Aseptic Loosening after total hip arthroplasty secondary to the disappearing coating?

Tang, Kaiying; Deng, Zhibo; Wang, Ting; Nie, Mao

doi:10.1016/j.asjsur.2021.09.041

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…AL represents a significant challenge in the field of orthopedics following total joint arthroplasty [ 31 , 32 ]. This condition has been identified as a leading cause of failure for implanted prosthetics, prompting the need for repeated surgical interventions.…”

Section: Discussionmentioning

confidence: 99%

Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-κB signaling pathway

Wang,

Tao,

Chu

et al. 2023

Regenerative Biomaterials

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Aseptic loosening (AL) is considered a significant cause of prosthesis revision after arthroplasty and a crucial factor in the longevity of an artificial joint prosthesis. The development of AL is primarily attributed to a series of biological reactions, such as peri-prosthetic osteolysis (PPO) induced by wear particles around the prosthesis. Chronic inflammation of the periprosthetic border tissue and hyperactivation of osteoclasts are key factors in this process, which are induced by metallic wear particles like titanium particles (TiPs). In our in vitro study, we observed that TiPs significantly enhanced the expression of inflammation-related genes, including COX-2, IL-1β and IL-6. Through screening a traditional Chinese medicine database, we identified byakangelicol, a traditional Chinese medicine molecule that targets COX-2. Our results demonstrated that byakangelicol effectively inhibited TiPs-stimulated osteoclast activation. Mechanistically, we found that byakangelicol suppressed the expression of COX-2 and related pro-inflammatory factors by modulating macrophage polarization status and NF-κB signaling pathway. The in vivo results also demonstrated that byakangelicol effectively inhibited the expression of inflammation-related factors, thereby significantly alleviating TiPs-induced cranial osteolysis. These findings suggested that byakangelicol could potentially be a promising therapeutic approach for preventing PPO.

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Section: Discussionmentioning

confidence: 99%

Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-κB signaling pathway

Wang,

Tao,

Chu

et al. 2023

Regenerative Biomaterials

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“…Given their biocompatibility, appropriate mechanical properties, and corrosion resistance, titanium and its alloys are commonly used [29,30]. Implant ossification has been extensively investigated; however, the rate of aseptic loosening and related complications (stress-shielding, persistent pain, inflammation) is still a concern [31,32]. Research on surface treatment is ongoing to improve osseointegration and soft tissue adhesion [33][34][35][36][37]; however, no consensus has been reached, and titanium alloys are preferred.…”

Section: Discussionmentioning

confidence: 99%

Functionalised High-Performance Oxide Ceramics with Bone Morphogenic Protein 2 (BMP-2) Induced Ossification: An In Vivo Study

Migliorini

Eschweiler

Maffulli

et al. 2022

Life

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This study investigated the in vivo osseointegration potential of high-performance oxide ceramics (HPOCs) with peptide bone morphogenic protein 2 (BMP-2), comparing them with titanium implants. Histomorphometry was conducted around the distal, proximal, medial, and lateral sides of the implants to quantify the amount of mature and immature ossification within the bone interface. We hypothesised that HPOCs functionalised with BMP-2 promote ossification. HPOCs functionalised with BMP-2 were manufactured at the Department of Dental Materials Science and Biomaterial Research of the RWTH University Aachen, Germany. Histomorphometry was conducted by a professional pathologist in all samples. The region of interest (ROI) represented the percentage of the surrounding area of the implant. The percentages of ROI covered by osteoid implant contact (OIC) and mature bone–implant contact (BIC) were assessed. The surrounding presence of bone resorption, necrosis, and/or inflammation was quantitatively investigated. A total of 36 rabbits were used for the experiments. No bone resorption, necrosis, or inflammation was found in any sample. At the 12-week follow-up, the overall BIC was significantly increased (p < 0.0001). No improvement was evidenced in OIC (p = 0.6). At the 6-week follow-up, the overall OIC was greater in the BMP-2 compared to the titanium group (p = 0.002). The other endpoints of interest evidenced similarity between the two implants at various follow-up time points (p > 0.05). In conclusion, alumina HPOCs functionalised with peptide BMP-2 promote in vivo ossification in a similar fashion to titanium implants.

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“…Osteointegration is the capability of the implant to fuse with the surrounding bone, interacting and integrating with it [ 3 , 4 ] . The rate of aseptic loosening and related consequences (stress-shielding, persistent pain, inflammation) are still a concern in musculoskeletal medicine following implantation of foreign materials [ 5 , 6 ]. Given their optimal ossification, titanium and its alloys are commonly used [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Silica coated high performance oxide ceramics promote greater ossification than titanium implants: an in vivo study

et al. 2023

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Background This in vitro study investigated the osseointegration and implant integration of high performance oxide ceramics (HPOC) compared to titanium implants in rabbits. Methods Histomorphometry was conducted around the distal, proximal, medial, and lateral aspects of the HPOC to quantify the amount of mature and immature ossification within the bone interface. Histomorphometry was conducted by a trained musculoskeletal pathologist. The region of interest (ROI) represented the percentage of surrounding area of the implant. The percentage of ROI covered by osteoid implant contact (OIC) and mature bone implant contact (BIC) were assessed. The surrounding presence of bone resorption, necrosis, and/or inflammation were quantitatively investigated. Results All 34 rabbits survived the 6- and 12-week experimental period. All HPOC implants remained in situ. The mean weight difference from baseline was + 647.7 mg (P < 0.0001). The overall OIC of the ceramic group was greater at 6 weeks compared to the titanium implants (P = 0.003). The other endpoints of interest were similar between the two implants at all follow-up points. No difference was found in BIC at 6- and 12-weeks follow-up. No bone necrosis, resorption, or inflammation were observed. Conclusion HPOC implants demonstrated a greater osteoid implant contact at 6 weeks compared to the titanium implants, with no difference found at 12 weeks. The percentage of bone implant contact of HPOC implants was similar to that promoted by titanium implants.

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Aseptic Loosening after total hip arthroplasty secondary to the disappearing coating?

Cited by 3 publications

References 2 publications

Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-κB signaling pathway

Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-κB signaling pathway

Functionalised High-Performance Oxide Ceramics with Bone Morphogenic Protein 2 (BMP-2) Induced Ossification: An In Vivo Study

Silica coated high performance oxide ceramics promote greater ossification than titanium implants: an in vivo study

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