinal fluid (Sato et al 2011). A month after massive spraying of RoundUp V R without protection, a 70-year-old man developed a vasculitic neuropathy, which was allegedly linked to the herbicide (Kawagashira et al 2017).…”

Section: Neurologic Effectsmentioning

confidence: 99%

The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity

Peillex

Pelletier

2020

Journal of Immunotoxicology

174

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Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp V R , has continued to increase since 1974; glyphosate, as well as its primary metabolite aminomethylphosphonic acid, is measured in soils, water, plants, animals and food. In humans, glyphosate is detected in blood and urine, especially in exposed workers, and is excreted within a few days. It has long been regarded as harmless in animals, but growing literature has reported health risks associated with glyphosate and glyphosate-based herbicides. In 2017, the International Agency for Research on Cancer (IARC) classified glyphosate as "probably carcinogenic" in humans. However, other national agencies did not tighten their glyphosate restrictions and even prolonged authorizations of its use. There are also discrepancies between countries' authorized levels, demonstrating an absence of a clear consensus on glyphosate to date. This review details the effects of glyphosate and glyphosate-based herbicides on fish and mammal health, focusing on the immune system. Increasing evidence shows that glyphosate and glyphosate-based herbicides exhibit cytotoxic and genotoxic effects, increase oxidative stress, disrupt the estrogen pathway, impair some cerebral functions, and allegedly correlate with some cancers. Glyphosate effects on the immune system appear to alter the complement cascade, phagocytic function, and lymphocyte responses, and increase the production of pro-inflammatory cytokines in fish. In mammals, including humans, glyphosate mainly has cytotoxic and genotoxic effects, causes inflammation, and affects lymphocyte functions and the interactions between microorganisms and the immune system. Importantly, even as many outcomes are still being debated, evidence points to a need for more studies to better decipher the risks from glyphosate and better regulation of its global utilization.

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Section: Neurologic Effectsmentioning

confidence: 99%

The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity

Peillex

Pelletier

2020

Journal of Immunotoxicology

174

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“…In addition, data derived from structural MRI studies highlighted in a subject exposed to Gly changes in the T2 signal in substantia nigra, periaqueductal gray and globus pallidus, revealing likely lesions in these structures (Barbosa et al, 2001 ). Moreover, in human studies, Gly has been detected in the brain and cerebro-spinal fluid following commercial mixtures exposure, attesting that the active component can traverse the blood brain barrier (Menkes et al, 1991 ; Sato et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Behavioral and Immunohistochemical Study of the Effects of Subchronic and Chronic Exposure to Glyphosate in Mice

Ait-Bali

Ba‐M’hamed

Bennis

2017

Front. Behav. Neurosci.

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Many epidemiological studies have described an adolescent-related psychiatric illness and sensorimotor deficits after Glyphosate based herbicide (GBH) exposure. GBH exposure in animal models of various ages suggests that it may be neurotoxic and could impact brain development and subsequently, behavior in adulthood. However, its neurotoxic effects on adolescent brain remain unclear and the results are limited. The present study was conducted to evaluate the neurobehavioral effects of GBH following acute, subchronic (6 weeks) and chronic (12 weeks) exposure (250 or 500 mg/kg/day) in mice treated from juvenile age until adulthood. Mice were subjected to behavioral testing with the open field (OF), the elevated plus maze, the tail suspension and Splash tests (STs). Their behaviors related to exploratory activity, anxiety and depression-like were recorded. After completion of the behavioral testing, adult mice were sacrificed and the expression of tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNc) and serotonin (5-HT) in the dorsal raphe nucleus (DRN), the basolateral amygdala (BLA) and the ventral medial prefrontal cortex (mPFC) was evaluated using immunohistochemical procedure. Our results indicate that unlike acute exposure, both subchronic and chronic exposure to GBH induced a decrease in body weight gain and locomotor activity, and an increase of anxiety and depression-like behavior levels. In addition, the immunohistochemical findings showed that only the chronic treatment induced a reduction of TH-immunoreactivity. However, both subchronic and chronic exposure produced a reduction of 5-HT-immunoreactivity in the DRN, BLA and ventral mPFC. Taken together, our data suggest that exposure to GBH from juvenile age through adulthood in mice leads to neurobehavioral changes that stem from the impairment of neuronal developmental processes.

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“…Mixtures of chemicals such as Agent Orange or dioxins have also been cited as ENDs. In addition, formulants of pesticides—such as POEA (polyoxyethylene tallow amine)—have been discovered to be EDs more recently [Gasnier et al [ 19 ]; Defarge et al [ 20 ]] and may also possess nervous effects [Malhotra et al [ 21 ]; Sato et al [ 22 ]]. In some models, glyphosate alone [Martinez et al [ 23 ]; Coullery et al [ 24 ]], known as the declared active ingredient of a major pesticide formulation used across the world, has been shown to be less toxic or disruptive to the nervous system than its equivalent formulants present in Roundup [Mesnage et al [ 8 ]; Aitbali et al [ 25 ]; Gallegos et al [ 26 ]].…”

Section: Resultsmentioning

confidence: 99%

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Séralini

Jungers

2021

Toxicology Reports

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Aseptic meningitis in association with glyphosate-surfactant herbicide poisoning

Abstract: CNS signs and symptoms induced by aseptic meningitis should be considered in cases of glyphosate-surfactant herbicide poisoning.

Cited by 23 publications

References 8 publications

The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity

The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity

Behavioral and Immunohistochemical Study of the Effects of Subchronic and Chronic Exposure to Glyphosate in Mice

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

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