Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-κB signaling pathway
Zhidong Wang,
Huaqiang Tao,
Miao Chu
et al.
Abstract:Aseptic loosening (AL) is considered a significant cause of prosthesis revision after arthroplasty and a crucial factor in the longevity of an artificial joint prosthesis. The development of AL is primarily attributed to a series of biological reactions, such as peri-prosthetic osteolysis (PPO) induced by wear particles around the prosthesis. Chronic inflammation of the periprosthetic border tissue and hyperactivation of osteoclasts are key factors in this process, which are induced by metallic wear particles … Show more
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